LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE 2 : implications for targeting adenoma stem cells with NSAIDs

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Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

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Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells

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Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E 2 Signaling

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Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

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β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Isolation and in vitro expansion of human colonic stem cells

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

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Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward

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The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells

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HGF/Met signalling promotes PGE2 biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells

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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

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Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

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Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

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Crypt stem cells as the cells-of-origin of intestinal cancer

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Immunostaining of Lgr5, an Intestinal Stem Cell Marker, in Normal and Premalignant Human Gastrointestinal Tissue

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