Article
Chemistry, Applied
Xiangzhou Yi, Shuxin Gao, Xia Gao, Xuan Zhang, Guanghua Xia, Zhongyuan Liu, Haohao Shi, Xuanri Shen
Summary: This study investigated the mechanism by which tilapia head glycolipids improve the stability of liposomes. The results showed that the head groups of glycolipids and liposomes have a strong interaction, mainly through hydrogen bonds, promoting the formation of microstructure domains. Additionally, glycolipids caused the rearrangement of the bilayer structure of liposomes, resulting in an increase in phase transition temperature, tight arrangement of membrane molecules, and increase in membrane thickness. The formation of microstructure domains helped prevent the disruption of liposome membrane structure during storage and heating. Therefore, glycolipid modification can improve the stability of liposomes and provide new insights for the development of high-stability liposomes.
Review
Pharmacology & Pharmacy
Qin Shu, Hanghang Lou, Tianyu Wei, Xiayu Liu, Qihe Chen
Summary: Glycolipid biosurfactants are natural amphiphiles that have shown potential in combating microbial infections and preventing hospital infections, making them valuable in medical therapy for disease treatment and infection prevention.
Review
Biochemistry & Molecular Biology
Leila Mousavifar, Shuay Abdullayev, Rene Roy
Summary: Researchers have made systematic progress in the design of synthetic glycolipid analogs by combining dendrimer chemistry with neoglycolipid syntheses, creating novel glycoarchitectures that eliminate the need for additional lipids to enhance stability.
Review
Chemistry, Multidisciplinary
Jan Kejzar, Ilja Gasan Osojnik Crnivec, Natasa Poklar Ulrih
Summary: Archaeosomes, made from archaeal lipids, possess remarkable thermostability, resistance to enzymatic degradation, long-term stability, and immunomodulatory properties. This review focuses on the physicochemical properties and stability of total polar lipids from Aeropyrum pernix K1, specifically glycerol ether lipids with isoprenoid groups attached to glycerol via ether linkages. The effects of temperature and pH on the stability, structure, fluidity, and permeability of pure C-25,C-25 archaeosomes were examined using various techniques. The potential use of archaeal lipids as a targeted drug delivery system is also discussed.
Review
Chemistry, Medicinal
Mohamed Ahmed Attia, Ebtessam Ahmed Essa, Toka Tarek Elebyary, Ahmed Mostafa Faheem, Amal Ali Elkordy
Summary: Vaccination is the most effective means of preventing infectious diseases, and advancements in biotechnology and nanoparticles have enabled successful vaccine development. Liposomes, as a versatile carrier for vaccines, have shown great potential in delivering antigens and eliciting desired immune responses during the ongoing pandemic of COVID-19.
Article
Chemistry, Multidisciplinary
Atsushi Shimoyama, Flaviana Di Lorenzo, Haruki Yamaura, Keisuke Mizote, Angelo Palmigiano, Molly D. Pither, Immacolata Speciale, Tomoya Uto, Seiji Masui, Luisa Sturiale, Domenico Garozzo, Koji Hosomi, Naoko Shibata, Kazuya Kabayama, Yukari Fujimoto, Alba Silipo, Jun Kunisawa, Hiroshi Kiyono, Antonio Molinaro, Koichi Fukase
Summary: The study characterized the structure of lipooligosaccharide (LOS) and lipopolysaccharide (LPS) from Alcaligenes faecalis. The hexaacylated A. faecalis lipid A was found to have moderate agonistic activity towards TLR4-mediated signaling and the ability to induce interleukin-6 release, making it a promising vaccine adjuvant candidate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Immunology
Sivakumar S. Moni, Siddig Ibrahim Abdelwahab, Aamena Jabeen, Mohamed Eltaib Elmobark, Duaa Aqaili, Gassem Ghoal, Bassem Oraibi, Abdulla Mohammed Farasani, Ahmed Ali Jerah, Mahdi Mohammed A. Alnajai, Abdul Majeed Hamad Mohammad Alowayni
Summary: This review provides a thorough analysis of the advances in adjuvant research and explores the evolution and effects of various adjuvants. Alum, as the pioneer, laid the foundation for further research and innovation. The transition from traditional alum-based adjuvants to nano formulations reflects the dynamism and potential of vaccine research. Innovations in adjuvant research, particularly the development of nano formulations, hold great promise for improving vaccine efficacy and safety.
