Journal
CARBOHYDRATE RESEARCH
Volume 343, Issue 4, Pages 587-595Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2007.12.020
Keywords
heparan sulfate; disaccharide; imprinting; molecular recognition
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A heparan sulfate disaccharide analog was synthesized by a multistep route. This synthesis was designed in such a way that one intermediate could be selectively deprotected to provide versatility during both synthesis and homologation of heparan sulfate related polysaccharides. Non-covalent imprinted polymers were prepared by using the synthesized disaccharide as a template and a primary amine functionalized acrylate as the key functional monomer suitable for specific sulfated sugar recognition. The binding of related sugars to the imprinted and non-imprinted polymers and the binding of template to the chemically modified polymers have been also investigated. (c) 2007 Elsevier Ltd. All rights reserved.
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