Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity

AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers

(2015)   Oncotarget

The Critical Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis

(2012) A. Amini et al.   CURRENT CANCER DRUG TARGETS

MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression

(2011) Bing Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas

(2011) S Chatterjee et al.   BRITISH JOURNAL OF RADIOLOGY

Studies on the inhibition of feline EGFR in squamous cell carcinoma: Enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors

(2011) Gurå T. Bergkvist et al.   CANCER BIOLOGY & THERAPY

Hypoxia-Inducible Factor-1α Downregulation by Small Interfering RNA Inhibits Proliferation, Induces Apoptosis, and Enhances Radiosensitivity in Chemical Hypoxic Human Hepatoma SMMC-7721 Cells

(2011) Wei Yang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Biologie des radiations : avancées majeures et perspectives pour la radiothérapie

(2011) A. Joubert et al.   Cancer Radiotherapie

EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

(2011) G. Liccardi et al.   CANCER RESEARCH

miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression

(2011) Da-Peng Ding et al.   CARCINOGENESIS

microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2

(2011) Jing Nie et al.   CARCINOGENESIS

Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21

(2011) Pierre E. Queiroz de Oliveira et al.   CELL CYCLE

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture

(2011) Zhewei Zhang et al.   CELL CYCLE

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1

(2011) R. Wang et al.   CURRENT MEDICINAL CHEMISTRY

Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/BclXL-regulated mitochondrial apoptotic pathway

(2011) Ke-Wu Zeng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Cellular and Tumor Radiosensitivity is Correlated to Epidermal Growth Factor Receptor Protein Expression Level in Tumors Without EGFR Amplification

(2011) Ulla Kasten-Pisula et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

K-RAS(V12) Induces Autocrine Production of EGFR Ligands and Mediates Radioresistance Through EGFR-Dependent Akt Signaling and Activation of DNA-PKcs

(2011) Minjmaa Minjgee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Vital Roles of the Second DNA-binding Site of Rad52 Protein in Yeast Homologous Recombination

(2011) Naoto Arai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-372 Is Down-regulated and Targets Cyclin-dependent Kinase 2 (CDK2) and Cyclin A1 in Human Cervical Cancer, Which May Contribute to Tumorigenesis

(2011) Rui-Qing Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

(2011) Gabriela Imreh et al.   JOURNAL OF CELL SCIENCE

HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders

(2011) Hamid R. Rezvani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy

(2011) George T. Lountos et al.   JOURNAL OF STRUCTURAL BIOLOGY

EGFR inhibitors with concurrent thoracic radiation therapy for locally advanced non-small cell lung cancer

(2011) Yaping Xu et al.   LUNG CANCER

MicroRNAs dysregulated in breast cancer preferentially target key oncogenic pathways

(2011) Weng Khong Lim et al.   Molecular BioSystems

Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression

(2011) Uddalak Bharadwaj et al.   Molecular Cancer

Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants

(2011) Jr-Shiuan Yang et al.   MOLECULAR CELL

Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways

(2011) Emil Mladenov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Unraveling the mechanism of BRCA2 in homologous recombination

(2011) William K Holloman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

(2011) D Mérino et al.   ONCOGENE

Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair

(2011) P. Langerak et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MicroRNAs in Development and Disease

(2011) Danish Sayed et al.   PHYSIOLOGICAL REVIEWS

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

MicroRNA-22 Regulates Hypoxia Signaling in Colon Cancer Cells

(2011) Munekazu Yamakuchi et al.   PLoS One

Down-Regulation of EBV-LMP1 Radio-Sensitizes Nasal Pharyngeal Carcinoma Cells via NF-κB Regulated ATM Expression

(2011) Xiaoqian Ma et al.   PLoS One

Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4

(2011) Undurti N. Das   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

New Translational Possibilities for Microenvironmental Modulation of Radiosensitivity

(2011) Peter M. Glazer et al.   RADIATION RESEARCH

microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling

(2011) Kyung Min Lee et al.   RADIOTHERAPY AND ONCOLOGY

Radiation-induced hypothyroidism in head and neck cancer patients: A systematic review

(2011) Marjolein J. Boomsma et al.   RADIOTHERAPY AND ONCOLOGY

Individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage III NSCLC: A prospective population-based study

(2011) Dirk De Ruysscher et al.   RADIOTHERAPY AND ONCOLOGY

MicroRNAs in Mutagenesis, Genomic Instability, and DNA Repair

(2011) Dan-Avi Landau et al.   SEMINARS IN ONCOLOGY

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

DNA repair and synthetic lethality

(2011) Gong‐she Guo et al.   International Journal of Oral Science

microRNAs, an active and versatile group in cancers

(2011) Jeffrey Liu et al.   International Journal of Oral Science

Targeting inflammatory pathways for tumor radiosensitization

(2010) Amit Deorukhkar et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN

(2010) Zhang Chun-zhi et al.   BMC CANCER

Modulating the tumor microenvironment to increase radiation responsiveness

(2010) Jayashree Karar et al.   CANCER BIOLOGY & THERAPY

Activated PI3K/Akt/COX-2 Pathway Induces Resistance to Radiation in Human Cervical Cancer HeLa Cells

