Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 11, Pages 1270-1275Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.05.017
Keywords
Synthesis; Ribavirin hydrazone; Biological evaluation; A549 cells
Funding
- Natural Science Foundation of Shandong Province [Z20081310]
- Science and Technology Developmental Project of Shandong Province [2008GG1 0002034]
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A series of novel ribavirin hydrazone derivatives were synthesized by the reaction of ribavirin hydrazone with benzaldehyde or acetophenone derivatives. The structures of the compounds were determined by IR, H-1 NMR, and HRESIMS. Preliminary biological evaluation showed that one compound (7h) inhibits the growth of A549 cells at 20 mu M. (C) 2009 Elsevier Ltd. All rights reserved.
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