Journal
CARBOHYDRATE RESEARCH
Volume 343, Issue 14, Pages 2406-2410Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2008.06.022
Keywords
heparin; desulfated heparin; cell proliferation
Funding
- National Institute of Health [HL 039150, HL 62244, GM 38060]
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Heparin inhibits the growth of several cell types in vitro, including bovine pulmonary artery smooth muscle cells (BPASMCs). To understand more about the heparin structure required for endogenous activity, chemically modified derivatives of native heparin and glycol-split heparin, namely, 2-O-desulfonated iduronic/glucuronic acid residues in heparin, and 2-O-desulfonated iduronic residues in glycol-split heparin were prepared. These were assayed for their anti proliferative potency on cultured BPASMCs. All of the 2-O-desulfonated heparin derivatives had significantly decreased less antiproliferative activity on BPASMCs. These results suggest that the 2-O-sulfo group of iduronic acid residues in heparin's major sequence is essential for the antiproliferative properties of heparin. The size of heparin does not affect the growth-inhibitory properties of heparin on BPASMCs at the three dose levels examined. (C) 2008 Elsevier Ltd. All rights reserved.
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