Article
Urology & Nephrology
Lingling Xu, Jin Liu, Dongling Li, Hua Yang, Yang Zhou, Junwei Yang
Summary: Chronic kidney disease (CKD) is prevalent among the elderly population in China, with associations found with age, hypertension, elevated triglycerides, and fasting blood glucose levels.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Endocrinology & Metabolism
Florian G. Scurt, Maximilian J. Ganz, Carolin Herzog, Katrin Bose, Peter R. Mertens, Christos Chatzikyrkou
Summary: The prevalence of kidney disease is increasing rapidly worldwide due to rising rates of obesity, diabetes, and metabolic syndrome. These conditions place a significant financial burden on healthcare systems. Despite treatment options, there is still a significant risk of progression to end-stage renal disease in high-risk obese and diabetic populations. The metabolic syndrome adversely affects the development and progression of chronic kidney failure. Understanding the underlying mechanisms of metabolic syndrome-associated kidney disease is important in developing strategies for prevention and slowing disease progression.
Review
Medicine, General & Internal
Xu Li, Qichen Liang, Junfeng Zhong, Liangying Gan, Li Zuo
Summary: This meta-analysis examined the relationship between metabolic syndrome (MetS) and renal dysfunction. The results showed that MetS and its components were associated with an increased risk of renal dysfunction, including rapid decline in eGFR, new-onset CKD, and ESRD. Elevated blood pressure had the highest risk, while impaired fasting glucose had the lowest risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Wen Niu, Hugo You-Hsien Lin, I-Ching Kuo, Yen-Yi Zhen, Eddy-Essen Chang, Feng-Ching Shen, Yi-Wen Chiu, Jer-Ming Chang, Chi-Chih Hung, Shang-Jyh Hwang
Summary: The study found that uric acid (UA) is elevated in metabolic syndrome (MS) and diabetes (DM). UA is associated with obesity, inflammation markers, and renal function. High levels of UA are associated with worse renal outcomes in non-MS/DM patients, but not in MS/DM patients. Redefining MS to include hyperuricemia does not predict renal outcomes.
Article
Obstetrics & Gynecology
Jessica A. Grieger, Shalem Y. Leemaqz, Emma J. Knight, Luke E. Grzeskowiak, Lesley M. McCowan, Gustaaf A. Dekker, Claire T. Roberts
Summary: The study evaluated the contributions of metabolic syndrome and known risk factors for GDM to the risk of GDM, finding that circulating triglycerides are the most important factor influencing GDM risk, with the highest independent contribution to GDM, highlighting the importance of focusing on lowering triglycerides as a key risk factor for GDM.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Biochemistry & Molecular Biology
Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon
Summary: The aim of this study was to determine the association of metabolic syndrome (MetS) with kidney cancer and the impact of age and gender on such an association. The study used the Korean National Health Insurance Service database to follow up 9,932,670 subjects who had check-ups in 2009 until the diagnosis of kidney cancer or death or until 2019. The results showed that kidney cancer was significantly associated with MetS, with a higher association in younger age groups and higher associations with obesity and central obesity in younger aged male population.
Article
Urology & Nephrology
Stefano Ciardullo, Cinzia Ballabeni, Roberto Trevisan, Gianluca Perseghin
Summary: This study suggests that metabolic syndrome, rather than obesity, is associated with kidney damage, and that patients with metabolic syndrome but without obesity may not have an increased risk of kidney disease.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
F. Fazzini, C. Lamina, A. Raftopoulou, A. Koller, C. Fuchsberger, C. Pattaro, F. M. Del Greco, P. Doettelmayer, L. Fendt, J. Fritz, H. Meiselbach, S. Schoenherr, L. Forer, H. Weissensteiner, P. P. Pramstaller, K. -U. Eckardt, A. A. Hicks, F. Kronenberg
Summary: The study found a significant correlation between mitochondrial DNA copy number (mtDNA-CN) and most metabolic syndrome parameters, with an inverse association between mtDNA-CN and the risk of metabolic syndrome and type 2 diabetes. The association of mtDNA-CN with type 2 diabetes is mainly mediated by obesity parameters such as waist circumference, body mass index, and triglycerides.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tong Liu, Zheng Wu, Jinghua Liu, Yun Lv, Wenzheng Li
Summary: Metabolic syndrome is associated with coronary collateralization in patients with chronic total occlusion, with body mass index posing a greater risk. Scoring systems should be further explored for potential use in this population.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Seyedeh Melika Fanaei, Ladan Mehran, Atieh Amouzegar, Safdar Masoumi, Atefeh Amouzegar, Freidoun Azizi
Summary: This study found a significant association between metabolic syndrome and the development of chronic kidney disease after 18 years of follow-up. Hypertension, diabetes, and age were strong indicators of chronic kidney disease incidence, while abdominal obesity and low-density lipoprotein were not associated with the incidence of chronic kidney disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Monika Drozdz, Anna Moczulska, Andrzej Rudzinski, Dorota Drozdz
