Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer

Expression of A20 is reduced in pancreatic cancer tissues

(2012) Qing Wang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

(2012) Deepti Verma et al.   Pigment Cell & Melanoma Research

The Q705K Polymorphism in NLRP3 Is a Gain-of-Function Alteration Leading to Excessive Interleukin-1β and IL-18 Production

(2012) Deepti Verma et al.   PLoS One

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A20, ABIN-1/2, and CARD11 Mutations and Their Prognostic Value in Gastrointestinal Diffuse Large B-Cell Lymphoma

(2011) Gehong Dong et al.   CLINICAL CANCER RESEARCH

Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer

(2011) Annette Eyking et al.   GASTROENTEROLOGY

TNFAIP3 Maintains Intestinal Barrier Function and Supports Epithelial Cell Tight Junctions

(2011) Lauren E. Kolodziej et al.   PLoS One

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

(2010) Lynn Verstrepen et al.   BIOCHEMICAL PHARMACOLOGY

Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes

(2010) Vibeke Andersen et al.   BMC CANCER

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Impact of Toll-like receptor 4 polymorphisms on risk of cancer

(2010) Anton G. Kutikhin   HUMAN IMMUNOLOGY

Colon carcinogenesis: Learning from NF-κB and AP-1

(2010) Aristides G. Vaiopoulos et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

NF-ĸB and Bcl-3 Activation Are Prognostic in Metastatic Colorectal Cancer

(2010) Soham D. Puvvada et al.   ONCOLOGY

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

(2010) Anita B. Hjelmeland et al.   PLOS BIOLOGY

Allelotyping, Microsatellite Instability, and BRAF Mutation Analyses in Common and Atypical Melanocytic Nevi and Primary Cutaneous Melanomas

(2009) Pablo Uribe et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

(2009) K. Honma et al.   BLOOD

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23

(2009) Gisela Orozco et al.   HUMAN MOLECULAR GENETICS

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

(2009) Barbara A. Malynn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

New insights into the aetiology of colorectal cancer from genome-wide association studies

(2009) Albert Tenesa et al.   NATURE REVIEWS GENETICS

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

(2008) E Y M G Fung et al.   GENES AND IMMUNITY

Signature biomarkers in Crohn's disease: toward a molecular classification

(2008) R Arsenescu et al.   Mucosal Immunology

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS