Review
Otorhinolaryngology
Yongyuan Xue, Guoping Li, Tao Xie, Hongyang Xu, Tianrui Xu, Zhengfei Li, Lixiu Zhu, Xin Li, Zhiyao Li, Wei Xiong
Summary: This study systematically reviewed the significance of concurrent chemoradiotherapy for stage II nasopharyngeal cancer. The results showed that in the era of intensity-modulated radiotherapy, concurrent chemoradiotherapy and radiotherapy alone have the same survival benefits and concurrent chemoradiotherapy increases acute hematological toxicity. Subgroup analysis showed that for people with N1 nasopharyngeal cancer at risk of distant metastases, concurrent chemoradiotherapy and radiotherapy alone also had equal survival benefits.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Shan-Shan Yang, Ya-Jun Pang, Zhi-Qiang Wang, Bao-Yu Zhang, Zhi-Qiao Liu, En-Ni Chen, Pu-Yun Ouyang, Fang-Yun Xie
Summary: A risk score model was developed and validated to accurately select high-risk stage II NPC patients for CCRT treatment in the era of IMRT, guiding individualized treatment.
Article
Oncology
YuLin Lai, ChengTao Wang, XingLi Yang, ShaSha He, Yan Wang, Yong Chen
Summary: The efficacy of induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) in stage II nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) was explored. The results showed that adding IC to CCRT or IMRT alone decreased progression-free survival (PFS) and distant metastasis-free survival (DMFS), indicating that IC should not be recommended in stage II NPC patients. There were no significant differences observed in overall survival (OS) and locoregional relapse-free survival (LRRFS) in stage II disease. In addition, high neutrophil-to-lymphocyte ratio was negatively associated with OS, PFS, and DMFS.
Review
Oncology
Wai Tong Ng, Yoke Lim Soong, Yong Chan Ahn, Hussain AlHussain, Horace C. W. Choi, June Corry, Vincent Gregoire, Kevin J. Harrington, Chao Su Hu, Kenneth Jensen, Dora L. Kwong, Johannes A. Langendijk, Quynh Thu Le, Nancy Y. Lee, Jin Ching Lin, Tai Xiang Lu, William M. Mendenhall, Brian O'Sullivan, Enis Ozyar, Jian Ji Pan, Lester J. Peters, Sharon S. Poh, David I. Rosenthal, Giuseppe Sanguineti, Yungan Tao, Joseph T. Wee, Sue S. Yom, Melvin L. K. Chua, Anne W. M. Lee
Summary: The reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging due to the delicate balance needed between achieving local salvage and minimizing treatment toxicities. High-level evidence is lacking, but pragmatic consensus guidelines based on expert opinions provide useful references for decision-making. Through iterative revisions, recommendations with high-to-moderate agreement were formulated regarding general treatment strategies and details of reirradiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Pengjie Ji, Qiongjiao Lu, Xiaoqiang Chen, Yuebing Chen, Xiane Peng, Zhiwei Chen, Cheng Lin, Shaojun Lin, Jingfeng Zong
Summary: This retrospective study aimed to re-evaluate the effect of concurrent chemotherapy in patients with locally advanced nasopharyngeal carcinoma (NPC) in the era of intensity-modulated radiotherapy (IMRT). The results showed that pretreatment EBV DNA level can be used to individualize concurrent chemotherapy for patients with locally advanced NPC.
CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Chen Li, Lijun Tan, Xiao Liu, Xin Wang, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Xiaozhen Wang, Nan Bi, Lei Deng, Wenqing Wang, Tao Zhang, Wenjie Ni, Xiao Chang, Weiming Han, Linrui Gao, Shijia Wang, Zefen Xiao
Summary: The study found that concurrent chemoradiotherapy (CCRT) provides better overall survival (OS) and progression-free survival (PFS) benefits for patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving intensity-modulated radiotherapy (IMRT). Patients in the CCRT group had higher rates of grade 3 leukopenia and radiation esophagitis compared to the RT alone group, with no significant difference in the probability of radiation pneumonitis between the two groups.
Article
Oncology
Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin
Summary: This study compared the efficacy and toxicity of radiotherapy combined with nimotuzumab versus chemoradiotherapy in patients with locally recurrent nasopharyngeal carcinoma. The results showed no significant difference in survival rates between the two groups, but the CRT group had a higher incidence of severe late radiation injuries. Further studies are needed to confirm these findings.