Summary: This study aimed to identify the most significant risk factors of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD). The results showed that metabolic syndrome, hypertension, and CKD stage were the most important risk factors for LVH.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Wenzhen Li, Wenyu Ruan, Guilin Yi, Zhenlong Chen, Dongming Wang
Summary: There is an association between noise exposure and the risk of metabolic syndrome, with occupational noise exposure potentially leading to a higher risk. Further large-scale prospective studies in diverse populations are needed to confirm the results and elucidate the underlying mechanisms.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Public, Environmental & Occupational Health
Suosu Wei, Jian Song, Yujie Xie, Junzhang Huang, Jianrong Yang
Summary: This longitudinal cohort study aimed to investigate the association between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). The study found that MAFLD is an important risk factor for the development of new incidents of CKD, especially in men and individuals with combined dyslipidemia.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Endocrinology & Metabolism
Hua Xiao, Xiaofei Shao, Peichun Gao, Hequn Zou, Xinzhou Zhang
Summary: This study aimed to investigate the correlation between metabolic syndrome components and chronic kidney disease (CKD) in a community population aged 40 years and older in Southern China. The findings showed that metabolic syndrome and its components were independently associated with CKD, and the correlation remained significant in non-diabetic and non-obese subjects. Therefore, targeted screening and intervention tests in people aged 40 and over are necessary.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Victor M. Baiao, Vinicius A. Cunha, Marvery P. Duarte, Francini P. Andrade, Aparecido P. Ferreira, Otavio T. Nobrega, Joao L. Viana, Heitor S. Ribeiro
Summary: Individuals with chronic kidney disease (CKD) show systemic inflammation. Exercise interventions significantly reduce levels of inflammatory markers and increase levels of IL-10 in individuals with CKD. Resistance interventions have greater anti-inflammatory effects compared to aerobic interventions. Combined exercise interventions do not lead to significant changes in inflammatory markers.
Article
Environmental Sciences
Eisa Nazar, Hossein Baghishani, Hassan Doosti, Vahid Ghavami, Ehsan Aryan, Mahshid Nasehi, Saeid Sharafi, Habibollah Esmaily, Jamshid Yazdani Charati
Summary: This study aimed to examine the spatial variations of duration to cure and its associated factors in Iran. The results showed that factors such as gender, altitude, bacilli density, delayed diagnosis, nationality, and location significantly influenced the duration to cure, while pretreatment weight was associated with shorter duration to cure. The spatial log-logistic model with convolution prior demonstrated better performance in analyzing the duration to cure of PTB patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, Research & Experimental
Faeze Keihanian, Mohsen Moohebati, Amin Saeidinia, Seyed Ahmad Mohajeri, Saeid Madaeni
Summary: This study evaluated the effects of ten herbals on chronic heart failure (CHF) treatment and found that Allium sativum, Peganum harmala, and Berberis vulgaris showed significant improvement in cardiac function without toxic effects on renal and liver tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Marzieh Ghalandari, Khadijeh Jamialahmadi, Maryam Mardan Nik, Maryam Pirhoushiaran, Seyed Reza Mirhafez, Hassan Rooki, Amir Avan, Hamideh Ghazizadeh, Mohsen Moohebati, Mahdi Nohtani, Hooshang Zaimkohan, Gordon A. Ferns, Alireza Pasdar, Majid Ghayour-Mobarhan
Summary: The study found a significant association between IL-10 -592 C > A variant frequency and CAD, with individuals carrying the AA genotype having a higher risk of CAD. However, the results of the meta-analysis did not show a significant association between IL-10 -592 C > A and CAD in dominant and recessive genetic models.
Article
Cardiac & Cardiovascular Systems
Sara Shoeibi, Elahe Mahdipour, Shabnam Mohammadi, Mohsen Moohebati, Majid Ghayour-Mobarhan
Summary: Transplantation of EPCs overexpressing DDAH2 may enhance the repair of injured endothelium by reducing inflammation and restoring endothelial function, making it a potentially valuable tool for the treatment of atherosclerosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Mojtaba Davoudi, Fateme Barjasteh-Askari, Mohammad Sarmadi, Mohammad Ghorbani, Mehdi Yaseri, Edris Bazrafshan, Amir Hossein Mahvi, Mohsen Moohebati
Summary: The systematic review and meta-analysis indicate that populations exposed to high-fluoride drinking water have significantly higher systolic and diastolic blood pressure, as well as an increased prevalence of essential hypertension. Further research is needed to draw firm conclusions on the adverse effects of excess fluoride intake on the cardiovascular system at an individual level.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Hassan Mirshafiei, Susan Darroudi, Majid Ghayour-Mobarhan, Habibollah Esmaeili, Mina AkbariRad, Mohsen Mouhebati, Gordon A. Ferns
Summary: The TyG index and TG/HDL-C are important risk markers for insulin resistance and cardiovascular diseases. Higher levels of TyG index and TG/HDL-C are associated with increased risk of ACS and cardiac death. TyG index and TG/HDL-C may serve as important biomarkers for predicting CVD outcomes and progression.
