Journal
CARBOHYDRATE POLYMERS
Volume 97, Issue 2, Pages 753-757Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.05.064
Keywords
Anti-fouling; Dextran; Catechol; Protein adsorption; Titanium dioxide
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Funding
- Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A103017]
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Surface modification of inorganic materials to prevent non-specific protein adsorption is critically important for developing a biocompatible materials' platform for medical implantation, diagnostics, and therapeutics. Here we report mussel-inspired chemical modification of dextran for anti-fouling coatings of metal oxide. Catechols are conjugated to dextran via a carbamate ester linkage, producing catechol-grafted dextran with a grafting density of 7.3 mol.%. Titanium dioxide (TiO2) is coated with the catechol-grafted dextran, and the anti-fouling effect of dextran coatings is examined by using the adsorption of human serum albumin. The mussel-inspired dextran coatings show excellent resistance to non-specific protein adsorption: the adsorption equilibrium constant (K) is 0.69 Lg(-1) for dextran-coated TiO2 while that for pristine TiO2 surface is 3.53 Lg(-1). This study suggests that catechol-grafted dextran is a promising material for effective anti-fouling coatings of implantable inorganic materials. (C) 2013 Elsevier Ltd. All rights reserved.
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