Oncogenic role of kinesin proteins and targeting kinesin therapy

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

(2015) Mourad Sanhaji et al.   Oncotarget

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

(2012) E. Komlodi-Pasztor et al.   CLINICAL CANCER RESEARCH

A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies

(2012) John F. Gerecitano et al.   INVESTIGATIONAL NEW DRUGS

Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers

(2012) Eiji Oki et al.   JOURNAL OF GASTROENTEROLOGY

Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study

(2012) Guang-Rong Yan et al.   PROTEOMICS

Phase I dose-escalation and pharmacokinetic study of ispinesib, a kinesin spindle protein inhibitor, administered on days 1 and 15 of a 28-day schedule in patients with no prior treatment for advanced breast cancer

(2011) Henry L. Gomez et al.   ANTI-CANCER DRUGS

Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer

(2011) Min Han Tan et al.   BREAST CANCER RESEARCH AND TREATMENT

A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias

(2011) Hanna Jean Khoury et al.   CANCER

First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer

(2011) Vincent Chung et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL

(2011) X Liu et al.   CANCER GENE THERAPY

Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E

(2011) Ying Huang et al.   CELL CYCLE

Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas

(2011) Li Bie et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer

(2011) Brigitte L. Thériault et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia

(2011) H. M. Kantarjian et al.   INVESTIGATIONAL NEW DRUGS

A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors

(2011) Kyle Holen et al.   INVESTIGATIONAL NEW DRUGS

A new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti-tumour effect

(2011) Xin-Ran Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Downregulation of KIF23 suppresses glioma proliferation

(2011) Satoshi Takahashi et al.   JOURNAL OF NEURO-ONCOLOGY

Overexpression of Mitotic Centromere-Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel

(2011) A. Ganguly et al.   MOLECULAR CANCER THERAPEUTICS

Mitosis is not a key target of microtubule agents in patient tumors

(2011) Edina Komlodi-Pasztor et al.   Nature Reviews Clinical Oncology

Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program

(2011) Richard B. Lock et al.   PEDIATRIC BLOOD & CANCER

Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes

(2010) Sigrid Rouam et al.   BMC BIOINFORMATICS

Overcoming Taxane and Anthracycline Resistance

(2010) Amelia Zelnak   Breast Journal

A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose

(2010) Kyle D. Holen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin

(2010) Xia Ding et al.   CELL RESEARCH

How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays

(2010) Linda Wordeman   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo

(2010) Jie Gao et al.   TUMOR BIOLOGY

Kinesin motor proteins as targets for cancer therapy

(2009) Dennis Huszar et al.   CANCER AND METASTASIS REVIEWS

Overexpression of Kinesins Mediates Docetaxel Resistance in Breast Cancer Cells

(2009) S. De et al.   CANCER RESEARCH

The Expression of Three Genes in Primary Non-Small Cell Lung Cancer Is Associated with Metastatic Spread to the Brain

(2009) H. Grinberg-Rashi et al.   CLINICAL CANCER RESEARCH

Targeting of Integrin β1 and Kinesin 2α by MicroRNA 183

(2009) Guorong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian end binding proteins control persistent microtubule growth

(2009) Yulia Komarova et al.   JOURNAL OF CELL BIOLOGY

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma

(2009) I. Abiatari et al.   MOLECULAR CANCER THERAPEUTICS

Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

(2009) A Sarangi et al.   ONCOGENE

Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue

(2009) Cheng-Qin Wang et al.   ORAL ONCOLOGY

Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer

(2008) K Ishikawa et al.   BRITISH JOURNAL OF CANCER

A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

(2008) S P Blagden et al.   BRITISH JOURNAL OF CANCER

Microtubule Active Agents: Beyond the Taxane Frontier

(2008) P. G. Morris et al.   CLINICAL CANCER RESEARCH

Targeting the Kinesin Spindle Protein: Basic Principles and Clinical Implications

(2008) V. Sarli et al.   CLINICAL CANCER RESEARCH

A germline mutation of the KIF1Bβ gene on 1p36 in a family with neural and nonneural tumors

(2008) I-Tien Yeh et al.   HUMAN GENETICS

A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepatocellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168)

(2008) Jennifer J. Knox et al.   INVESTIGATIONAL NEW DRUGS

Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration

(2007) Kiven E. Lukong et al.   CELLULAR SIGNALLING