Article
Oncology
Xiaopeng Zhao, Chuang Liu, Xu He, Miao Wang, Haoran Zhang, Jingge Cheng, Hongyan Wang
Summary: The study revealed the potential role of laminin in tumor progression, with high laminin expression associated with poor overall survival in NSCLC patients. Integrin alpha 6 beta 4 was identified as crucial for the pro-tumor effects of laminin, with downstream signaling involving the FAK/YAP/TAZ pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Wen-Kai Shi, Qiao-Li Shang, Yong-Fu Zhao
Summary: This study investigates the role of SPC25 in promoting hepatocellular carcinoma (HCC) progression. It is found that SPC25 is highly expressed in HCC and associated with poor prognosis and metastasis. Silencing SPC25 inhibits invasion and migration of HCC cells in vitro and in vivo. The study also reveals that SPC25 affects genes associated with extracellular matrix-integrin interactions, and upregulation of ITGB4 partially reverses the decline in cell invasion and migration capacities caused by SPC25 silencing. Blocking both SPC25 and ITGB4 reduces phosphorylation of downstream elements in the integrin pathway. Overall, this research highlights the important role of SPC25 as both a prognostic indicator and a promoter of metastasis in HCC.
Article
Immunology
Xiaohui Li, Jialu Liu, Mengru Zeng, Kexin Yang, Shumin Zhang, Yifei Liu, Xiangxiang Yin, Chanyue Zhao, Wenpeng Wang, Li Xiao
Summary: This study identified key genes related to macrophage-mediated inflammation in diabetic nephropathy through bioinformatics analysis and experimental validation. These genes, including CASP1, MS4A4A, CD53, and GBP2, may be involved in the progression of diabetic nephropathy. Among them, GBP2 may serve as a prognostic biomarker and intervention target for diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Qingxi Luo, Wenwen Shi, Bo Dou, Jun Wang, Wei Peng, Xianyu Liu, Deze Zhao, Faqing Tang, Yingfang Wu, Xizhe Li, Jiajia Li, Siqi Wen, Chunfang Zhang, Chaojun Duan
Summary: XBP1s protein is significantly overexpressed in NSCLC and promotes cell invasion and metastasis, making it a potential therapeutic target for NSCLC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhiqiang He, Yuhan Zhong, Haijie Hu, Fuyu Li
Summary: Gallbladder cancer (GBC) is a solid tumor with poor prognosis and current treatments are not effective. This study aimed to investigate a meaningful regulator in GBC. Zinc finger protein 64 (ZFP64) was identified as a vital regulatory protein in GBC. ZFP64 expression was higher in GBC tissues and correlated with poor prognosis. ZFP64 promoted migration, invasion, proliferation, anti-apoptosis, and epithelial mesenchymal transition (EMT) of GBC cells. Mechanistically, ZFP64 recruited HDAC1 to inhibit NUMB expression, leading to enhanced activation of the Notch1 signaling pathway. ZFP64 is expected to be a new focus for GBC prognostic marker and targeted therapy.
Article
Cell Biology
Jiewei Lin, Zhiwei Xu, Junjie Xie, Xiaxing Deng, Lingxi Jiang, Hao Chen, Chenghong Peng, Hongwei Li, Jiaqiang Zhang, Baiyong Shen
Summary: APOL1 is aberrantly expressed in pancreatic cancer and associated with poor prognosis. Functional experiments showed that APOL1 promotes proliferation and inhibits apoptosis in pancreatic cancer through activating NOTCH1 signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Grace Aprilia Helena, Teruhiko Watanabe, Yusuke Kato, Nobuaki Shiraki, Shoen Kume
Summary: By adjusting the thawing protocol and medium composition, we successfully improved the attachment of PHH cells on the collagen matrix. Removing BSA and exposing the cells to cAMP activators such as IBMX and Forskolin enhanced PHH attachment. Activation of EPAC2 increased PHH attachment and induced bile canaliculi formation in iPS-derived hepatocytes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jieying Yang, Yue Huang, Mengjia Song, Qiuzhong Pan, Jingjing Zhao, Junyi He, Dijun Ouyang, Chaopin Yang, Yulong Han, Yan Tang, Qijing Wang, Jia He, Yongqiang Li, Hao Chen, Desheng Weng, Tong Xiang, JianChuan Xia
Summary: This study reveals the significant role of SPC25 in hepatocellular carcinoma (HCC) progression and its correlation with disease severity and poor survival. Mechanistically, SPC25 promotes DNA damage and activates the DNA-PK/Akt/Notch1 signaling cascade, leading to the regulation of HCC cell proliferation and stemness program. These findings provide potential biomarkers for predicting HCC progression and poor survival, as well as therapeutic targets for HCC patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Luchao Li, Shuo Zhao, Zhengfang Liu, Nianzhao Zhang, Shuo Pang, Jikai Liu, Cheng Liu, Yidong Fan
Summary: The long-term use of sunitinib may promote metastasis in RCC, and for patients who have acquired resistance to sunitinib, treatment with sunitinib could accelerate disease progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jun Cheng, Yan Zhang, Rongjun Wan, Jun Zhou, Xin Wu, Qizhi Fan, Jingpeng He, Wei Tan, Youwen Deng
Summary: CEMIP is overexpressed in osteosarcoma and promotes the growth and metastasis of osteosarcoma cells by activating the Notch signaling pathway. Therefore, CEMIP may be an important therapeutic target in the progression of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yang Yang, Yizhe Wang, Xiaofang Che, Kezuo Hou, Jie Wu, Chunlei Zheng, Yang Cheng, Yunpeng Liu, Xuejun Hu, Jingdong Zhang
Summary: The study revealed that the integrin alpha 5/FAK/STAT3/AKT signaling pathway promotes icotinib resistance and malignancy in NSCLC cells. Targeting this pathway may provide a promising strategy to overcome drug resistance.
Article
Multidisciplinary Sciences
Zhen Zhang, Yun-xin Lu, Fangzhou Liu, Lingjie Sang, Chengyu Shi, Shaofang Xie, Weixiang Bian, Jie-cheng Yang, Zuozhen Yang, Lei Qu, Shi-yi Chen, Jun Li, Lu Yang, Qingfeng Yan, Wenqi Wang, Peifen Fu, Jianzhong Shao, Xu Li, Aifu Lin
Summary: It has been found that the lncRNA BREA2 stabilizes the Notch1 intracellular domain (NICD1) and promotes breast cancer metastasis, while WWP2 acts as an E3 ligase for NICD1 and suppresses breast cancer metastasis. BREA2 impairs the formation of the WWP2-NICD1 complex, leading to the activation of Notch signaling and lung metastasis. The loss of BREA2 sensitizes breast cancer cells to inhibition of Notch signaling and suppresses the growth of breast cancer patient-derived xenograft tumors, highlighting its therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Xinxing Wan, Liyong Zhu, Liling Zhao, Lin Peng, Jing Xiong, Wenjun Yang, Jingjing Yuan, Fang Liang, Keke Zhang, Ke Chen
Summary: The study identified human PER3 as a critical positive regulator of human adipose tissue-derived stromal cells adipogenesis, enhancing adipogenesis by repressing the Notch1 signaling pathway and interacting with hHSP90AA1.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shunji Kato, Atsushi Shiozaki, Michihiro Kudou, Hiroki Shimizu, Toshiyuki Kosuga, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Eiichi Konishi, Eigo Otsuji
Summary: The study revealed that TRPV2 promotes tumor migration and invasion in gastric cancer through the TGF-beta signaling pathway, and high expression of TRPV2 is associated with a poor prognosis in gastric cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)