Article
Chemistry, Medicinal
Dipak Walunj, Ebaston Thankarajan, Chandrashekhar Prasad, Helena Tuchinsky, Simone Baldan, Michael Y. Sherman, Leonid Patsenker, Gary Gellerman
Summary: The chimeric molecules created in this study successfully enhanced the inhibition activity towards DSB induced by Topo II, leading to more DSB and accelerated cancer cell killing. These chimeras exhibited higher antiproliferative activity compared to traditional treatment components, accumulated at tumor sites and showed stronger tumor suppressing activities.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Business, Finance
Shikong Luo, Xinyan Yan, Haoyi Yang
Summary: Research on the prediction of stock returns using the dividend-price ratio has shown mixed empirical results. A novel approach that considers smooth shifts in the steady state outperforms traditional sharp break methods in both in-sample and out-of-sample tests, with Monte Carlo experiments supporting this finding. This new approach offers a simple and effective way to improve return predictability based on economic motivations.
INTERNATIONAL REVIEW OF ECONOMICS & FINANCE
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Elie Dolgin
Summary: Protective encapsulating devices and gene-editing technologies may eliminate the need for antirejection drugs in stem-cell-derived therapies for diabetes.
NATURE BIOTECHNOLOGY
(2022)
Editorial Material
Physics, Applied
Astrid Eichhorn
Summary: Reporting carbon emissions is important, but taking action is crucial. Even with imperfect evidence, scientists and institutions can make a difference and bring about lasting change.
NATURE REVIEWS PHYSICS
(2023)
Review
Chemistry, Medicinal
Mahdi Vajdi, Pouria Sefidmooye Azar, Ata Mahmoodpoor, Farzaneh Dashti, Sarvin Sanaie, Fateme Kiani Chalmardi, Arash Karimi
Summary: This article systematically reviews the effects and mechanisms of resveratrol in the treatment of septic shock, and the results show that resveratrol can reduce the complications of sepsis by affecting inflammatory pathways, oxidative stress, and modulating immune responses. Future human randomized clinical trials are necessary due to the promising therapeutic effects of resveratrol on sepsis complications and the lack of clinical trials in this regard.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemical Research Methods
Kellen R. Rodriguez, Namita Sarraf, Lulu Qian
Summary: DNA-based neural networks, including winner-take-all and loser-take-all circuits, are capable of molecular pattern recognition tasks. These circuits utilize lateral inhibition and competition across neurons to simplify molecular pattern recognition and eliminate the need for dual-rail representation. Loser-take-all circuits, in particular, are useful for recognizing noisy molecular patterns based on least similarities to a set of memories.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Emmanouilidis, Natalia Fili, Alexander W. Cook, Yukti Hari-Gupta, Alia dos Santos, Lin Wang, Marisa L. Martin-Fernandez, Peter J. I. Ellis, Christopher P. Toseland
Summary: Mammalian cells are constantly exposed to various DNA damaging events, leading to the activation of DNA repair pathways. Cas9-based genomic intervention allows for induced DSBs at defined quantities and locations across the human genome, utilizing custom-designed promiscuous guide RNAs based on in silico predictions. This provides a generic, low-cost, and rapid methodology for inducing controlled DNA damage in cell culture models.
Review
Biochemistry & Molecular Biology
Mariarosaria De Falco, Mariarita De Felice
Summary: DNA repair pathways are crucial for counteracting various types of DNA damages, with distinct cellular responses triggered upon detection of damage leading to the choice of specific repair mechanisms to maintain genome stability. The appropriate choice of repair pathways is essential to prevent genome rearrangements and the development of various human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Green & Sustainable Science & Technology
Ju Young Lee, Sandra Waddock
Summary: This paper discusses the unique role of transformation catalysts in promoting transformative changes at the systems level, identifying four key characteristics of catalysts: transformation agendas, catalytic actions, acknowledgment of problem status quo, and systems orientation. Through the analysis of TCs, a conceptual framework is established to understand the nature of transformative catalytic action and determine the elements necessary for their work.
Review
Biochemistry & Molecular Biology
Roxana Pop, Adela Daescu, Dumitrita Rugina, Adela Pintea
Summary: This article mainly introduces the therapeutic potential of resveratrol for eye diseases, as well as its influencing factors, and discusses the relevant literature and research progress, providing a reference for further studies on resveratrol.
Review
Food Science & Technology
Pan Wang, Runze Shang, Yue Ma, Dan Wang, Wenting Zhao, Fang Chen, Xiaosong Hu, Xiaoyan Zhao
Summary: Resveratrol, a natural polyphenolic compound found in grapes, berries, and red wine, has been shown to exhibit anticancer activities. Understanding its metabolic characteristics and mechanisms, particularly its effects on gut microbiota and the role of RSV metabolites, is crucial for exploring its potential as a cancer therapy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Ryan S. Czarny, Alexander N. Ho, P. Shing Ho
Summary: Classical hydrogen bonds have long been the main non-covalent interaction used by chemists and chemical engineers to design and control compound structures, but recently non-classical non-covalent interactions such as halogen bonds have also emerged as important tools. Research is focused on understanding the role of halogen bonds in biological systems and utilizing them to control the structures, stabilities, and activities of biomolecules.
