Editorial Material
Biochemistry & Molecular Biology
Panagiotis Anagnostis, Vasileios Kotsis, Maciej Banach, Dimitri P. P. Mikhailidis
Summary: Plant sterols, similar to cholesterol, can only be obtained through dietary sources and have the potential to lower cholesterol levels. However, high concentrations of phytosterols may increase the risk of atherosclerosis. Medications like ezetimibe can effectively reduce cholesterol and phytosterol absorption, but it is yet to be determined if this translates into a reduction in residual cardiovascular risk for patients.
Article
Cardiac & Cardiovascular Systems
Natalie C. Ward, Christopher M. Reid, Gerald F. Watts
Summary: This study found that nutraceuticals and ezetimibe independently or in combination can lower LDL-c in patients with hypercholesterolemia who are intolerant to statins.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Kenneth R. Feingold, Alan Chait
Summary: Elevated low-density lipoprotein cholesterol (LDL-C) levels increase the risk of atherosclerotic cardiovascular disease (ASCVD), and lowering LDL-C levels reduces this risk. The causes of elevated LDL-C levels can include lifestyle, medical conditions, medications, or genetic factors. This review outlines principles for treating patients with elevated LDL-C levels, including initiating therapy as early as possible, achieving a greater reduction in LDL-C levels, and considering the severity of LDL-C elevation and ASCVD risk.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Hematology
Mohammadreza Bordbar, Renee de Mutsert, Melike Cevval, Frits R. Rosendaal, J. Wouter Jukema, Willem M. Lijfering
Summary: This study compared the pro-thrombotic activities of different classes of lipid-lowering drugs and found that statin users had lower FXI levels compared to fibrate/niacin users, indicating the potential benefits of statins in the prevention of venous thromboembolism.
THROMBOSIS JOURNAL
(2021)
Review
Peripheral Vascular Disease
Klaus G. Parhofer
Summary: With the introduction of new injectable lipid-lowering drugs, the roles of traditional oral medications such as statins, ezetimibe, bile acid sequestrants, and fibrates need to be reevaluated, particularly for high-risk patients.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Review
Medicine, General & Internal
Reed Mszar, Sarah Bart, Alexander Sakers, Daniel Soffer, Dean G. Karalis
Summary: Hypertriglyceridemia (HTG) is a common medical condition in patients with cardiometabolic risk factors and can increase the risk of atherosclerotic cardiovascular disease (ASCVD) if ignored. Current guidelines recommend clinical evaluation and lifestyle-based interventions to address potential causes of elevated triglyceride (TG) levels. Statin therapy, alone or in combination with other lipid-lowering medications, is recommended for individuals with mild to moderate HTG at risk of ASCVD. Novel therapies targeting apoC-III and ANGPTL3 have shown promise in reducing TG levels. Public health strategies are needed to improve access to effective pharmacotherapies, affordable and nutritious food options, and timely healthcare services.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medical Laboratory Technology
Xin Su, Ye Cheng, Dong Chang
Summary: Dyslipidemia is associated with various health issues, and statins are highlighted as the cornerstone for lowering LDL-C. Other medications, like PCSK9 inhibitors, are being researched for their effectiveness in reducing circulating LDL-C. Guidelines emphasize individualized clinical precision medicine for dyslipidemia management, focusing on the importance of LDL-C reduction in preventing cardiovascular disease.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Magda Dubinska-Magiera, Marta Migocka-Patrzalek, Damian Lewandowski, Malgorzata Daczewska, Krzysztof Jagla
Summary: This article summarizes research on drug-induced myopathies using various models, and discusses the role and significance of zebrafish as a model in the study. The article also mentions the consideration of environmental issues arising from the global use of lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maciej Banach, Peter E. Penson, Michal Vrablik, Matjaz Bunc, Krzysztof Dyrbus, Jan Fedacko, Dan Gaita, Marek Gierlotka, Zoltan Jarai, Stefania Lucia Magda, Eduard Margetic, Roman Margoczy, Azra Durak-Nalbantic, Petr Ostadal, Daniel Pella, Matias Trbusic, Cristian Alexandru Udroiu, Charalambos Vlachopoulos, Dusko Vulic, Zlatko Fras, Dariusz Dudek, Zeljko Reiner
Summary: ASCVD and ACS contribute significantly to morbidity and mortality in Europe. Lowering LDL-C through lipid-lowering therapy is crucial for reducing cardiovascular risk, and starting treatment earlier is emphasized. Availability of additional effective therapies like ezetimibe and PCSK9 inhibitors can benefit high-risk patients.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Sonia Sawant, Nelson Wang
Summary: This study found that lipid-lowering therapy (LLT) has similar cardiovascular event reduction effects across different ethnicities and regions, highlighting the importance of promoting LLT in at-risk populations.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Health Care Sciences & Services