Article
Chemistry, Multidisciplinary
Mira Holzheimer, Jaap S. Sinninghe Damste, Stefan Schouten, Remco W. A. Havenith, Ana V. Cunha, Adriaan J. Minnaard
Summary: Crenarchaeol is a glycerol dialkyl glycerol tetraether lipid exclusively produced in Archaea, with a highly complex structure that is considered iconic in organic geochemistry. Researchers have successfully completed the first total synthesis of the proposed structure of crenarchaeol, leading to a revised understanding of its chemical composition.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Wenli Wang, Yuxin Li, Ye He, Xing Jiang, Ying Yi, Xihan Zhang, Shiyu Zhang, Guangtong Chen, Min Yang, Jia-Lie Luo, Boyi Fan
Summary: This review summarizes the various efforts made in the last decade towards the synthesis of resin glycosides. It highlights the importance of their structural complexity and biological activities, as well as the insights they provide for the synthesis of glycoside compounds.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ruben L. H. Andringa, Niels A. W. Kok, Arnold J. M. Driessen, Adriaan J. Minnaard
Summary: Ir-catalyzed asymmetric alkene hydrogenation combined with an established C-13-NMR method can effectively synthesize saturated isoprenoids and mycoketides, significantly improving synthetic efficiency.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Kohtaro Hirao, Immacolata Speciale, Anna Notaro, Yoshiyuki Manabe, Yoshiaki Teramoto, Takaaki Sato, Haruyuki Atomi, Antonio Molinaro, Yoshihiro Ueda, Cristina De Castro, Koichi Fukase
Summary: This study describes the isolation, structural determination, and chemical synthesis of the N-glycan from the hyperthermophilic archaeon Thermococcus kodakarensis, revealing a unique structure including myo-inositol not found in previously characterized N-glycans. The synthesis of this glycan was successfully achieved through diastereoselective phosphorylation and phosphodiester construction by S(N)2 coupling. This research is expected to provide insights into the primitive function of glycan modification at the molecular level by considering the early divergence of hyperthermophilic organisms in evolution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Dennis Litty, Volker Mueller
Summary: The study found that the ATP synthase in hyperthermophilic archaea has an unusual subunit c, which is predicted to prevent ATP synthesis. However, it was observed that this enzyme can still synthesize ATP under physiological conditions. Additionally, the research revealed an intermediate state in the transition from ATP hydrolases to ATP synthases, providing insight into the bioenergetic adaptation of microbial growth near thermodynamic equilibrium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Michael J. Zeiler, Gina M. Connors, Greg M. Durling, Allen G. Oliver, Lewis Marquez, Roberta J. Melander, Cassandra L. Quave, Christian Melander
Summary: Antibiotic resistance has become a serious problem, requiring new approaches to combat infections caused by resistant bacteria. One such approach is the development of small molecules called adjuvants, which enhance the activity of conventional antibiotics. This study discovered a natural product called (-)-LZ-2112 that synergizes with oxacillin to fight against methicillin-resistant Staphylococcus aureus. Further research identified key structural elements of (-)-LZ-2112 and suggested the possibility of simplifying its structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Catalina Ionescu, Fidan Huseynova, Veronique Barragan-Montero
Summary: This paper describes the synthesis of two glycolipids containing a mannosyl residue and the comparative discussion of two synthetic routes. These glycolipids serve as material for the preparation of liposomes.
CHEMISTRY AND PHYSICS OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Ho-Ting-Venice Iu, Pak-Ming Fong, Hin-Cheung-Bill Yam, Peng Gao, Bingpeng Yan, Pok-Man Lai, Victor-Yat-Man Tang, Ka-Ho Li, Chi-Wang Ma, King-Hei-Kenneth Ng, Kong-Hung Sze, Dan Yang, Julian Davies, Richard-Yi-Tsun Kao
Summary: Antibiotic tolerance poses a threat as it allows bacteria to survive antibiotic treatment, leading to persistent and difficult-to-treat infections. This can result in antibiotic treatment failure and impose a burden on the healthcare system. The study identified a small molecule compound, SA-558, that effectively targets antibiotic-tolerant Staphylococcus aureus and reduces their population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)