Article
Immunology
Maryam Shayani Rad, Mohsen Moohebati, Shahab MohammadEbrahimi, Vahideh Sadat Motamedshariaty, Seyed Ahmad Mohajeri
Summary: The present study evaluated the safety and effects of celery seed extract on hypertensive patients. The results showed that celery seed extract was safe and led to a reduction in blood pressure, fasting blood sugar, and lipid profile values, as well as improvements in kidney and liver functions. However, larger randomized trials are needed to confirm these findings.
INFLAMMOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sara Saffar Soflaei, Maryam Saberi-Karimian, Mojtaba Baktashian, Mohammad Tajfard, Hedieh Alimi, Maryam Tayefi, Mohsen Moohebati, Mahmoud Ebrahimi, Negin Kosari, Mashallah Dehghani, Habibollah Esmaily, Seyed Mohammad Hashemi, Gordon A. Ferns, Mansoor Salehi, Alireza Pasdar, Majid Ghayour-Mobarhan
Summary: This study found that the levels of pro-inflammatory and anti-inflammatory cytokines and growth factors were higher in patients with coronary artery disease (CAD) 12 months after stent implantation. However, the level of high-sensitive C-reactive protein (hs-CRP) decreased in these patients, suggesting that drug treatment may play a positive role in attenuating inflammation in CAD patients.
Article
Immunology
Maryam Shayani Rad, Mohsen Moohebati, Seyed Ahmad Mohajeri
Summary: This study investigated the effects of celery seed extract as a supplement on anxiety and depression in hypertensive patients. The results showed that celery can significantly reduce symptoms of anxiety and depression, as well as lower blood pressure.
INFLAMMOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Susan Darroudi, Sara Saffar Soflaee, Zeinab Sadat Hosseini, Maryam Safari Farmad, Hassan Mirshafiei, Mohammad Sobhan Sheikh Andalibi, Mostafa Eslamiyeh, Ghazaleh Donyadideh, Reihaneh Aryan, Mansoureh Sadat Ekhteraee Toosi, Nasrin Talkhi, Habibollah Esmaily, Sara Samadi, Amir Hooshang Mohammadpour, Mina Akbari Rad, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mohsen Moohebati
Summary: This study investigated the association between visceral adiposity index (VAI) and lipid accumulation product (LAP) with cardiovascular events. The results showed a significant association in the normal weight and overweight groups, but not in the obese group.
CLINICAL NUTRITION ESPEN
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Sadegh Khorrami, Fatemeh Sadabadi, Alireza Pasdar, Hamide Safarian-Bana, Forouzan Amerizadeh, Habibollah Esmaeily, Mohsen Moohebati, Alireza Heidari-Bakavoli, Gordon Ferns, Majid Ghayour-Mobarhan, Amir Avan
Summary: This study investigated the association between the rs599839 polymorphism of the PSRC1 gene and cardiovascular disease outcomes in the MASHAD cohort. The results showed that individuals with the GA/GG genotypes had a higher risk of cardiovascular diseases.
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Correction
Endocrinology & Metabolism
Hosein Sheibani, Habibollah Esmaeili, Maryam Tayefi, Maryam Saberi-Karimian, Susan Darroudi, Mohsen Mouhebati, Mohmoud Reza Azarpazhooh, Ghasemali Divbands, Gordon A. Ferns, Mohammad Safarian, Majid Ghayour-Mobarhan
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Clinical Neurology
Hamideh Ghazizadeh, Naser Mobarra, Habibollah Esmaily, Seyed Mohammad Reza Seyedi, Amin Amiri, Fariborz Rezaeitalab, Naghmeh Mokhber, Mohsen Moohebati, Mahmoud Ebrahimi, Mohammad Tayebi, Negin Behboodi, Maryam Mohammadi-Bajgiran, Samineh Hashemi, Gordon A. Ferns, Saverio Stranges, Majid Ghayour-Mobarhan, Mahmoud Reza Azarpazhooh
Article
Biochemistry & Molecular Biology
Fatemeh Sadabadi, Aida Gholoobi, Alireza Heidari-Bakavol, Mohsen Mouhebati, Ali Javandoost, Zahra Asadi, Maryam Saberi-Karimian, Susan Darroudi, Mohammad Sadegh Khorrami Mohebbseraj, Farzad Rahmani, Najmeh Malekzadeh Gonabadi, Fatemehalsadat Jafari Sheshtamad, Sara Samadi, Afsane Bahrami, Gordon Ferns, Majid Ghayour-Mobarhan, Habibollah Esmaeili
REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Farnoush Kermanshahi, Hamideh Ghazizadeh, Nasih Abdulla Hussein, Forouzan Amerizadeh, Sara Samadi, Maryam Tayefi, Atiyeh Kamel Khodabandeh, Mohsen Moohebati, Mahmoud Ebrahimi, Habibollah Esmaily, Reza Sahebi, Rahim Abdulkarimi, Seyed Ali Reza Mousavi, Gordon A. Ferns, Amir Avan, Majid Ghayour Mobarhan
CELLULAR AND MOLECULAR BIOLOGY
(2020)