Nagham N. Hindi, Jamil Alenbawi, Georges Nemer
Summary: The rapid growth of genomic data and lack of appropriate clinical categorization of variants pose challenges to traditional medications. Global sequencing of healthy subjects and studying clustered familial diseases are tools to address this gap. Achieving an interactive genomic map related to drugs can benefit populations worldwide with dyslipidemia risk.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Kazuma Oyama, Robert P. Giugliano, Michael A. Blazing, Jeong-Gun Park, Andrew M. Tershakovec, Marc S. Sabatine, Christopher P. Cannon, Eugene Braunwald
Summary: The study found that adding ezetimibe to statin therapy consistently reduced the risk of cardiovascular events in post-ACS patients, regardless of baseline LDL-C values, supporting the use of intensive lipid-lowering therapy with ezetimibe even in patients with baseline LDL-C <70 mg/dL.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Geriatrics & Gerontology
Michael G. Nanna, Adam J. Nelson, Kevin Haynes, Sonali Shambhu, Zubin Eapen, Mark J. Cziraky, Sara B. Calvert, Neha J. Pagidipati, Christopher B. Granger
Summary: This study investigates the use of lipid-lowering therapies among older adults (>= 75 years old) with ASCVD in the United States. The findings indicate that less than half of eligible older adults with ASCVD are receiving statin therapy, and only a minority are receiving high-intensity lipid-lowering treatment. This highlights the need for improved promotion and implementation of lipid-lowering therapies in this population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Cardiac & Cardiovascular Systems
Hangying Ying, Jiacheng Wang, Zhida Shen, Meihui Wang, Binquan Zhou
Summary: The meta-analysis found that contemporary lipid-lowering medicines do not lead to cognitive impairment when lowering LDL-C levels. There was no significant difference in the incidence of cognitive disorder or global cognitive performance among patients receiving these medications.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Tiago Lourenco, Tania Vieira Madureira, Maria Joao Rocha, Eduardo Rocha
Summary: Fibrates and statins are widely prescribed lipid-lowering drugs, and their effects on fish, liver metabolism, and blood parameters are similar to those observed in humans. Establishing standardized fish models for studying hypolipidemic drugs has important current and future benefits.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Osman Najam, Bhuvana Krishnamoorthy, Isaac Kadir, Apostolos Paul Karagounis, Paul Waterworth, James E. Fildes, Nizar Yonan
ANNALS OF THORACIC SURGERY
(2011)
Article
Cardiac & Cardiovascular Systems
Bhuvaneswari Krishnamoorthy, Othman S. Al-Fagih, Mohammed I. Madi, Osman Najam, Paul D. Waterworth, James E. Fildes, Nizar Yonan
ANNALS OF THORACIC SURGERY
(2012)
Letter
Hematology
Ursalan A. Khan, Judith A. Davidson, Kay V. Poulton, Robert F. Wynn, James E. Fildes
BRITISH JOURNAL OF HAEMATOLOGY
(2011)
Review
Cardiac & Cardiovascular Systems
Christopher A. Miller, James E. Fildes, Simon G. Ray, Helen Doran, Nizar Yonan, Simon G. Williams, Matthias Schmitt
Review
Immunology
William R. Critchley, James E. Fildes
Article
Cardiac & Cardiovascular Systems
John P. Stone, Hannah Sevenoaks, Trygve Sjoberg, Stig Steen, Nizar Yonan, James E. Fildes
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2014)
Article
Endocrinology & Metabolism
Louise D. Archer, Kia J. Langford-Smith, William R. Critchley, Brian W. Bigger, James E. Fildes
JOURNAL OF INHERITED METABOLIC DISEASE
(2013)
Review
Endocrinology & Metabolism
Louise D. Archer, Kia J. Langford-Smith, Brian W. Bigger, James E. Fildes
JOURNAL OF INHERITED METABOLIC DISEASE
(2014)
Editorial Material
Neurosciences
Louise D. Archer, Kia Langford, Brian Bigger, James E. Fildes
JOURNAL OF NEUROSCIENCE RESEARCH
(2010)
Article
Immunology
Steven M. Shaw, William R. Critchley, Christopher M. Puchalka, Simon G. Williams, Nizar Yonan, James E. Fildes
TRANSPLANT IMMUNOLOGY
(2012)
Article
Immunology
William R. Critchley, Nizar Yonan, Steven M. Shaw, James E. Fildes
Article
Cardiac & Cardiovascular Systems
Bhuvaneswari Krishnamoorthy, William R. Critchley, Alex T. Glover, Janesh Nair, Mark T. Jones, Paul D. Waterworth, James E. Fildes, Nizar Yonan
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2012)
Article
Cardiac & Cardiovascular Systems
Syed Faisal Hashmi, Bhuvaneswari Krishnamoorthy, William R. Critchley, Peter Walker, Paul W. Bishop, Rajamiyer V. Venkateswaran, James E. Fildes, Nizar Yonan
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2015)
Article
Cardiac & Cardiovascular Systems
Bhuvaneswari Krishnamoorthy, William R. Critchley, Peter Bhinda, Jasmina Crockett, Anish John, Benjamin J. Bridgewater, Paul D. Waterworth, James Fildes, Nizar Yonan
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2015)
Article
Medical Laboratory Technology
Edward Hinchliffe, Joanne Adaway, James Fildes, Anna Rowan, Brian G. Keevil
ANNALS OF CLINICAL BIOCHEMISTRY
(2014)