Article
Geriatrics & Gerontology
Martine Extermann, Mohammed Al-Jumayli, Christine Sam, Julie A. Kish
Summary: Cancer is an age-related disease and it is becoming the leading cause of death among older people. Geriatricians frequently encounter cancer problems. Recent progress in comprehensive geriatric assessment and management has shown that it can improve outcomes in older cancer patients by reducing treatment toxicity, increasing treatment completion rates, and improving functional outcomes. Studies have also shown advancements in the treatment of GI cancers, breast cancer, Acute Myeloid Leukemia, and prostate cancer.
Article
Medicine, General & Internal
H. Levassort, M. Pepin, L. Teillet, D. Ghebriou, T. Cudennec
Summary: With an aging population and high cancer incidence among individuals over 75 years old, collaboration between oncologists and geriatricians is necessary to improve care for elderly patients. The G8 screening tool helps identify patients who would benefit from a geriatric assessment, which plays a crucial role in treatment planning and patient survival.
REVUE DE MEDECINE INTERNE
(2022)
Review
Oncology
Ding Quan Ng, Daniella Chan, Parisa Agrawal, Weian Zhao, Xiangmin Xu, Munjal Acharya, Alexandre Chan
Summary: This systematic review assessed the relationship between BDNF biomarkers and neurocognitive outcomes in cancer patients and survivors. The results suggest that BDNF is a potential monitoring biomarker and druggable target for CRCI.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Qiong Wang, Shuai Zhou, Jingya Zhang, Qing Wang, Fangfang Hou, Xiao Han, Guodong Shen, Yan Zhang
Summary: A risk assessment tool for mild cognitive impairment (MCI) was developed and validated in this study, focusing on modifiable factors and risk stratification. Nine modifiable risk factors were selected and the tool's performance was verified using cross-sectional and longitudinal datasets from a Chinese elderly cohort. The tool has significant public health implications for the primary prevention of MCI in elderly individuals in China.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Pharmacology & Pharmacy
Yuwei Hua, Yuling Zou, Mei Guan, Hsiang-Yu Yuan, Yanping Zhou, Fengshuo Liu
Summary: The purpose of this study was to develop a tool to identify elderly patients vulnerable to chemotherapy toxicity. Factors such as cancer type, physical status, chemotherapy regimen, and laboratory test results were found to be associated with severe chemotherapy-related toxicity. A predictive model was constructed to help clinicians identify vulnerable population and adjust treatment regimens accordingly.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Byung Soo Kwan, Ok Jae Lee, Hyun Jin Kim, Kwang Min Kim, Sang Goon Shim, Dae Hyeon Cho, Sung Min Kong, Jun Young Kim, Jun Ho Ji
Summary: This study compared the efficacy and safety of chemotherapy in elderly patients with unresectable pancreatic cancer. The results showed that chemotherapy improved median overall survival among elderly patients, but some patients discontinued treatment due to adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jacques A. Herzog, Craig A. Buchman, Dorina Kallogjeri, Stephanie Chen, Cameron Wick, Nedim Durakovic, Matthew A. Shew
Summary: The study examined the long-term speech and cognition outcomes in older adult cochlear implant recipients. The results showed that speech performance was significantly improved and maintained over an extended follow-up period, regardless of the preoperative cognitive status. Additionally, there was no significant difference in the rate of cognitive decline between preoperative mild cognitive impairment and normal cognition patients after cochlear implantation.
Article
Oncology
Lana Khalil, Xingyu Gao, Jeffrey M. Switchenko, Olatunji B. Alese, Mehmet Akce, Christina Wu, Maria Diab, Bassel F. El-Rayes, Walid L. Shaib
Summary: This age group-based study examines the impact of adjuvant therapy in patients older than 70 with colon cancer. The study suggests that multi-agent chemotherapy may have better survival outcomes compared to single-agent chemotherapy in this age group.
