The mathematical limits of genetic prediction for complex chronic disease

Rethinking Our Public Health Genetics Research Paradigm

(2013) Abdulrahman M. El-Sayed et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Investigations of Gene–Disease Associations

(2013) Hao Luo et al.   EPIDEMIOLOGY

Twins and the mystery of missing heritability: the contribution of gene-environment interactions

(2013) J. Kaprio   JOURNAL OF INTERNAL MEDICINE

Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies

(2013) Nilanjan Chatterjee et al.   NATURE GENETICS

Pitfalls of predicting complex traits from SNPs

(2013) Naomi R. Wray et al.   NATURE REVIEWS GENETICS

A Population Approach to Precision Medicine

(2012) Muin J. Khoury et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Direct-to-Consumer Personal Genome Testing and Cancer Risk Prediction

(2012) Cecelia A. Bellcross et al.   CANCER JOURNAL

Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing

(2012) Frank S Ong et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight

(2012) Jessica Tyrrell et al.   HUMAN MOLECULAR GENETICS

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

A mega-analysis of genome-wide association studies for major depressive disorder

(2012)   MOLECULAR PSYCHIATRY

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

Recent advances in the genetic epidemiology and molecular genetics of substance use disorders

(2012) Kenneth S Kendler et al.   NATURE NEUROSCIENCE

A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory

(2012) Leroy Hood et al.   New Biotechnology

Why personalized medicine will fail if we stay the course

(2012) Edward Ramos et al.   Personalized Medicine

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry

(2011) Laramie E. Duncan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

(2011) Leah E. Mechanic et al.   GENETIC EPIDEMIOLOGY

Epidemiology, epigenetics and the ‘Gloomy Prospect’: embracing randomness in population health research and practice

(2011) George Davey Smith   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health

(2010) George Davey Smith   Genes and Nutrition

Size of the direct-to-consumer genomic testing market

(2010) Caroline F Wright et al.   GENETICS IN MEDICINE

Gene–environment-wide association studies: emerging approaches

(2010) Duncan Thomas   NATURE REVIEWS GENETICS

The Path to Personalized Medicine

(2010) Margaret A. Hamburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene–environment interactions in Leber hereditary optic neuropathy

(2009) Matthew Anthony Kirkman et al.   BRAIN

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Invited Commentary: From Genome-Wide Association Studies to Gene-Environment-Wide Interaction Studies--Challenges and Opportunities

(2008) M. J. Khoury et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Genome-based prediction of common diseases: advances and prospects

(2008) A. C. J.W. Janssens et al.   HUMAN MOLECULAR GENETICS

Misdirected precaution

(2008) Barbara Prainsack et al.   NATURE

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

(2008) Lina Chen et al.   PLOS MEDICINE