Article
Cardiac & Cardiovascular Systems
Vivian Haffner, Zahra Nourian, Erika M. Boerman, Michelle D. Lambert, Laurin M. Hanft, Maike Krenz, Christopher P. Baines, Dongsheng Duan, Kerry S. McDonald, Timothy L. Domeier
Summary: In this study, the effects of Duchenne muscular dystrophy (DMD) on cardiomyocyte Ca2+ handling were investigated using a mouse model. The results indicate that DMD leads to Ca2+ overload in cardiomyocytes following preload challenge, as well as impaired cardiac function. These findings support the hypothesis that cardiomyocyte Ca2+ overload underlies cardiac dysfunction in muscular dystrophy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Merlo, Marco Mase, Andrew Perry, Eluisa La Franca, Elena Deych, Laura Ajello, Diego Bellavia, Andrea Boscutti, Marco Gobbo, Giuseppe Romano, Davide Stolfo, John Gorcsan, Francesco Clemenza, Gianfranco Sinagra, Luigi Adamo
Summary: In patients with non-ischaemic dilated cardiomyopathy (NICM) and normalised left ventricular ejection fraction (LVEF), an impaired absolute global longitudinal strain (aGLS) at the time of LVEF recovery is common and associated with worse outcomes.
Article
Cardiac & Cardiovascular Systems
Thijs P. Kerstens, Wouter M. van Everdingen, Jesse Habets, Arie P. J. van Dijk, Willem A. Helbing, Dick H. J. Thijssen, Floris E. A. Udink ten Cate
Summary: In pediatric patients with Duchenne muscular dystrophy (DMD), lower global strain is associated with the presence and extent of left ventricular (LV) myocardial fibrosis, while segmental strain does not seem to correspond to the location of fibrosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Kakeru Ishihara, Yoshiaki Kubota, Junya Matsuda, Yoichi Imori, Yukichi Tokita, Kuniya Asai, Hitoshi Takano
Summary: This study aimed to identify the predictive factors for dilated phase (DHCM) progression in patients with hypertrophic cardiomyopathy (HCM), and to investigate the effects of percutaneous transluminal septal myocardial ablation (PTSMA) on DHCM development. The study included 291 HCM patients and found that baseline atrial fibrillation, nonsustained ventricular tachycardia, and left ventricular diameter at end-systole were significant predictors of DHCM. PTSMA did not have a significant effect on long-term left ventricular ejection fraction changes or DHCM development. However, further validation with a larger population is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Christien Noel Haddad, Shirin Ali, Demetra Stephanou, Maria Stordahl Assakura, Lilit Sahagian, Efstratios Trogkanis
Summary: Duchenne muscular dystrophy is a fatal genetic disease affecting 1 in every 3500 births. This systematic review investigated the pharmacotherapy of dilated cardiomyopathy in patients with Duchenne muscular dystrophy, finding promising effects of certain drugs on heart function and prognosis. Further research with larger populations and longer periods is needed.
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daria De Giorgio, Deborah Novelli, Francesca Motta, Marianna Cerrato, Davide Olivari, Annasimon Salama, Francesca Fumagalli, Roberto Latini, Lidia Staszewsky, Luca Crippa, Christian Steinkuhler, Simonetta Andrea Licandro
Summary: Duchenne muscular dystrophy (DMD) is a common hereditary disease characterized by muscle degeneration. This study focused on D2-mdx mice as a model for DMD cardiomyopathy. The researchers found mild to moderate left ventricle remodeling, increased pulmonary vascular resistance, and prominent epicardial fibrosis in the right ventricle of these mice. The study highlights the need for further long-term investigation to determine if this model accurately represents DMD cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Rasheed Durowoju, Song Li, Gary S. Huang
Summary: Takotsubo syndrome (TTS) is evaluated by monitoring left ventricular ejection fraction (LVEF), but there is limited data on the correlation between echocardiographic findings and long-term outcomes. This study assessed clinical outcomes in TTS patients and their association with echocardiographic parameters. The results showed no significant association between echocardiographic parameters and clinical end points, with a low readmission rate and a majority of patients experiencing normalization of LVEF.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Jamie R. Johnston, Daniel F. Selgrade, Elizabeth M. McNally
Summary: Mutations in the LMNA gene are a common cause of adult-onset cardiomyopathy and heart failure, with a prenatal feature of impaired cardiomyocyte development and maturation identified in a Laminopathy model. Treatment of the LMNA H222P mouse model improved congenital cardiomyopathy and increased survival in utero, presenting a unique therapeutic strategy for cardiomyopathy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Cedric Happi Mbakam, Joel Rousseau, Yaoyao Lu, Anne Bigot, Kamel Mamchaoui, Vincent Mouly, Jacques P. Tremblay
Summary: In this study, researchers used CRISPR-Cas9 prime editing technology to correct a mutation in the DMD gene, resulting in improved editing efficiency and restoration of dystrophin protein expression. Optimization of the reverse transcription template sequence led to a significant increase in the editing percentage of the target nucleotide.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Clinical Neurology
Russell J. Butterfield, Sergey Kirkov, Kristin M. Conway, Nicholas Johnson, Dennis Matthews, Han Phan, Bo Cai, Pangaja Paramsothy, Shiny Thomas, Marcia L. Feldkamp
Summary: This study found no association between corticosteroid use after LOA and the onset of abnormal LV function, but a significant association with a delay in the onset of abnormal ppFVC.