Article
Neurosciences
Alejandro Sanchez-Melgar, Sonia Munoz-Lopez, Jose Luis Albasanz, Mairena Martin
Summary: Gliomas are the most common and aggressive primary tumors in the central nervous system, while resveratrol, a natural polyphenol, shows antitumoral potential, possibly through regulating adenosine metabolism and adenosine receptors.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Chemistry, Multidisciplinary
Christine M. Le
Summary: This article examines the role of 2-[18F]fluoro-2-deoxyglucose and highlights how this radioactive sugar could be instrumental in saving lives.
Article
Environmental Sciences
Zhihong Chen, Jiayi Xie, Qing Li, Keqi Hu, Zongying Yang, Hang Yu, Yungang Liu
Summary: The study found that 2-ethylhexyl diphenyl phosphate (EHDPP) could be activated by several human CYP enzymes, leading to potent clastogenic effects, with CYP3A4 being a major activating enzyme.
ENVIRONMENTAL POLLUTION
(2021)
Editorial Material
Oncology
Susanne A. Gatz, Janet M. Shipley
CLINICAL CANCER RESEARCH
(2015)
Article
Genetics & Heredity
Susanne A. Gatz, Daniela Salles, Eva-Maria Jacobsen, Thilo Doerk, Tobias Rausch, Sevtap Aydin, Harald Surowy, Meta Volcic, Walther Vogel, Klaus-Michael Debatin, Adrian M. Stuetz, Klaus Schwarz, Ulrich Pannicke, Timo Hess, Jan O. Korbel, Ansgar S. Schulz, Johannes Schumacher, Lisa Wiesmueller
Article
Oncology
Susanne A. Gatz, Khin Thway, Henry Mandeville, Cyrus Kerawala, David MacVicar, Julia Chisholm
PEDIATRIC BLOOD & CANCER
(2015)
Review
Medicine, General & Internal
Gill Norman, Debra Fayter, Kate Lewis-Light, Julia Chisholm, Kieran McHugh, Daniel Levine, Meriel Jenney, Henry Mandeville, Suzanne Gatz, Bob Phillips
Article
Oncology
Elisa Izquierdo, Lina Yuan, Sally George, Michael Hubank, Chris Jones, Paula Proszek, Janet Shipley, Susanne A. Gatz, Caedyn Stinson, Andrew S. Moore, Steven C. Clifford, Debbie Hicks, Janet C. Lindsey, Rebecca M. Hill, Thomas S. Jacques, Jane Chalker, Khin Thway, Simon O'Connor, Lynley Marshall, Lucas Moreno, Andrew Pearson, Louis Chesler, Brian A. Walker, David Gonzalez De Castro
Article
Oncology
Daniel A. Morgenstern, Darren Hargrave, Lynley V. Marshall, Susanne A. Gatz, Giuseppe Barone, Tracey Crowe, Kathy Pritchard-Jones, Stergios Zacharoulis, Donna L. Lancaster, Sucheta J. Vaidya, Julia C. Chisholm, Andrew D. J. Pearson, Lucas Moreno
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2014)
Article
Oncology
Antonio Romo-Morales, Ewa Aladowicz, Julian Blagg, Susanne A. Gatz, Janet M. Shipley
PEDIATRIC BLOOD & CANCER
(2019)
Article
Oncology
Sally L. George, Elisa Izquierdo, James Campbell, Eleni Koutroumanidou, Paula Proszek, Sabri Jamal, Deborah Hughes, Lina Yuan, Lynley V. Marshall, Fernando Carceller, Julia C. Chisholm, Sucheta Vaidya, Henry Mandeville, Paola Angelini, Ajla Wasti, Tomas Bexelius, Khin Thway, Susanne A. Gatz, Matthew Clarke, Bissan Al-Lazikani, Giuseppe Barone, John Anderson, Deborah A. Tweddle, David Gonzalez, Brian A. Walker, Jack Barton, Sarita Depani, Jessica Eze, Saira W. Ahmed, Lucas Moreno, Andrew Pearson, Janet Shipley, Chris Jones, Darren Hargrave, Thomas S. Jacques, Michael Hubank, Louis Chesler
EUROPEAN JOURNAL OF CANCER
(2019)
Review
Oncology
Susanne A. Gatz, Ewa Aladowicz, Michela Casanova, Julia C. Chisholm, Pamela R. Kearns, Simone Fulda, Birgit Geoerger, Beat W. Schaefer, Janet M. Shipley
FRONTIERS IN ONCOLOGY
(2019)
Editorial Material
Oncology
Olga Nigro, Andrea Ferrari, Michela Casanova, Daniel Orbach, Amaury Leruste, Susanne A. Gatz, Didier Frappaz, Maura Massimino
Summary: Pediatric cancers do not show the same enthusiasm for immunotherapy as adult cancers, but progress is being made in understanding PD-L1 expression, tumor mutational burden, and microsatellite instability in pediatric cancers. The side effects of immunotherapy are important considerations, and the unknown risks of late irAEs in pediatric patients are a concern.
