Article
Food Science & Technology
Lei Zhang, Zhuo Qu, Aiwei Song, Jianhong Yang, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: The study demonstrated that garlic oil is effective in inhibiting tobacco carcinogen-induced lung cancer and protecting cells from damage, suggesting its potential as a novel candidate agent for chemoprevention of lung cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jiahui Tian, Wenli Zhao, Yanran Wu, Ying Shi, Jianqiang Yu, Wannian Zhang, Chengguo Xing, Chunlin Zhuang, Zhuo Qu
Summary: The study demonstrates that diallyl disulfide (DADS) found in garlic can significantly reduce the incidence of lung cancer. DADS exerts its chemopreventive effect through multiple mechanisms, including the inhibition of tumor formation and suppression of inflammation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Environmental Sciences
Mengyuan Li, Hong Liu, Hua Shao, Peng Zhang, Min Gao, Li Huang, Pingping Shang, Qiao Zhang, Wei Wang, Feifei Feng
Summary: In this study, it was found that glyburide could attenuate lung tumorigenesis induced by B(a)p/LPS in non-diabetes mice by inhibiting NLRP3 inflammasome. Glyburide also reduced inflammatory changes and decreased tumor nest numbers in histopathological examination.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Oncology
Dan Shi, Jingjing Wu, Youqile Wu, Xiaojing Lin, Cai Xu, Xuemei Lian
Summary: Obesity induced by high-fat diet was found to promote lung tumorigenesis in C57BL/6J mice, with leptin-mediated activation of the PI3K/Akt/mTOR/STAT3 pathway likely playing a key role in this mechanism.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiazhen Zhou, Xinchao Guan, Enwu Xu, Jiaxin Zhou, Rui Xiong, Qiaoyuan Yang
Summary: In this study, the high expression of chimeric RNA RRM2-C2orf48 was found to be significantly correlated with lymph node metastasis, distant metastasis, TNM stage, and smoking in lung cancer patients and cell lines. Overexpressing RRM2-C2orf48 promoted cell growth and accelerated the NNK-induced lung cancer process. The knockdown of RRM2-C2orf48 inhibited the growth of RRM2-C2orf48-overexpressing cells, and miR-219a-2-3p was identified as a potential target of RRM2-C2orf48 in lung cancer.
Article
Toxicology
Rui Xiong, Yiheng Du, Sili Chen, Tao Liu, Xiangyu Ding, Jiaxin Zhou, Zhi Wang, Qiaoyuan Yang
Summary: This study found that 5mC modification is involved in the malignant transformation process induced by NNK, and abnormal hypermethylation of the ADIRF promoter region inhibits ADIRF expression. Additionally, ADIRF overexpression can suppress the proliferation, migration, and invasion of cells. Furthermore, demethylation of the ADIRF promoter region inhibits cell proliferation, migration, and invasion, and increases apoptosis ability.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Kuan Shen, Xinyi Zhou, Li Hu, Jian Xiao, Quan Cheng, Yuanhang Wang, Kanghui Liu, Hao Fan, Zekuan Xu, Li Yang
Summary: This study revealed for the first time that the rs15285 polymorphism increases the risk of gastric cancer (GC) and is associated with a poorer prognosis. Bioinformatics analysis and in vitro experiments further demonstrated that this polymorphism may affect the binding of miRNAs to LPL, resulting in increased expression and promoting GC progression.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Critical Care Medicine
Richard J. Allen, Justin M. Oldham, David A. Jenkins, Olivia C. Leavy, Beatriz Guillen-Guio, Carl A. Melbourne, Shwu-Fan Ma, Jonathan Jou, John S. Kim, William A. Fahy, Eunice Oballa, Richard B. Hubbard, Vidya Navaratnam, Rebecca Braybrooke, Gauri Saini, Katy M. Roach, Martin D. Tobin, Nik Hirani, Moira K. B. Whyte, Naftali Kaminski, Yingze Zhang, Fernando J. Martinez, Angela L. Linderholm, Ayodeji Adegunsoye, Mary E. Strek, Toby M. Maher, Philip L. Molyneaux, Carlos Flores, Imre Noth, R. Gisli Jenkins, Louise Wain
Summary: In this study, a genetic variant associated with disease progression in idiopathic pulmonary fibrosis (IPF) was identified, and the PKN2 gene was proposed as a potential target for novel therapeutic approaches. This finding provides insights into the biological mechanisms underlying IPF and offers potential implications for its treatment.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Chemistry, Medicinal
Santanu Hati, Qi Hu, Zhiguang Huo, Junxuan Lu, Chengguo Xing
Summary: The study found that the unnatural enantiomer of DHM is more effective than the natural enantiomer, the methylenedioxy functional moiety does not tolerate modifications, while other functional groups can accommodate various changes. Analogues with high structural similarity to DHM but different efficacy in reducing NNK-induced DNA damage have been identified, serving as chemical probes to elucidate the mechanisms of DHM in blocking NNK-induced lung carcinogenesis.