Article
Biochemistry & Molecular Biology
Zsofia Onodi, Petra Lujza Szabo, Daniel Kucsera, Peter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y. Oudit, Bruno K. Podesser, Peter Ferdinandy, Zoltan V. Varga, Attila Kiss
Summary: Duchenne muscular dystrophy (DMD) is a muscle wasting disease characterized by difficulty moving and premature death, mainly due to heart failure. Inflammation is thought to play a role in the disease progression, but the specific mechanisms are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Nidhi Prakash, Renu Suthar, Bhupendra Kumar Sihag, Uma Debi, Rohit Manoj Kumar, Naveen Sankhyan
Summary: This study compared cardiac MRI (CMRI) with transthoracic echocardiography (TTE) for the diagnosis of cardiomyopathy in early ambulatory boys with Duchenne muscular dystrophy (DMD). The results showed that CMRI detected a higher percentage of early features of DMD-related cardiomyopathy compared to echocardiography.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Federica Rossin, Elena Avitabile, Giorgia Catarinella, Ersilia Fornetti, Stefano Testa, Serafina Oliverio, Cesare Gargioli, Stefano Cannata, Lucia Latella, Federica Di Sano
Summary: Skeletal muscle is essential for human posture, movement, and breathing, with recent studies suggesting that changes in muscle metabolism and ER stress may contribute to various muscle disorders. RTN-1C, a protein involved in muscle metabolism, shows potential as a new target for promoting muscle regeneration and repair.
Article
Veterinary Sciences
Sarah M. Schneider, Garett T. Sansom, Lee-Jae Guo, Shinji Furuya, Brad R. Weeks, Joe N. Kornegay
Summary: This study systematically assessed cardiac lesions in carrier dogs, GRMD dogs, and normal dogs, and found that quantitative analysis of the cross-sectional area of fibrosis can distinguish the health status of different groups of dogs. The features identified in GRMD dogs are compatible with those of DMD, validating GRMD as an effective model for studying cardiomyopathy.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seraina A. Dual, Nyasha G. Maforo, Doff B. McElhinney, Ashley Prosper, Holden H. Wu, Shiraz Maskatia, Pierangelo Renella, Nancy Halnon, Daniel B. Ennis
Summary: This study compared RV-T1 in boys with DMD and healthy controls, finding that precontrast RV-T1 was significantly elevated in boys with DMD compared to controls, and negatively correlated with right ventricular ejection fraction.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, In-Soo Kim, Jong-Youn Kim, Eui-Young Choi, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Hyuck Moon Kwon, Han Eol Cho, Won Ah Choi, Seong-Woong Kang, Se-Joong Rim
Summary: This study investigated the long-term clinical outcomes and associated factors in patients with late-stage Duchenne muscular dystrophy (DMD).
Article
Engineering, Biomedical
Jungseop Shin, Eui-Young Choi, Hyuck Moon Kwon, Kyehan Rhee
Summary: This study estimated the viscoelastic parameters of blood vessels using ultrasound images and pressure waveforms, and found a correlation between viscous parameters and arterial plaques. This suggests that viscous parameters may serve as a new mechanical index for early detection of atherosclerosis.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Medicine, Research & Experimental
Eun Kyoung Kim, Hong-Mi Choi, Eui-Young Choi, Hye Sun Lee, Goeun Park, Dong Woo Han, Sang-Eun Lee, Chan Seok Park, Ji-won Hwang, Jae Hyuk Choi, Mi-Na Kim, Hyung-Kwan Kim, Dae-Hee Kim, Sung-Hee Shin, Il Suk Sohn, Mi-Seung Shin, Jin Oh Na, Iksung Cho, Sun Hwa Lee, Yong Hyun Park, Tae-Ho Park, Kye Hun Kim, Goo-Young Cho, Hae Ok Jung, Dae-Gyun Park, Ji Yeon Hong, Duk-Hyun Kang
Summary: This study aims to evaluate the additional benefit of preoperative echocardiography in predicting postoperative cardiovascular events in noncardiac surgery. It includes two different trial groups to reduce postoperative cardiovascular events in intermediate- to high-risk surgery patients through discovery and intervention of unexpected cardiac abnormalities before surgery.
