Journal
CARBOHYDRATE POLYMERS
Volume 78, Issue 1, Pages 107-111Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2009.04.035
Keywords
Chitosan; Nanocomplexes; Drug release; Bioinspired mineralization; Bone tissue engineering
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Funding
- National Natural Science Foundation of China [20504018]
- National High Technology Research and Development Program of China (863 Program) [2007AA09Z440]
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Chitosan-based nanocomplexes with various forms were prepared by ionically crosslinking with tripolyphosphate (TPP) in different acidic media under mild conditions. It was found that the self-assembly and ionic interactions of chitosan and TPP were greatly affected by reaction media, and chitosan-based nanofibers could be obtained in adipic acid medium while nanoparticles were formed in acetic acid medium. Using bovine serum albumin (BSA) as a macromolecular model-drug, in vitro drug release studies indicated that chitosan-based nanofibers and narroparticles exhibited a similar prolonged release profile. In addition, the bioinspired mineralization of both chitosan-based nanofibers and nanoparticles was carried out by soaking them in synthetic body fluids (SBF). Transmission electron microscopy (TEM) and X-ray Diffraction (XRD) results indicated that chitosan-based nanofibers have better inductivity for nano-hydroxyapatite formation than chitosan-based nanoparticles. The results suggested that biomimetic chitosan-based nanofibers; with controlled release capacity of bioactive factors may be of use in bone tissue engineering for enhancing the bioactivity and bone inductivity. (C) 2009 Elsevier Ltd. All rights reserved.
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