Journal
CARBOHYDRATE RESEARCH
Volume 344, Issue 15, Pages 2093-2095Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2009.06.020
Keywords
D-Mannoheptulose; Oxidation; Potassium permanganate; Olefinated sugar; 2-Hydroxyoxirane
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An efficient three-step synthesis of D-mannoheptulose was successfully accomplished from 2,3,4,5,6-penta-O-benzyl-D-mannose. First, an olefinated sugar was prepared from 2,3,4,5,6-penta-O-benzyl-D-mannose via a Wittig reaction. Second, the key step, a 2-hydroxyoxirane product was unexpectedly obtained by oxidation of the olefinated sugar with potassium permanganate in aqueous acetone. Finally D-mannoheptulose was synthesized through debenzylation and hydrolysis in an overall yield of 39%. (C) 2009 Published by Elsevier Ltd.
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