Article
Cardiac & Cardiovascular Systems
Fred S. Apple, Stephen W. Smith, Jaimi H. Greenslade, Yader Sandoval, William Parsonage, Isuru Ranasinghe, Niranjan Gaikwad, Karen Schulz, Laura Stephensen, Christian W. Schmidt, Brynn Okeson, Louise Cullen
Summary: By using a rapid point-of-care whole-blood hs-cTnI assay, it is possible to safely exclude the possibility of myocardial infarction and expedite discharge from the emergency department.
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Bradley R. Lewis, Ramila A. Mehta, Olatunde Ola, Jonathan D. Knott, Laura De Michieli, Ashok Akula, Ronstan Lobo, Eric H. Yang, S. Michael Gharacholou, Marshall Dworak, Erika Crockford, Nicholas Rastas, Eric Grube, Swetha Karturi, Scott Wohlrab, David O. Hodge, Tahir Tak, Charles Cagin, Rajiv Gulati, Allan S. Jaffe
Summary: Using a single hs-cTnT below the limit of quantitation of 6 ng/L is a safe and rapid method to identify a substantial number of patients at very low risk for acute myocardial injury and infarction.
Article
Cardiac & Cardiovascular Systems
Judit Cubedo, Teresa Padro, Gemma Vilahur, Filippo Crea, Robert F. Storey, Jose Luis Lopez Sendon, Juan Carlos Kaski, Alessandro Sionis, Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Alex Gallinat, Lina Badimon
Summary: The study found that myocardial ischemia leads to intracellular accumulation of non-glycosylated ApoJ and a reduction in ApoJ-Glyc secretion. Circulating levels of glycosylated apolipoprotein J significantly decrease early in AMI patients, serving as an indicator of ischemic events. Lower levels of ApoJ-Glyc at admission in ST-elevation myocardial infarction patients are associated with a higher rate of recurrent ischemic events and mortality.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Judit Cubedo, Teresa Padro, Gemma Vilahur, Filippo Crea, Robert F. Storey, Jose Luis Lopez Sendon, Juan Carlos Kaski, Alessandro Sionis, Jordi Sans-Rosello, Estefania Fernandez-Peregrina, Alex Gallinat, Lina Badimon
Summary: This study found that circulating levels of glycosylated apolipoprotein J decrease significantly in the early phase of acute myocardial infarction, and lower levels are associated with increased rates of recurrent ischemic events and mortality in AMI patients after 6 months.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Jingyue Wang, Botao Shen, Xiaoxing Feng, Zhiyu Zhang, Junqian Liu, Yushi Wang
Summary: Current prognostic models for cardiogenic shock lack external clinical verifications and there is an urgent need to establish a prognosis model with higher differentiation and coincidence rates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yader Sandoval, Fred S. Apple, Simon A. Mahler, Richard Body, Paul O. Collinson, Allan S. Jaffe
Summary: The guidelines for the evaluation and diagnosis of acute chest pain released by multiple associations in 2021 provide important recommendations, including the use of high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker, defining myocardial injury with 99th percentile upper reference limits, and utilizing clinical decision pathways. However, the guidelines do not extensively address the details of integrating hs-cTn into clinical practice, and clinicians need to be aware of analytical aspects related to hs-cTn assays and how to best use it with clinical decision pathways.