Article
Oncology
Shan Lu, Huiqi Fan, Xueyuan Hu, Xin Li, Yingying Kuang, Deyang Yu, Shanshan Yang
Summary: This study compared different radiotherapy plans for locally advanced nasopharyngeal carcinoma (NPC) and found that helical tomotherapy (HT) and volume-modulated arc therapy (VMAT) had better target homogeneity and conformity. HT also showed the best reduction in doses delivered to organs at risk. VMAT, on the other hand, had the shortest treatment time and improved radiation delivery efficiency.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xing-Li Yang, Guan-Qun Zhou, Li Lin, Lu-Lu Zhang, Fo-Ping Chen, Jia-Wei Lv, Jia Kou, Dan-Wan Wen, Jun Ma, Ying Sun, Yan-Ping Mao
Summary: The study investigated the impact of interruptions during radiation therapy on the survival of nasopharyngeal carcinoma patients. It found that interruptions longer than specific thresholds significantly affected patient survival. Efforts should be made to minimize these interruptions and provide timely treatment.
Article
Oncology
Wai-Tong Ng, Cheuk-Wai Choi, Barton But, Roger K. C. Ngan, Stewart Tung, Ashley C. Cheng, Dora L. W. Kwong, Tai-Xiang Lu, Anthony T. C. Chan, Harry Yiu, Sarah Lee, Frank Wong, Kam-Tong Yuen, Richard J. Chappell, Anne W. M. Lee
Summary: The combination of cisplatin-based induction or adjuvant chemotherapy with concurrent chemoradiotherapy has been found to improve overall survival in patients with locoregionally advanced nasopharyngeal carcinoma. The optimal platinum doses for the concurrent and induction/adjuvant phases were determined to be 160 mg/m(2) and 260 mg/m(2) respectively.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Kai Liao, Hao-Yun Tao, Ze-Jiang Zhan, Wen-Ze Qiu, Rong-Hui Zheng
Summary: The study found that induction chemotherapy plus concurrent chemoradiotherapy under intensity-modulated radiotherapy for locally advanced NPC provides beneficial therapeutic effects and warrants further investigation.
ONCOLOGY RESEARCH AND TREATMENT
(2021)
Article
Oncology
Motoko Tachihara, Kayoko Tsujino, Takeaki Ishihara, Hidetoshi Hayashi, Yuki Sato, Takayasu Kurata, Shunichi Sugawara, Yoshimasa Shiraishi, Shunsuke Teraoka, Koichi Azuma, Haruko Daga, Masafumi Yamaguchi, Takeshi Kodaira, Miyako Satouchi, Mototsugu Shimokawa, Nobuyuki Yamamoto, Kazuhiko Nakagawa
Summary: This study investigated the efficacy and safety of durvalumab immunotherapy combined with concurrent radiotherapy for patients with locally advanced NSCLC. The results showed that this treatment approach achieved a high rate of 12-month progression-free survival and had tolerable adverse events. These findings suggest that durvalumab immunotherapy combined with curative radiotherapy may be a promising treatment option.
Review
Medicine, Research & Experimental
Xin Li, Lei Li, Ruimei Sun, Jingyan Gao, Zhengfei Li, Yongyuan Xue, Lixiu Zhu, Tianrui Xu, Chuanzheng Sun, Yan Xi, Wei Xiong
Summary: This meta-analysis compared the efficacy and toxicities of weekly and triweekly cisplatin regimens in patients with locally advanced nasopharyngeal cancer (LA-NPC). The results showed no significant difference in overall survival, distant metastasis-free survival, locoregional recurrence-free survival, and disease-free survival between the two regimens. However, the weekly cisplatin regimen was more likely to cause grade >= 3 hematological toxicity events. Subgroup analyses suggested similar survival rates for patients undergoing concurrent chemoradiotherapy (CCRT) and CCRT plus adjuvant chemotherapy (AC).
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Oncology
Albrecht Stenzinger, Arndt Vogel, Ulrich Lehmann, Angela Lamarca, Paul Hofman, Luigi Terracciano, Nicola Normanno
Summary: Cholangiocarcinomas are a heterogeneous group of tumors with distinct genomic alterations. Next-generation sequencing is a powerful tool for identifying gene variants and guiding personalized treatment for patients with cholangiocarcinomas. Understanding the use of NGS in molecular profiling is crucial for healthcare professionals to optimize treatment outcomes.
CANCER TREATMENT REVIEWS
(2024)