Article
Oncology
Xin Chen, Junhao Tu, Xiaolan Xu, Wen Gu, Lei Qin, Haixin Qian, Zhenyu Jia, Chuntao Ma, Yinkai Xu
Summary: This study found that adjuvant chemotherapy in elderly patients with stage III colon cancer can reduce cancer-specific mortality rate, but the benefit of chemotherapy in stage II colon cancer patients is suboptimal.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jianping Guo, Zhizhong Xiong, Shi Yin, Yue'e Wen, Longyang Jin, Caiqin Wang, Huaxian Chen, Dandong Luo, Zijian Deng, Dayin Huang, Xianzhe Li, Biying Yi, Chaobin Mao, Lei Lian
Summary: This study identified 75 years old as the optimal age cutoff for defining EGC, and found that EGC patients had significantly worse overall survival and cancer-specific survival compared to non-EGC group. Adjuvant chemotherapy was proved to be unbeneficial for stage II EGC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Marie-Rose Dwek, Stanton P. Newman, Stefano Brini, Pru Holder, Michael Machesney, David Propper, Lorna R. Rixon, Shashivadan P. Hirani, Catherine S. Hurt
Summary: This study examined the effects of chemotherapy on cognitive performance in colorectal cancer patients. The findings reveal that 45%-55% of patients showed cognitive deficits 10 months after surgery, but the impact of chemotherapy on cognitive impairment is unclear. In terms of cognitive recovery, patients who underwent surgery only showed better improvement compared to those who received chemotherapy.
Article
Integrative & Complementary Medicine
Ulku Ozdemir, Sultan Tasci
Summary: The aim of this study was to investigate the effect of acupressure on the severity and level of cancer-related fatigue in elderly patients with cancer. The results showed that there was a significant reduction in the severity and level of fatigue in the acupressure group compared to the control group. Therefore, acupressure can be recommended as a treatment for cancer-related fatigue in elderly patients.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Oncology
Alicia Duval, Christopher G. Davis, Eve-Ling Khoo, Heather Romanow, Yaadwinder Shergill, Danielle Rice, Andra M. Smith, Patricia A. Poulin, Barbara Collins
Summary: This study found that mindfulness training can alleviate subjective memory impairments in breast cancer survivors receiving chemotherapy, but has no effect on objective assessments.
Article
Multidisciplinary Sciences
Federico Nichetti, Francesca Ligorio, Giulia Montelatici, Luca Porcu, Emma Zattarin, Leonardo Provenzano, Andrea Franza, Luca Lalli, Filippo de Braud, Marco Platania
Summary: Hospitalized cancer patients are at increased risk for Thromboembolic Events (TEs). A new risk-assessment model (RAM) was developed in this population, showing good Negative Predictive Value (NPV) but poor Positive Predictive Value (PPV) for TEs. Additionally, TEs were associated with poorer overall survival (OS) in these patients.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Brenna C. McDonald
Summary: Cancer- and treatment-related cognitive dysfunction (CRCD) is a common challenge for non-central nervous system (CNS) cancer patients, with structural neuroimaging revealing reduced gray matter and white matter integrity in cancer patients compared to control groups, particularly prominent in those undergoing chemotherapy.
Article
Medicine, General & Internal
Marie Lange, Sarah Joo, Pierre-Andre Couette, Francois Le Bas, Xavier Humbert
Summary: This study assessed the mental health impact of COVID-19 on French General Practitioners, finding that up to 42% reported psychological disturbances including burnout and post-traumatic stress symptoms. Women were more likely to experience stress and burnout symptoms compared to men.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Oncology
F. Joly Lobbedez, I. Hardy-Leger, S. Lefevre Arbogast, O. Rigal, J. Le Fel, B. Pistilli, J. Petrucci, C. Levy, A. Capel, C. Coutant, F. Lerebours, L. Vanlemmens, E. Bourbouloux, I. Vaz-Luis, A-L. Martin, S. Everhard, F. Andre, C. Charles, S. Dauchy, M. Lange
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Florence Joly, Olivier Rigal, Lydia Guittet, Sophie Lefevre-Arbogast, Jean-Michel Grellard, Giulia Binarelli, Marie Lange, Chantal Rieux, Marie Fernette, Laure Tron, Francois Gernier, Romain Travers, Adeline Morel, Doriane Richard, Benedicte Griffon, Alexandra Leconte, Etienne Bastien, Florian Quilan, Louis-Ferdinand Pepin, Fabrice Jardin, Marianne Leheurteur, Benedicte Clarisse, Justine Lequesne, Audrey Faveyrial
Summary: This study assessed the occurrence of PTSD symptoms among cancer patients during the COVID-19 pandemic, finding that 21% of patients experienced PTSD symptoms and those who had adjustments in medical oncology practice were more likely to have PTSD symptoms. Women and patients experiencing adjustments were more likely to have PTSD symptoms, and PTSD symptoms were correlated with poorer quality of life, cognition, and insomnia scores.
