Article
Endocrinology & Metabolism
Wenbo Zou, Hao Wang, Dingguo Wu, Yunyang Wu, Kuiping Zhou, Yuanshu Lian, Gengyun Chang, Yuze Feng, Jifeng Liang, Gao Huang
Summary: This study found that FAM83A plays a vital role as a prognostic indicator and potential oncogene in pancreatic cancer. The AL049555.1/hsa-miR-129-5p axis was identified as the important upstream ncRNA-mediated pathway of FAM83A in pancreatic cancer. Additionally, FAM83A expression was associated with immune cell infiltration and tumorigenesis. In conclusion, ncRNA-mediated upregulation of FAM83A is linked to poor long-term survival and immune cell infiltration in pancreatic cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Shan, Xiaoli Zhang, Guanghui Zhou, XiuHai Ji, Yinjie Gu
Summary: This study found that serum PGRN levels were significantly elevated in patients with sepsis and positively correlated with inflammatory markers, sepsis-related organ failure assessment scores, and acute physiology and chronic health evaluation II scores. Additionally, PGRN had a higher predictive effect and was an independent predictor for 28-day mortality risk in sepsis.
Article
Immunology
Pengxiang Gao, Kang Zou, Li Xiao, Hongxia Zhou, Xinping Xu, Zhenguo Zeng, Wei Zhang
Summary: This study revealed the clinical value of PTGES3 in lung adenocarcinoma (LUAD) in terms of prognosis and tumor immune-infiltration. Up-regulated PTGES3 was associated with worse overall survival in LUAD and acted as an independent prognostic biomarker. PTGES3 also played a role in regulating the cell cycle and immune infiltrates in LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Jiyu Meng, Xuelian Ruan, Fangyi Wei, Qin Xue
Summary: This study comprehensively assessed the expression and clinical relevance of ENPP2 in hepatocellular carcinoma (HCC). ENPP2 expression was found to be associated with clinical stage and is a significant prognostic factor for worse outcomes in HCC patients. The diagnostic value of ENPP2 expression in HCC was confirmed, and gene set enrichment analysis identified pathways enriched in HCC patients with high ENPP2 expression. Overall, ENPP2 is highly expressed in HCC and is a potential independent molecular marker for the diagnosis and prognosis of HCC.
Article
Oncology
Yong-Qu Zhang, Fan Zhang, Yun-Zhu Zeng, Min Chen, Wen-He Huang, Jun-Dong Wu, Wei-Ling Chen, Wen-Liang Gao, Jing-Wen Bai, Rui-Qin Yang, Huan-Cheng Zeng, Xiao-Long Wei, Guo-Jun Zhang
Summary: The study examined the expression of p53 and Twist1 in breast cancer and their association with patient prognosis, indicating that co-expression of these two factors is correlated with advanced stage, shorter disease-free survival, and overall survival in breast cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan-Chih Peng, Chien-Hui Wu, Yu-Wen Tien, Tzu-Pin Lu, Yu-Hsin Wang, Bang-Bin Chen
Summary: Preoperative sarcopenia assessed by CT is a poor prognostic factor for overall survival in pancreatic cancer patients after pancreaticoduodenectomy (PD).
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mingrui Shao, Shize Yang, Siyuan Dong
Summary: Through analysis of gene expression datasets, MCM10 was identified as a potential prognostic biomarker for lung adenocarcinoma, with diagnostic and therapeutic value. Overexpression of MCM10 was found to correlate with poor prognosis and larger tumor size.
Article
Oncology
Lingling Lu, Huaxiang Wang, Jian Fang, Jiaolong Zheng, Bang Liu, Lei Xia, Dongliang Li
Summary: OAS1 expression is elevated in pancreatic cancer and is associated with poor prognosis, potentially linked to immune cell abundance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ricardo A. Leon-Letelier, Ali H. Abdel Sater, Yihui Chen, Soyoung Park, Ranran Wu, Ehsan Irajizad, Jennifer B. Dennison, Hiroyuki Katayama, Jody V. Vykoukal, Samir Hanash, Edwin J. Ostrin, Johannes F. Fahrmann
Summary: We previously reported that elevated KYNU gene expression is associated with NRF2-activated cancers and an immunosuppressive tumor microenvironment. In this study, we explored the relevance of NRF2-mediated KYNU upregulation across multiple cancer types and found that increased KYNU expression is prognostic for poor overall survival in several cancer types. Our study highlights the activation of the NRF2-KYNU axis as a multi-cancer phenomenon and supports the relevance of tumoral KYNU as a marker of tumor immunosuppression and as a prognostic marker for poor overall survival.
Article
Biochemistry & Molecular Biology
Sitong Wang, Linaer Gu, Lili Huang, Juemin Fang, Zhuqing Liu, Qing Xu
Summary: PYCR2 has been shown to be upregulated in various cancer types, correlating with poor patient prognosis and malignant clinicopathological characteristics. It is identified as an independent predictor of survival in colon cancer patients, and knocking down PYCR2 disrupts the activities of colon cancer cells. Gene set enrichment analysis suggests high PYCR2 expression correlates with the enrichment of specific signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Qing Hua, Tianjiao Li, Yixuan Liu, Xuefang Shen, Xiaoyan Zhu, Pingbo Xu
Summary: The study revealed that KLK8 is up-regulated in PDAC tumor tissues and serves as an independent prognostic factor for PDAC. KLK8 overexpression in Mia-paca-2 and Panc-1 cells promotes cell proliferation and inhibits apoptosis, potentially through activation of the PI3K/Akt/mTOR and Notch pathways. Additionally, KLK8-induced effects can be attenuated by inhibitors for PI3K, Akt, and mTOR, suggesting a potential therapeutic target for PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zigao Huang, Hao Lai, Jiankun Liao, Jinghua Cai, Baojia Li, Linghou Meng, Wentao Wang, Xianwei Mo, Haiquan Qin
Summary: The study revealed that in patients with colon adenocarcinoma, higher ADAM12 expression was associated with worse prognosis, and that ADAM12 plays important roles in regulating the extracellular matrix and recruiting immune cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yufei Zhu, Dijie Zheng, Linhan Lei, Kun Cai, Huahua Xie, Jian Zheng, Chao Yu
Summary: This study aimed to explore the expression and clinical significance of SDC4 in pancreatic adenocarcinoma (PAAD). The results showed that SDC4 was highly expressed in PAAD tissues and correlated with reduced overall survival. Pathway analysis also revealed the enrichment of important pathways associated with SDC4. High expression of SDC4 was associated with metastatic differentiation, TNM stage, lymphatic metastasis, and lower 3-year survival rate, and it was identified as an independent risk factor affecting postoperative survival.
Article
Genetics & Heredity
Guojun Lu, Ying Zhou, Chenxi Zhang, Yu Zhang
Summary: This study demonstrated that upregulated LIMK1 expression is significantly correlated with poor survival and immune infiltrates in lung adenocarcinoma, indicating its potential as a biomarker for poor prognosis and a target for immune therapy in lung adenocarcinoma.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Jianmin Zeng, Man Li, Huasheng Shi, Jianhui Guo
Summary: This study revealed that FGD6 was significantly overexpressed in GC tissues and associated with higher histological grade, stage, and poor prognosis. Multivariate Cox regression analysis indicated that FGD6 was an independent prognostic factor for survival in GC patients.
FRONTIERS IN MEDICINE
(2021)