Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms

An Emerging Strategy for Cancer Treatment Targeting Aberrant Glycogen Synthase Kinase 3β

(2012) Katsuyoshi Miyashita et al.   Anti-Cancer Agents in Medicinal Chemistry

A Combination of DR5 Agonistic Monoclonal Antibody with Gemcitabine Targets Pancreatic Cancer Stem Cells and Results in Long-term Disease Control in Human Pancreatic Cancer Model

(2010) N. V. Rajeshkumar et al.   MOLECULAR CANCER THERAPEUTICS

Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis

(2010) Rachel Spokoini et al.   MOLECULAR ENDOCRINOLOGY

Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy

(2009) Shadi Mamaghani et al.   BMC CANCER

Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers

(2009) R R Weichselbaum et al.   CANCER GENE THERAPY

Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells

(2009) Ravi P. Sahu et al.   CARCINOGENESIS

Deregulated GSK3  Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase

(2009) W. Mai et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells

(2008) Eléonore Beurel et al.   BIOCHEMICAL PHARMACOLOGY

I B  Kinase Inhibitor IKI-1 Conferred Tumor Necrosis Factor   Sensitivity to Pancreatic Cancer Cells and a Xenograft Tumor Model

(2008) Y. Zhang et al.   CANCER RESEARCH

Glycogen Synthase Kinase 3  Regulates Cell Death Induced by Synthetic Triterpenoids

(2008) R. Vene et al.   CANCER RESEARCH

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 /  in Pancreatic Cancer

(2008) W. Wilson et al.   CANCER RESEARCH

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor- B, and Glucose Regulation

(2008) S. Kotliarova et al.   CANCER RESEARCH

Identification of an antiapoptotic protein complex at death receptors

(2008) M Sun et al.   CELL DEATH AND DIFFERENTIATION

Nuclear Factor- B p65/relA Silencing Induces Apoptosis and Increases Gemcitabine Effectiveness in a Subset of Pancreatic Cancer Cells

(2008) X. Pan et al.   CLINICAL CANCER RESEARCH

Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs

(2008) Ana Martinez   MEDICINAL RESEARCH REVIEWS

Apoptotic pathways in pancreatic ductal adenocarcinoma

(2008) Rainer Hamacher et al.   Molecular Cancer

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE