Editorial Material
Oncology
Francisco Hermida-Prado, Rinath Jeselsohn
Summary: ESR1 ligand-binding mutations, the most common genetic mechanism of acquired resistance to endocrine treatment, lead to constitutive ligand-independent activity, emerging under the selective pressure of aromatase inhibitors. New models of these mutations have been generated using CRISPR technology, shedding light on their functional consequences.
Review
Cell Biology
Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Summary: Oncolytic viruses, either natural or genetically engineered, can replicate in tumor cells and inhibit tumor growth, making them an effective anticancer strategy. Their multifunctional characteristics suggest promising application prospects in cancer therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Changwon Wang, Chungkeun Lee, Hangsik Shin
Summary: As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing. However, the lack of consensus on a definition, insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity have made the use of DTx as a general medical component ambiguous. This study investigates definitions, clinical trials, commercial products, and regulatory status related to DTx and suggests the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on commercialization characteristics.
NPJ DIGITAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Zita Szentkereszty-Kovacs, Krisztian Gaspar, Andrea Szegedi, Lajos Kemeny, Dora Kovacs, Daniel Torocsik
Summary: This review discusses the impact of alcohol on psoriatic patients, linking clinical observations with molecular background and providing insights on how this knowledge could influence treatment selection and patient management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Suzana Tesanovic, Peter W. Krenn, Fritz Aberger
Summary: Despite advances in understanding the genetic alterations and biology of acute myeloid leukemia (AML), the translation into clinical treatment approaches is still in its early stages. A major challenge in AML therapy is the high relapse rates, largely due to the presence of treatment-resistant leukemic stem cells (LSCs). The Hedgehog (HH) signaling pathway has emerged as a therapeutic target in AML, as it plays a crucial role in the development and progression of cancer stem cell driven tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fang, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs) are emerging catalytic nanomaterials with enzyme-like activities, which hold great promise in medical applications. This article presents the recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Article
Hematology
Sangeetha Venugopal, Justin Watts
Summary: The discovery of IDH1 mutations in AML and the success of molecularly targeted therapies led to the development of IDH1mut inhibitors. Olutasidenib, a novel IDH1mut inhibitor, showed promising results in treating patients with R/R IDH1mut AML, including durable remission rates and transfusion independence. This review examines the development and positioning of olutasidenib in the treatment of IDH1mut AML.
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fan, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs), a new type of catalytic nanomaterials with enzyme-mimetic activities, have gained extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recent studies have demonstrated the great potential of SANs in biological applications, including anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Review
Gastroenterology & Hepatology
Daolin Tang, Guido Kroemer, Rui Kang
Summary: The role of ferroptosis in hepatocellular carcinoma (HCC) is complex and diverse. While it can contribute to the progression of HCC, it might also be desirable to target ferroptosis in HCC cells. This review examines the mechanisms, regulation, biomarkers, and clinical implications of ferroptosis in HCC from cellular, animal, and human perspectives.
Review
Medicine, Research & Experimental
Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F. Naylor, Robert E. Nordquist, Wei R. Chen, Feifan Zhou
Summary: The combination of targeted therapy and immunotherapy is considered an ideal strategy for treating metastatic cancer, with phototherapy emerging as a promising targeted therapy that can initiate antitumor immune responses through induced immunogenic tumor cell death. The use of phototherapy in conjunction with immunoadjuvant therapy has shown to induce a systemic antitumor immune response, controlling residual tumor cells at the treatment site and distant metastases.
Article
Engineering, Biomedical
Hatice B. Bingol, Johan C. M. E. Bender, Joost A. Opsteen, Sander C. G. Leeuwenburgh
Summary: Biodegradable bone adhesives are highly sought-after biomaterials that can replace traditional metallic devices for bone fixation. However, these biomaterials must meet numerous requirements, and commercially available bone-adhesive biomaterials that fulfill all of these requirements are currently not available. This comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective, highlighting the definition, classification, and chemistry of various types of bone adhesives. The review also focuses on materials capable of gluing two pieces of bone together within a time frame of minutes to days and critically reflects on commonly employed adhesion tests and the current state-of-the-art in their preclinical and clinical applicability.
MATERIALS TODAY BIO
(2023)
Review
Psychiatry
Julian Cheron, Alban de Kerchove d'Exaerde
Summary: Drug addiction causes millions of deaths per year worldwide, but misconceptions from the general public shadow its management as a chronic disease. Drug consumers are often stigmatized, leading to addiction being viewed as an individual issue rather than a societal one.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Neurosciences
Shuo-Qi Zhang, Jun Xiao, Man Chen, Luo-Qi Zhou, Ke Shang, Chuan Qin, Dai-Shi Tian
Summary: S1P signaling plays a crucial role in the treatment of ischemic stroke by regulating immune cell migration, sustaining endothelial function, and maintaining blood-brain barrier integrity. Understanding the role of S1P signaling in stroke and the ability to finely regulate the signal pathway are essential for the success of bench-to-bedside translation in the future.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Eleonora Galli, Elena Maggio, Fulvio Pomero
Summary: Septic patients are at a high risk of thrombotic complications due to coagulation disorders. The interconnected and reciprocal influence of immune and coagulation systems, known as immunothrombosis, plays a critical role in host defense and thrombogenesis. Dysregulation of this network during sepsis can lead to pathological thrombosis.
Review
Hematology
Eline Menu, Karin Vanderkerken
Summary: This review summarizes the role of exosomes in multiple myeloma (MM), including their involvement in osteolysis, angiogenesis, immune suppression, and drug resistance. Targeting exosome secretion could potentially block these processes. The review also discusses current treatment strategies to counter these processes and explores how exosomes can be harnessed to deliver toxic payloads. Additionally, the review provides an overview of clinical studies investigating exosome cargo as potential MM biomarkers in liquid biopsies.
Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)