Article
Oncology
Anne-Sophie Defachelles, Emilie Bogart, Michela Casanova, Johannes H. M. Merks, Gianni Bisogno, Giuseppina Calareso, Soledad Gallego Melcon, Susanne Andrea Gatz, Marie-Cecile Le Deley, Kieran McHugh, Alicia Probst, Nathalie Rocourt, Rick R. van Rijn, Keith Wheatley, Veronique Minard-Colin, Julia C. Chisholm
Summary: The VIT-0910 trial aimed to evaluate the efficacy and safety of vincristine-irinotecan with and without temozolomide in relapsed or refractory rhabdomyosarcoma. The study found that the addition of temozolomide improved chemotherapy efficacy for patients with relapsed RMS, with manageable increase in toxicity. VIT is considered the new standard treatment in these patients in the European paediatric Soft Tissue Sarcoma Group.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Reda Stankunaite, Sally L. George, Lewis Gallagher, Sabri Jamal, Ridwan Shaikh, Lina Yuan, Debbie Hughes, Paula Z. Proszek, Paul Carter, Grzegorz Pietka, Timon Heide, Chela James, Haider Tari, Claire Lynn, Neha Jain, Laura Rey Portela, Tony Rogers, Sucheta J. Vaidya, Julia C. Chisholm, Fernando Carceller, Elwira Szychot, Henry Mandeville, Paola Angelini, Angela B. Jesudason, Michael Jackson, Lynley Marshall, Susanne A. Gatz, John Anderson, Andrea Sottoriva, Louis Chesler, Michael Hubank
Summary: This study developed a clinically relevant NGS capture panel and workflow for detecting low frequency genetic variants in cell-free DNA from children with solid tumors. The method showed high sensitivity, specificity, repeatability, and reproducibility. The potential for clinical application was demonstrated in childhood cancer patients, with a close correlation between cfDNA events and treatment response observed.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Oncology
Anne-Sophie Defachelles, Emilie Bogart, Michela Casanova, Johannes H. M. Merks, Gianni Bisogno, Giuseppina Calareso, Soledad Gallego Melcon, Susanne Andrea Gatz, Marie-Cecile Le Deley, Kieran McHugh, Alicia Probst, Nathalie Rocourt, Rick R. van Rijn, Veronique Minard-Colin, Julia C. Chisholm
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Christopher I. Milton, Joanna Selfe, Ewa Aladowicz, Stella Y. K. Man, Carolina Bernauer, Edoardo Missiaglia, Zoe S. Walters, Susanne A. Gatz, Anna Kelsey, Melanie Generali, Gary Box, Melanie Valenti, Alexis de Haven-Brandon, David Galiwango, Angela Hayes, Matthew Clarke, Elisa Izquierdo, David Gonzalez De Castro, Florence I. Raynaud, Vladimir Kirkin, Janet M. Shipley
Summary: High expression of FGFR2 and FGF7 in fusion-gene-positive rhabdomyosarcomas correlates with increased sensitivity of the cells and forms a novel autocrine loop mechanism. FGFR inhibitor NVP-BGJ398 reduces cell viability and shows synergistic effects with SN38.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Olivia Ruhen, Nathalie S. M. Lak, Janine Stutterheim, Sara G. Danielli, Mathieu Chicard, Yasmine Iddir, Alexandra Saint-Charles, Virginia Di Paolo, Lucia Tombolan, Susanne A. Gatz, Ewa Aladowicz, Paula Proszek, Sabri Jamal, Reda Stankunaite, Deborah Hughes, Paul Carter, Elisa Izquierdo, Ajla Wasti, Julia C. Chisholm, Sally L. George, Erika Pace, Louis Chesler, Isabelle Aerts, Gaelle Pierron, Sakina Zaidi, Olivier Delattre, Didier Surdez, Anna Kelsey, Michael Hubank, Paolo Bonvini, Gianni Bisogno, Angela Di Giannatale, Gudrun Schleiermacher, Beat W. Sch Safer, Godelieve A. M. Tytgat, Janet Shipley
Summary: This study aimed to explore the feasibility of using ctDNA in plasma as a marker for determining disease burden and treatment response in rhabdomyosarcomas (RMS). The results showed the presence of ctDNA in both mouse models and patients, and it was correlated with tumor burden and treatment response. This suggests that ctDNA has the potential to serve as a minimally invasive biomarker. Further evaluation through pre-clinical assessment using mouse models and prospective clinical trials in patients is warranted to validate these findings.
JCO PRECISION ONCOLOGY
(2022)