Article
Cardiac & Cardiovascular Systems
Eui-Young Choi, Jin-Sun Park, Deulle Min, Soohyun Ahn, Jeong-Ah Ahn
Summary: A mobile self-management app program called Heart Failure-Smart Life was developed to support heart failure patients. The experimental study showed significant improvements in symptom and cardiac diastolic function in the experimental group after 3 months of using the app. This study provides evidence that smartphone apps can effectively guide and support heart failure patients in self-management.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Jae-Sun Uhm, Kyu-Yong Ko, Chi Young Shim, Je-Wook Park, Minkwan Kim, Sung A. Bae, In Hyun Jung, In-Soo Kim, Jong Youn Kim, Eui-Young Choi, Won Jeong Son, Yun Ho Roh, Hee Tae Yu, Tae-Hoon Kim, Geu-Ru Hong, Boyoung Joung, Hui-Nam Pak, Moon-Hyoung Lee
Summary: This study aimed to investigate the relationship between premature ventricular complexes (PVCs) and right ventricular (RV) dysfunction, and the impact of radiofrequency catheter ablation (RFCA) on RV function. The results showed that frequent PVCs are associated with RV dysfunction and successful RFCA can reverse RV dysfunction.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Minkwan Kim, Chan Joo Lee, Hye-Jin Kang, Nak-Hoon Son, SungA Bae, Jiwon Seo, Jaewon Oh, Se-Joong Rim, In Hyun Jung, Eui-Young Choi, Seok-Min Kang
Summary: This study aimed to evaluate the impact of red cell distribution width (RDW) on the prognosis of patients with heart failure. The results showed that elevated RDW at the time of diagnosis was associated with poor prognosis in patients with heart failure, independent of clinical risk factors and echocardiographic parameters. RDW may have important implications in the management of patients with heart failure.
Article
Cardiac & Cardiovascular Systems
Eun Kyoung Kim, Hong-Mi Choi, Jong-Hwan Lee, Dong Woo Han, Hye Sun Lee, Eui-Young Choi
Summary: Preoperative echocardiography can predict the risk of postoperative adverse cardiovascular events in low-risk non-cardiac surgery patients, which is of great significance in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yumin Kim, Andrew D. Choi, Anha Telluri, Isabella Lipkin, Andrew J. Bradley, Alfateh Sidahmed, Rebecca Jonas, Daniele Andreini, Ravi Bathina, Andrea Baggiano, Rodrigo Cerci, Eui-Young Choi, Jung-Hyun Choi, So-Yeon Choi, Namsik Chung, Jason Cole, Joon-Hyung Doh, Sang-Jin Ha, Ae-Young Her, Cezary Kepka, Jang-Young Kim, Jin Won Kim, Sang-Wook Kim, Woong Kim, Gianluca Pontone, Todd C. Villines, Iksung Cho, Ibrahim Danad, Ran Heo, Sang-Eun Lee, Ji Hyun Lee, Hyung-Bok Park, Ji-min Sung, Tami Crabtree, James P. Earls, James K. Min, Hyuk-Jae Chang
Summary: We compared the diagnostic performance, costs, and association with major adverse cardiovascular events (MACE) of clinical coronary computed tomography angiography (CCTA) interpretation and a semiautomated artificial intelligence and machine learning approach (AI-QCT) for atherosclerosis imaging. The use of AI-QCT significantly reduced the rates and costs of invasive coronary angiography (ICA) in stable patients referred for nonemergent ICA, with no change in 1-year MACE.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hyemoon Chung, Jiwon Seo, In Soo Kim, Jong-Youn Kim, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum -Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Summary: Arterial stiffness index, exercise hemodynamic parameters, and echocardiographic left ventricular functional parameters are related to exercise-induced ST depression. Older age, higher pulmonary arterial systolic pressure, left atrial volume index, baPWV, ankle brachial index at rest, hypertensive response, higher heart rate, and rate-pressure product at peak exercise are significantly associated with ST depression. Higher peak heart rate, PASP, and baPWV are independently related to ST depression.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Hyemoon Chung, Eui-Young Choi
Summary: This article reviews the role of multimodal imaging in patients with hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), emphasizing the importance of evaluating the morphology and physiology of the atrium and ventricle for treatment and prognosis determination.