Meeting Abstract
Oncology
Florence Joly, Sophie Lefevre-Arbogast, Olivier Rigal, Etienne Bastien, Lydia Guittet, Jean-Michel Grellard, Marie Lange, Alexandra Leconte, Florian Quilan, Romain Travers, Adeline Morel, Louis-Ferdinand Pepin, Fabrice Jardin, Marianne Leheurteur, Justine Lequesne, Benedicte Clarisse, Giulia Binarelli, Audrey Faveyrial
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Psychology, Clinical
Mylene Duivon, Benedicte Giffard, Beatrice Desgranges, Joy Perrier
Summary: Patients with non-central nervous system cancer often report cognitive complaints that are related to sleep quality, with greater complaints correlating with poorer self-reported sleep quality in most studies. However, the association between poorer neuropsychological performances and sleep complaints in these patients remains inconsistent in the literature.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Oncology
Brent J. Small, Marie Lange, Wanting Zhai, Jaeil Ahn, Tim A. Ahles, Judith E. Carroll, Harvey J. Cohen, Deena Graham, Martine Extermann, Natacha Heutte, Heather S. L. Jim, Brenna C. McDonald, Sunita K. Patel, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Xingtao Zhou, Jeanne Mandelblatt, Florence Joly
Summary: Pooled individual-level data from two large prospective studies of older breast cancer survivors showed that older women who received taxane-based chemotherapy did not experience greater declines in cognitive performance or well-being compared to women receiving other chemotherapy regimens. Despite being at greater risk for negative outcomes, treatment with taxane-based chemotherapies did not exacerbate these health consequences for older cancer survivors.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Neurosciences
Joy Perrier, Gina Joue, Beatrice Desgranges, Djelila Allouache, Christelle Levy, Sabine Noal, Jacques Dayan, Francis Eustache, Florence Joly, Armelle Viard, Benedicte Giffard
Summary: Modifications in self-representations have been observed in breast cancer patients, with changes in self-assertion and self-esteem. These changes are related to alterations in intrinsic functional brain connectivity. Resting-state functional connectivity between specific brain regions involved in self-referential processes decreases over time in breast cancer patients, which may be associated with their positive self-images and temporary adaptive strategies.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Marie Lange, Idlir Licaj, Michel Boulouard, David Garon, Estelle Richard, Jeanne Le Bas, Remi Salmon, Rheda Stroiazzo, Francois Le Bas, Xavier Humbert
Summary: This longitudinal study assesses the psychological impact of the COVID-19 outbreak on French owner community pharmacists. The results indicate that stress, posttraumatic stress, and burnout symptoms decreased during the follow-up period.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2022)
Article
Clinical Neurology
Tristan Martin, Mylene Duivon, Nicolas Bessot, Jean-Michel Grellard, George Emile, Sebastien Polvent, Lucie Raoul, Fausto Viader, Francis Eustache, Florence Joly, Benedicte Giffard, Joy Perrier
Summary: This study aimed to compare the rest-activity rhythm and sleep characteristics of breast cancer patients receiving endocrine therapy, untreated breast cancer patients, and healthy controls. The results showed that breast cancer patients had lower daytime activity, endocrine therapy patients had more sleep complaints and lower sleep efficiency.
