Journal
CARBOHYDRATE POLYMERS
Volume 98, Issue 1, Pages 711-720Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.06.013
Keywords
Microspheres; Starch; Curcumin; Oral drug delivery system; Antitumor activity
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Curcumin (CUR) has been proved to be highly cytotoxic against different tumor cell lines. However, its poor solubility in aqueous medium and fast degradation in physiological pH are the common drawbacks preventing its efficient practical use. Herein, we report the development of original microspheres based on the biopolymer starch crosslinked with N,N-methylenebisacrylamide (MBA) to be applied as an efficient delivering system for CUR. The starch-based microspheres showed high loading efficiency even in loading solution with different CUR concentrations. In vitro release assays data showed that the CUR release is governed by anomalous transport (n = 0.73) and it is pH-dependent. Cytotoxicity assays showed that starch microspheres could improve the cytotoxicity of CUR toward Caco-2 and HCT-116 tumor cell lines up to 40 times than that found for pure CUR. This behavior was attributed to the slowly and sustained release of CUR from the microspheres. (C) 2013 Elsevier Ltd. All rights reserved.
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