☆ 4.5 Article

Synthesis of heparan sulfate tetrasaccharide as a substrate for human heparanase

CARBOHYDRATE RESEARCH (2012)

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Journal

CARBOHYDRATE RESEARCH
Volume 353, Issue -, Pages 13-21

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2012.03.014

Keywords

Heparan sulfate; Oligosaccharide; Heparanase; Glycosaminoglycan

Categories

Biochemistry & Molecular Biology Chemistry, Applied Chemistry, Organic

Funding

  1. MEXT, Japan [20510200]
  2. Daiwa Securities Science Foundation
  3. Grants-in-Aid for Scientific Research [20510200] Funding Source: KAKEN

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Regiospecifically sulfated heparan sulfate tetrasaccharide, GlcA beta-GlcN(NS6S)alpha-GlcA beta-GlcN(NS6S)alpha was first synthesized as an octyl glycoside. Total synthesis was achieved effectively by coupling the corresponding disaccharide units in short steps. (C) 2012 Elsevier Ltd. All rights reserved.

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