Article
Medicine, General & Internal
Olatunde Ola, Ashok Akula, Laura De Michieli, Jonathan D. Knott, Ronstan Lobo, Ramila A. Mehta, David O. Hodge, Rajiv Gulati, Yader Sandoval, Allan S. Jaffe
Summary: The study found limited value of HEAR scores in evaluating the short-term prognosis when assessing baseline hs-cTnT levels. Even in cases with low HEAR scores, patients with quantifiable hs-cTnT still had a higher risk of cardiovascular events within 30 days. HEAR scores overestimate risk when hs-cTnT remains within the reference range.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qi Liu, Rui-Juan Shi, Yi-Man Zhang, Yi-Heng Cheng, Bo-Sen Yang, Yi-Ke Zhang, Bao-Tao Huang, Mao Chen
Summary: AMI in young patients is associated with unhealthy lifestyles such as smoking, dyslipidemia, and obesity. Low LVEF, elevated NT-proBNP peak level, and the occurrence of in-hospital MACCEs were predictors of poor prognosis in premature AMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Bartosz Karolak, Michal Ciurzynski, Marta Skowronska, Katarzyna Kurnicka, Magdalena Plywaczewska, Aleksandra Furdyna, Katarzyna Perzanowska-Brzeszkiewicz, Barbara Lichodziejewska, Szymon Pacho, Michal Machowski, Piotr Bienias, Malgorzata Wisniewska, Marek Golebiowski, Piotr Pruszczyk
Summary: In the NOAC era, most low-risk acute pulmonary embolism (APE) patients can be treated at home, but identifying those at very low risk of clinical deterioration may be challenging. This study aimed to propose a risk stratification algorithm for sPESI 0 point APE patients, allowing them to select candidates for safe outpatient treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction has sparked debates aiming to define types of myocardial injury from a pathophysiological perspective, with necessary adjustments in clinical guidelines for real-world patient triage.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Thomas E. Kaier, Bashir Alaour, Michael Marber
Summary: The 4th Universal Definition of Myocardial Infarction aims to define types of myocardial injury based on their pathophysiology, sparking debates and leading to necessary pragmatic adjustments in clinical guidelines to improve triage of real-world patients.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sunil K. Vasireddi, Erica Pivato, Enrique Soltero-Mariscal, Raghuram Chava, Laurence O. James, Douglas Gunzler, Peter Leo, Meera D. Kondapaneni
Summary: The study found that current preoperative risk assessment tools cannot accurately predict the risk of postoperative troponin elevation and 1-year all-cause mortality. For low-risk MINS patients preoperatively, their 1-year mortality risk is significantly higher, with the majority of them not taking statins.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Uta Ceglarek, Paul Schellong, Maciej Rosolowski, Markus Scholz, Anja Willenberg, Juergen Kratzsch, Uwe Zeymer, Georg Fuernau, Suzanne De Waha-Thiele, Petra Buettner, Alexander Jobs, Anne Freund, Steffen Desch, Hans-Josef Feistritzer, Berend Isermann, Joachim Thiery, Janine Poess, Holger Thiele
Summary: This study developed a biomarker-based risk score for predicting 30-day mortality in patients with cardiogenic shock complicating acute myocardial infarction. The score was extensively validated and calibrated, showing superior prognostic performance compared to other clinical scores, suggesting it may be a useful tool for early decision-making in cardiogenic shock.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Uta Ceglarek, Paul Schellong, Maciej Rosolowski, Markus Scholz, Anja Willenberg, Juergen Kratzsch, Uwe Zeymer, Georg Fuernau, Suzanne de Waha-Thiele, Petra Buettner, Alexander Jobs, Anne Freund, Steffen Desch, Hans-Josef Feistritzer, Berend Isermann, Joachim Thiery, Janine Poess, Holger Thiele
Summary: This study developed a biomarker-based risk score for stratifying 30-day mortality risk in infarct-related CS. It was extensively validated and calibrated in a prospective cohort of contemporary patients with CS after AMI, outperforming other clinical scores and potentially serving as an early decision tool in CS.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Mitsuaki Sawano, Yuan Lu, Cesar Caraballo, Shiwani Mahajan, Rachel Dreyer, Judith H. Lichtman, Gail D'Onofrio, Erica Spatz, Rohan Khera, Oyere Onuma, Karthik Murugiah, John A. Spertus, Harlan M. Krumholz
Summary: Younger women have poorer health outcomes than men after experiencing acute myocardial infarction (AMI), and it is unknown whether they have a higher risk for cardiovascular and noncardiovascular hospitalizations in the year after discharge. This study aimed to determine sex differences in causes and timing of 1-year outcomes after AMI in people aged 18 to 55 years. Analysis of data showed that young women with AMI had a higher rate of hospitalization in the year after discharge, with a sex disparity in both coronary-related and noncardiac hospitalizations.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)