Journal
CARBOHYDRATE POLYMERS
Volume 94, Issue 1, Pages 444-448Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2013.01.061
Keywords
Self-assembly; PH-responsive; Hyaluronic acid; POSS; Organic/inorganic hybrid material
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Funding
- National Natural Science Foundation of China [81171459, 31270021]
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We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors. (C) 2013 Elsevier Ltd. All rights reserved.
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