Article
Oncology
Ayse Ece Gulen, Rakesh Rudraboina, Mohammad Tarique, Vahap Ulker, Haval Shirwan, Esma S. S. Yolcu
Summary: Immunotherapy utilizing checkpoint inhibitors has shown remarkable success in cancer treatment. This study investigates the potential of using a specific immune co-stimulatory receptor, CD137, to enhance immune activation and inhibit tumor growth. The researchers generated a soluble form of the CD137 ligand, which effectively inhibited the development of lung tumors in mice induced by a tobacco carcinogen. The study suggests that this immune co-stimulation approach can be extended to other cancer types.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Ayaz Shahid, Mengbing Chen, Steven Yeung, Cyrus Parsa, Robert Orlando, Ying Huang
Summary: This study investigated the effects of a commercial Ganoderma lucidum product (GLSF) on tobacco smoke carcinogen-induced lung toxicity and carcinogenesis. GLSF was found to inhibit malignant transformation in human bronchial epithelial cells and reduce lung toxicity and tumor development in mice. Therefore, GLSF may be used to alleviate tobacco smoke carcinogen-induced lung toxicity and carcinogenesis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Wang, Zhuo Lu, Tianyu Han, Yanan Wang, Mingxi Gan, Jian-Bin Wang
Summary: This study reveals a novel mechanism of GAC regulation through acetylation and ubiquitination in non-small cell lung cancer, suggesting that targeting this pathway could be a promising strategy for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Chandra Lebovitz, Nicole Wretham, Maryam Osooly, Katy Milne, Tia Dash, Shelby Thornton, Basile Tessier-Cloutier, Paalini Sathiyaseelan, Svetlana Bortnik, Nancy Erro Go, Elizabeth Halvorsen, Rachel A. Cederberg, Norman Chow, Nancy Dos Santos, Kevin L. Bennewith, Brad H. Nelson, Marcel B. Bally, Wan L. Lam, Sharon M. Gorski
Summary: The study reveals that overactivity of LRRK2 is associated with Parkinson's disease, while decreased expression is linked to lung adenocarcinoma. In LUAD patients, reduced LRRK2 expression is significantly connected to ongoing smoking, worse survival, and less differentiated tumors.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Yapeng Li, Lanlan Wei, Lanye He, Jiahui Sun, Nanyang Liu
Summary: The meta-analysis suggests an association between IFITM3 rs12252 gene polymorphisms and COVID-19 susceptibility, with the rs12252-C variant being particularly critical for severity.
JOURNAL OF INFECTION
(2022)
Article
Medicine, Research & Experimental
Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng
Summary: SETD2 is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. The loss of SETD2 function promotes tumorigenesis by activating intronic enhancers to drive oncogenic transcriptional output, including the KRAS transcriptional signature and PRC2-repressed targets. Additionally, SETD2 loss sensitizes KRAS-mutant lung cancer to inhibition of histone chaperones, the FACT complex, or transcriptional elongation, suggesting potential therapeutic strategies for SETD2 mutant cancers.
Review
Microbiology
Stephanie L. Collins, Jonathan C. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson
Summary: This Review discusses host-microbiota interactions and their impact on bile acid metabolism and composition. The gut microbiota plays a crucial role in bile acid metabolism, with diverse biological roles for bile acids being discovered. External factors such as antibiotics and diet also influence bile acid composition. Understanding the impact of bile acid signaling networks in different organs is increasingly important for the development of targeted therapeutics.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew
Summary: Intestinal homeostasis is maintained through balanced cellular turnover, proliferation, differentiation, and self-renewal, but can be influenced by the aryl hydrocarbon receptor (AHR). The AHR plays a role in small intestinal gene expression and cellular repertoire remodeling, promoting intestinal resilience. Genetic ablation of Ahr impairs lineage commitment and differentiation, while exposure to AHR ligands reverses these effects.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Sougat Misra, Tai-Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu
Summary: Macrophages play a crucial role in inflammation and its resolution. Selenium and selenoproteins, which contain the amino acid selenocysteine, are essential for the functions of macrophages. In this study, the researchers investigated the role of SELENOW, a highly expressed selenoprotein, in inflammation using Selenow knock-out macrophages. The results suggest that SELENOW is involved in redox processes and bioenergetics during inflammation and its resolution.
Article
Biochemistry & Molecular Biology
Jonathan A. A. Young, Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. D. Patterson, Edward O. O. List, Darlene E. E. Berryman, John J. J. Kopchick
Summary: Growth hormone (GH) affects protein metabolism and alters circulating levels of glycine and hydroxyproline. GH abnormality, such as increased GH action or GH resistance, leads to changes in amino acid concentrations in plasma and feces. Acute GH treatment decreases liver gene expression of glycine metabolism genes and serum glycine in mice.
Article
Biochemistry & Molecular Biology
Fangcong Dong, Iain A. Murray, Andrew Annalora, Denise M. Coslo, Dhimant Desai, Krishne Gowda, Jian Yang, Dingbowen Wang, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Andrew D. Patterson, Craig Marcus, Gary H. Perdew
Summary: A certain diet can enhance the activity of the aryl hydrocarbon receptor (AHR) in the intestinal tract, which is responsible for maintaining intestinal barrier homeostasis. This is possibly achieved through the role of certain dietary substrates as CYP1A1/1B1 substrates, which increase the half-life of potent AHR ligands. The gut bacterial metabolite urolithin A (UroA) has been identified as one of these substrates, and its intake can lead to increased AHR activity in key barrier tissues.
