Journal
CARBOHYDRATE POLYMERS
Volume 84, Issue 1, Pages 624-630Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2010.12.038
Keywords
Chitosan-poly(epsilon-caprolactone); Fibrous membrane; Ketoprofen release; Kinetics
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Funding
- National Natural Science Foundation of China [30970741]
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Chitosan-poly(epsilon-caprolactone) was fabricated into drug-enclosed fibrous membranes by loading with ketoprofen and using a wet-spinning method. The optimized chitosan-poly(epsilon-caprolactone) fibrous membranes with poly(epsilon-caprolactone) proportions changing from about 20 to 40 wt% showed notably enhanced tensile strength in wet state as compared to pure chitosan fibrous membranes. Some membranes loaded with an initial amount of around 8 wt% ketoprofen were capable of maintaining sustained releases of ketoprofen for a period of time longer than 50 h without significant initial burst release, and the corresponding release profiles could be effectively controlled by regulating the composition and diameters of the filaments. Kinetic analysis indicated that ketoprofen-release patterns from selected membranes were well fitted with Higuchi model and showed biphasic characteristics with different release-rate constants depending on the parameters of the membranes; and ketoprofen-releases were administrated by anomalous mechanisms involved both initial swelling and follow-up diffusion. (C) 2010 Elsevier Ltd. All rights reserved.
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