(2010) Shu Xia et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Altered fractionation in radiotherapy: From radiobiological rationale to therapeutic gain

(2010) Loredana G. Marcu   CANCER TREATMENT REVIEWS

AKT-ing via microRNA

(2010) Danish Sayed et al.   CELL CYCLE

MicroRNA-210: A unique and pleiotropic hypoxamir

(2010) Stephen Y. Chan et al.   CELL CYCLE

Microenvironmental Regulation of Glioblastoma Radioresponse

(2010) M. Jamal et al.   CLINICAL CANCER RESEARCH

Regulation of DNA strand exchange in homologous recombination

(2010) J. Thomas Holthausen et al.   DNA REPAIR

Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation

(2010) Stephany J. Veuger et al.   DNA REPAIR

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Improving the radiosensitivity of radioresistant and hypoxic glioblastoma

(2010) Jason P Sheehan et al.   Future Oncology

miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway

(2010) Fu Yang et al.   HEPATOLOGY

MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

(2010) Danish Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

(2010) Christopher J. Staples et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-mediated biological control

(2010) Jessica Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504

(2010) Wenwei Hu et al.   MOLECULAR CELL

Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM

(2010) Y Wang et al.   ONCOGENE

Cyclin-dependent kinase 1 expression is inhibited by p16INK4a at the post-transcriptional level through the microRNA pathway

(2010) W W Chien et al.   ONCOGENE

Targeting DNA-PKcs and ATM with miR-101 Sensitizes Tumors to Radiation

(2010) Dan Yan et al.   PLoS One

ATM is down-regulated by N-Myc-regulated microRNA-421

(2010) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486

(2010) E. M. Small et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity

(2010) Oliver Zschenker et al.   RADIOTHERAPY AND ONCOLOGY

Targeting Base Excision Repair as a Sensitization Strategy in Radiotherapy

(2010) Conchita Vens et al.   SEMINARS IN RADIATION ONCOLOGY

Targeting Nonhomologous End-Joining Through Epidermal Growth Factor Receptor Inhibition: Rationale and Strategies for Radiosensitization

(2010) Bipasha Mukherjee et al.   SEMINARS IN RADIATION ONCOLOGY

DNA Repair Targeting and Radiotherapy: A Focus on the Therapeutic Ratio

(2010) John Thoms et al.   SEMINARS IN RADIATION ONCOLOGY

Use of γH2AX and Other Biomarkers of Double-Strand Breaks During Radiotherapy

(2010) Ali Sak et al.   SEMINARS IN RADIATION ONCOLOGY

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs: new players in the DNA damage response

(2010) H. Hu et al.   Journal of Molecular Cell Biology

The role of BRCA1 in DNA damage response

(2010) Jiaxue Wu et al.   Protein & Cell

Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

(2009) H Harada et al.   BRITISH JOURNAL OF CANCER

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

(2009) M. E. Crosby et al.   CANCER RESEARCH

microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

(2009) P. Wang et al.   CANCER RESEARCH

Increasing Sensitivity to Radiotherapy and Chemotherapy by Using Novel Biological Agents that Alter the Tumor Microenvironment

(2009) E. Shinohara et al.   CURRENT MOLECULAR MEDICINE

Tumor Hypoxia as a Modifier of DNA Strand Break and Cross-Link Repair

(2009) Norman Chan et al.   CURRENT MOLECULAR MEDICINE

miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A

(2009) X. Yang et al.   GENES & DEVELOPMENT

Radiation-Induced Interleukin-6 Expression Through MAPK/p38/NF-κB Signaling Pathway and the Resultant Antiapoptotic Effect on Endothelial Cells Through Mcl-1 Expression With sIL6-Rα

(2009) Chia-Hung Chou et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

let-7Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts

(2009) Aster Legesse-Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

(2009) Ashish Lal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities

(2009) Urszula Florczak et al.   RADIOTHERAPY AND ONCOLOGY

miR-34a as part of the resistance network in chronic lymphocytic leukemia

(2008) T. Zenz et al.   BLOOD

PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro

(2008) M TOULANY et al.   DNA REPAIR

Correlation Between Tumor Growth Delay and Expression of Cancer and Host VEGF, VEGFR2, and Osteopontin in Response to Radiotherapy

(2008) Timothy D. Solberg et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM

(2008) Laura Fontana et al.   PLoS One

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

(2007) V. Stagni et al.   BLOOD