Article
Multidisciplinary Sciences
J. Perrier, M. Duivon, P. Clochon, S. Rehel, F. Doidy, J. M. Grellard, C. Segura-Djezzar, J. Geffrelot, G. Emile, D. Allouache, C. Levy, S. Polvent, F. Viader, F. Eustache, F. Joly, B. Giffard
Summary: Sleep disturbance is common among breast cancer survivors, with differences in sleep structure compared to healthy controls, including increased awakenings, decreased Delta power during sleep deepening and recovery, increased Alpha and Beta power related to arousal during deep sleep, and decreased Theta power related to emotional regulation during dream sleep.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Marie Lange, Benedicte Clarisse, Alexandra Leconte, Kleouforo-Paul Dembele, Justine Lequesne, Celeste Nicola, Martine Dubois, Laurence Derues, Yori Gidron, Helene Castel, Florence Joly
Summary: This study aims to evaluate the impact of immunotherapy on cognitive function in cancer patients without simultaneous anti-cancer treatment and to explore its effects on quality of life. The study will assess the incidence of cognitive decline and investigate secondary endpoints such as anxiety, depression, fatigue, clinical characteristics, biological data, and neurophysiological measures.
Review
Oncology
Charlotte Sleurs, Ali Amidi, Lisa M. Wu, David Kiesl, Philipp Zimmer, Marie Lange, Anne Rogiers, Benedicte Giffard, Giulia Binarelli, Cindy Borghgraef, Sabine Deprez, Mylene Duivon, Michiel De Ruiter, Sanne Schagen, Djihane Ahmed-Lecheheb, Helene Castel, Cecilie R. Buskbjerg, Melanie Dos Santos, Florence Joly, Joy Perrier
Summary: Cancer-related cognitive impairment (CRCI) has been increasingly identified in non-CNS system cancer patients over the last two decades in Europe. Researchers in Europe have contributed to the field by developing preclinical models and exploring underlying mechanisms. New challenges need to be addressed, including data sharing, standardization of assessments, and assessing additional biomarkers and neuroimaging investigations. This consensus paper summarizes the current state of CRCI research in Europe and proposes specific actions for future intervention programs based on shared scientific expert opinion.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Marie Lange, Sophie Lefevre Arbogast, Isabelle Hardy-Leger, Olivier Rigal, Johan Le Fel, Barbara Pistilli, Jean Petrucci, Christelle Levy, Aurelie Capel, Charles Coutant, Laure Medeau, Florence Lerebours, Laurence Vanlemmens, Marine Brion, Emmanuelle Bourbouloux, Maxime Blain, Giulia Binarelli, Ines Vaz-Luis, Benedicte Giffard, Ophelie Querel, Sibille Everhard, Fabrice Andre, Cecile Charles, Sarah Dauchy, Florence Joly
Summary: Using the CANTO cohort, this study assessed cognitive functioning change after cancer treatments in a subgroup of breast cancer patients. The results showed that breast cancer patients had lower cognitive abilities before treatment and chemotherapy could lead to a decline in executive function and an increase in cognitive difficulties.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Joy Perrier, Melvin Galin, Pierre Denise, Benedicte Giffard, Gaelle Quarck
Summary: Patients with breast cancer often suffer from insomnia, which can have negative effects on their quality of life and cancer progression. Current approaches to manage insomnia in these patients only address sleep complaints and well-being, and may be difficult to implement after chemotherapy. Vestibular stimulation, however, has shown promising results in improving sleep and rest-activity rhythm, making it a suitable option for managing insomnia symptoms in breast cancer patients.
Article
Engineering, Biomedical
Emilie Hummel, Melanie Cogne, Marie Lange, Anatole Lecuyer, Florence Joly, Valerie Gouranton
Summary: This study provides an overview of sixteen vocational or ecological VR-based clinical studies among patients with cognitive impairment. The results highlight the importance of higher immersion in promoting participant engagement and transferability, which are rarely assessed in current literature. However, there is a lack of adaptivity in studies involving patients with cognitive impairments.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