Article
Toxicology
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson
Summary: This study investigates the effects of a persistent organic pollutant on the enteric nervous system, finding that it leads to delayed intestinal motility and neuronal damage, thereby affecting gastrointestinal function.
TOXICOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Summary: Bile salt hydrolase (BSH) in Bacteroides is associated with the development of colorectal cancer (CRC) by activating the beta-catenin/CCL28 pathway and promoting the generation of immunosuppressive T-reg cells. Inhibition of BSH activity could slow down CRC progression and serve as a potential target for CRC prevention and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg
Summary: A novel AHR modulator, 2-amino-4-methyl-benzothiazole, was predicted, identified, and characterized in white button mushrooms using a molecular networking approach. Cell-based assays showed that this compound has agonistic activity and upregulates CYP1A1 expression. These findings demonstrate the potential of molecular networking in identifying novel receptor modulators from natural products.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Summary: Long-term ligand activation of PPARa in mice causes hepatocarcinogenesis, while hepatocarcinogenesis is diminished in Ppara-null and PPARA-humanized mice. Lipidomic analyses showed elevated levels of hepatic linoleic acid and overall fatty liver in Ppara-null and PPARA-humanized mice. The accumulation of linoleic acid and loss of CD4+ T cells suggest a new role for PPARa in age-associated hepatocarcinogenesis.
Article
Oncology
Sangshan Tian, Devendra Paudel, Fuhua Hao, Rabin Neupane, Rita Castro, Andrew D. Patterson, Amit K. Tiwari, K. Sandeep Prabhu, Vishal Singh
Summary: This study reveals that supplementation of diet with refined inulin leads to abnormal succinate accumulation in the intestinal lumen, which contributes to promoting colon inflammation and tumorigenesis.
Article
Cell Biology
Beng San Yeoh, Rachel M. Golonka, Piu Saha, Mrunmayee R. Kandalgaonkar, Yuan Tian, Islam Osman, Andrew D. Patterson, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Summary: Congenital portosystemic shunt (PSS) occurs sporadically in C57BL/6 J mice, leading to abnormal serologic, metabolic, and physiologic parameters. To reliably and efficiently identify PSS mice, we explored simple, inexpensive, and noninvasive urine-based screening tests. Metabolome profiling revealed elevated levels of Krebs cycle intermediates in the urine of PSS mice, which we utilized to develop three colorimetric assays: urinary iron-chelation, pH strip, and phenol red assays. These assays provide a feasible and noninvasive method for diagnosing PSS in mice, aiding biomedical research by stratifying PSS mice and minimizing confounding factors.
Article
Neurosciences
Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Yuan Tian, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew
Summary: The aryl hydrocarbon receptor (AHR) plays important roles in xenobiotic metabolism, immune function, and tissue homeostasis. The regulation of AHR activity by endogenous ligands is still poorly understood. In this study, we identified and quantified 6 tryptophan metabolites that individually activate AHR in mouse and human serum. These metabolites are not significantly metabolized by CYP1A1/1B1, unlike the potent endogenous AHR ligand 6-formylindolo[3,2b]carbazole. Our results suggest that these tryptophan metabolites may contribute to constitutive but low level systemic AHR activity in humans.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)
Article
Neurosciences
Ethan W. Morgan, Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Trenton Wolfe, Reece Erickson, Krishne Gowda, Shantu G. Amin, Kristina S. Petersen, Penny M. Kris-Etherton, Craig B. Marcus, Seth T. Walk, Andrew D. Patterson, Gary H. Perdew
Summary: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that regulates various cellular functions. Tryptophan metabolites derived from host and bacterial metabolism act as AHR activators. This study investigates the presence and metabolic source of these metabolites and examines the biological relevance of circulating tryptophan metabolites. The results improve our understanding of homeostatic AHR activity and related diseases.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Alexis Bretin, Jun Zou, Beng San Yeoh, Vu L. Ngo, Shawn Winer, Daniel A. Winer, Lavanya Reddivari, Michael Pellizzon, William A. Walters, Andrew D. Patterson, Ruth Ley, Benoit Chassaing, Matam Vijay-Kumar, Andrew T. Gewirtz
Summary: Psyllium protects against experimental colitis by altering bile acid metabolism and activating FXR, which suppresses pro-inflammatory signaling.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernandez-Salguero, Xavier Coumoul, Andrew D. Patterson
Summary: The aryl hydrocarbon receptor (AHR) senses low-molecular-weight molecule signals from environmental exposures, the microbiome, and host metabolism. It plays important roles in host homeostasis, chronic disease development, and responses to toxic insults. Recent research has shown that AHR is a promising target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting aimed to explore the potential therapeutic applications based on our understanding of this receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)