Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Oncology
Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Adrienne B. Shannon, James Sun, Karenia Landa, Kirsten M. Baecher, Christian Wood, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Tsai, Mark B. Faries, Georgia M. Beasley, Vernon Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
Summary: The study revealed that in clinically localized Merkel cell carcinoma, males, patients over 75 years old, and those with lymphovascular invasion are more likely to have false negative SLNB results. Patients with false negative SLNB experienced shorter time to nodal recurrence and significantly worse survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Danielle Brazel, Priyanka Kumar, Hung Doan, Tianyu Pan, Weining Shen, Ling Gao, Justin T. Moyers
Summary: Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with increasing incidence. This study aimed to identify actionable alterations associated with tumor mutation burden (TMB) using the OncoKB database. The findings suggest that targeted therapies may be a viable treatment option for selected MCC patients.
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Kevin L. Ma, Cimarron E. Sharon, Gabriella N. Tortorello, Nikhita J. Perry, Luke J. Keele, John N. Lukens, Giorgos C. Karakousis, John T. Miura
Summary: This retrospective cohort study analyzed data from the National Cancer Database from 2012 to 2019. The study found that there was no significant difference in survival benefits between radiation therapy and completion lymph node dissection for regional lymph node micrometastasis in Merkel cell carcinoma (MCC) patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elena Dellambra, Maria Luigia Carbone, Francesca Ricci, Francesco Ricci, Francesca Romana Di Pietro, Gaia Moretta, Sofia Verkoskaia, Elisa Feudi, Cristina M. Failla, Damiano Abeni, Luca Fania
Summary: Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine carcinoma of the skin, with increasing incidence worldwide. Treatment of advanced MCC tumors with immune checkpoint inhibitors has shown effective results, highlighting the importance of immunotherapy in managing this disease.
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Merkel cell carcinoma is an aggressive malignant skin tumor with high recurrence and low survival. Lymph nodal metastases are associated with a worse overall prognosis. Factors such as increasing age, tumor size, and truncal location are associated with higher positive lymph node rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Steffi Silling, Alexander Kreuter, Thilo Gambichler, Thomas Meyer, Eggert Stockfleth, Ulrike Wieland
Summary: Merkel cell polyomavirus (MCPyV) is a common virus on human skin, leading to the development of a rare but aggressive Merkel cell carcinoma (MCC) in older individuals, especially those with fair skin, male sex, and immunosuppression. The incidence of MCC, caused by MCPyV or UV damage, is increasing globally, with risk factors including male sex, older age, fair skin, intense UV exposure, and immunosuppression. Early diagnosis and prompt treatment are crucial for reducing MCC morbidity and mortality.
Article
Medicine, Research & Experimental
Monique E. Verhaegen, Paul W. Harms, Julia J. Van Goor, Jacob Arche, Matthew T. Patrick, Dawn Wilbert, Haley Zabawa, Marina Grachtchouk, Chia-Jen Liu, Kevin Hu, Michael C. Kelly, Ping Chen, Thomas L. Saunders, Stephan Weidinger, Li-Jyun Syu, John S. Runge, Johann E. Gudjonsson, Sunny Y. Wong, Isaac Brownell, Marcin Cieslik, Aaron M. Udager, Arul M. Chinnaiyan, Lam C. Tsoi, Andrzej A. Dlugosz
Summary: Merkel cell carcinoma (MCC) is an aggressive skin cancer that expresses specific genes similar to skin-resident Merkel cells. Researchers have used ATOH1 to induce MCC development in mice by cellular reprogramming. By conditionally expressing MCPyV TAgs and ATOH1 in mouse epidermal cells, they were able to generate MCC-like tumor cells from hair follicles. The study confirmed the similarity between mouse and human MCCs and revealed that loss of p53 is necessary for the progression of MCC in this mouse model.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Oncology
Roland Houben, Bueke Celikdemir, Thibault Kervarrec, David Schrama
Summary: By studying the cancer-inducing ability of polyomaviruses, researchers have made significant progress in understanding tumor suppressor proteins and have identified Merkel cell polyomavirus (MCPyV) as a human polyomavirus-induced cancer. Intensive research has since uncovered many details about the virus-host interaction and the molecular mechanisms by which MCPyV causes cancer. This review summarizes the current knowledge on MCPyV and MCC and discusses remaining questions.
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Article
Dermatology
Anthony T. Nguyen, Michael Luu, Diana J. Lu, Omid Hamid, Jon Mallen-St Clair, Mark B. Faries, Nima M. Gharavi, Allen S. Ho, Zachary S. Zumsteg
Summary: The number of metastatic lymph nodes is the key factor affecting survival in patients with Merkel cell carcinoma (MCC). A novel nodal classification system was developed, which showed improved concordance compared with the American Joint Committee on Cancer, Eighth Edition.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Lukas Kofler, Katrin Kofler, Claudia Schulz, Helmut Breuninger, Hans-Martin Haefner
Summary: This study analyzed the role of Sentinel lymph node biopsy (SLNB) in assessing lymph node status and survival in high-risk squamous cell carcinoma patients. The results showed that although SLNB is suitable for determining lymph node status, it did not provide any benefit regarding further metastasis or tumor-specific survival.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Review
Otorhinolaryngology
Sophie S. Jang, Morgan E. Davis, David R. Vera, Stephen Y. Lai, Theresa W. Guo
Summary: Sentinel lymph node biopsy has potential clinical utility in the treatment of early stage oral cavity squamous cell carcinoma, but its application should be evaluated in conjunction with factors such as depth of invasion, nodal mapping, and histopathology methods.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Christian Doll, Simon Bigus, Elena Hofmann, Friedrich Mrosk, Claudius Steffen, Felix Thiele, Jan Voss, Kilian Kreutzer, Holger Amthauer, Max Heiland, Steffen Koerdt
Summary: The potential of sentinel lymph node biopsy (SLNB) in patients with recurrent or secondary oral squamous cell carcinoma (OSCC) without clinical signs of lymph node metastases (cN0) was evaluated in this retrospective study. Results showed a detection rate of 88.2% for sentinel lymph nodes, with two cases showing positive SLN. The SLNB had a negative predictive value of 86.7% and a sensitivity of 50.0% as a neck staging procedure.
Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)
