Journal
CARBOHYDRATE POLYMERS
Volume 107, Issue -, Pages 247-254Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.02.071
Keywords
Costaria costata; Fucoidan; Structural characterisation; Liver injury
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Funding
- Agricultural Public Welfare Scientific Research Project of the Ministry of Agriculture [200903030]
- Agricultural Science and Technology Achievement Transformation Funds of the Ministry of Science and Technology of the People's Republic of China [2008GB2B000061]
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Fucoidan is a well-known natural product that is commonly found in brown algae and shows a variety of activities, including immunomodulation, antioxidation, and the combat of carcinogens. The fucoidan fractions of Costaria costata, a brown algae introduced from Japan and cultured in northern China, were studied. The fucoidan fractions were extracted, separated, and purified using a combinatorial procedure consisting of enzymolysis, ethanol precipitation, and DEAE and size-exclusion chromatographies. The fundamental characteristics of the four enriched fucoidan fractions (F1-F4), such as their sulphate content and monosaccharide composition, were investigated. FTIR and NMR spectroscopy were employed to further elucidate the structural features of the four fractions. It was found that the F1-F4 fractions all showed oxidative activity against hydroxyl radicals. The bioactive effects of the fucoidan fractions on CCl4-induced liver injury suggest their potential use as ingredients for functional foods or pharmaceuticals. (C) 2014 Elsevier Ltd. All rights reserved.
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