Journal
CARBOHYDRATE POLYMERS
Volume 103, Issue -, Pages 520-527Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.12.080
Keywords
Ganoderma atrum polysaccharide; Aorta; Vascular endothelium; Vasorelaxation
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Funding
- National Natural Science Foundation of China [31071532]
- National Key Technology R & D Program of China [2012BAD33B06]
- Program for New Century Excellent Talents in University [NCET-12-0749]
- Project of Science and Technology of Jiangxi Provincial Education Department [KJLD13004]
- Research Project of State Key Laboratory of Food Science and Technology [SKLF-ZZA-201301]
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A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway. (C) 2014 Elsevier Ltd. All rights reserved.
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