Article
Environmental Sciences
Yuhe Gao, Jacek M. Mazurek, Yaming Li, David Blackley, David N. Weissman, Shirley V. Burton, Waqas Amin, Douglas Landsittel, Michael J. Becich, Ye Ye
Summary: This study examines the work histories and survival time of patients with suspected exposure to asbestos. The most frequent cases of mesothelioma occurred in patients working in manufacturing, construction, and education services. Males or individuals over 40 tended to work in traditionally asbestos-associated industries, while females or individuals aged 20-40 tended to work in non-traditionally associated industries. The results highlight the importance of considering all potential sources of asbestos exposure when evaluating mesothelioma patients.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Karen Walker-Bone, Geza Benke, Ewan MacFarlane, S. Klebe, Ken Takahashi, Fraser Brims, Malcolm Ross Sim, Tim R. Driscoll
Summary: Mesothelioma, a rare and deadly cancer associated with asbestos exposure, continues to be diagnosed in Australia despite the ban on asbestos since 2003. The Australian Mesothelioma Registry was established to gather comprehensive data on incidence, mortality, and asbestos exposure. Results show a decline in incidence and mortality rates due to effective control of occupational asbestos use, but the rates among women remain stable, suggesting other sources of exposure.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Alessandro Marinaccio, Davide Di Marzio, Carolina Mensi, Dario Consonni, Carmela Gioscia, Enrica Migliore, Carlo Genova, Roberta Rossetto Giaccherino, Silvia Eccher, Stefano Murano, Vera Comiati, Veronica Casotto, Corrado Negro, Lucia Mangone, Lucia Miligi, Sara Piro, Alessia Angelini, Iolanda Grappasonni, Gabriella Madeo, Ilaria Cozzi, Laura Ancona, Tommaso Staniscia, Francesco Carrozza, Domenica Cavone, Luigi Vimercati, Michele Labianca, Federico Tallarigo, Giuseppe Cascone, Massimo Melis, Michela Bonafede, Alberto Scarselli, Alessandra Binazzi
Summary: Mesothelioma incidence surveillance and individual research on asbestos exposure are important for monitoring health effects and preventing exposure risks. Young mesothelioma cases with non-occupational asbestos exposure signal potential clusters of cases.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Environmental Sciences
C. Airoldi, C. Magnani, F. Lazzarato, D. Mirabelli, S. Tunesi, D. Ferrante
Summary: This study found an increasing pattern of mesothelioma risk in the area around a big AC factory, with secondary clusters of cases detected due to local exposure points, possibly associated with the use of asbestos materials.
ENVIRONMENTAL HEALTH
(2021)
Review
Oncology
Fraser Brims
Summary: Mesothelioma is a cancer of the lining of the lungs caused by breathing in asbestos fibres, which remains a challenge in terms of treatment and has an uncertain survival time. The disease mainly occurs in males, with a clear risk associated with exposure to asbestos. There have been significant advances in diagnosis, but further research and treatment are still needed.
Article
Environmental Sciences
Alessandra Binazzi, Davide Di Marzio, Marina Verardo, Enrica Migliore, Lucia Benfatto, Davide Malacarne, Carolina Mensi, Dario Consonni, Silvia Eccher, Guido Mazzoleni, Vera Comiati, Corrado Negro, Antonio Romanelli, Elisabetta Chellini, Alessia Angelini, Iolanda Grappasonni, Gabriella Madeo, Elisa Romeo, Annamaria Di Giammarco, Francesco Carrozza, Italo F. Angelillo, Domenica Cavone, Luigi Vimercati, Michele Labianca, Federico Tallarigo, Rosario Tumino, Massimo Melis, Michela Bonafede, Alberto Scarselli, Alessandro Marinaccio
Summary: Asbestos exposure among workers in the construction sector in Italy remains a concern, with an increasing trend of mesothelioma cases in this industry. This study describes the characteristics of these cases and highlights the need to assess and prevent asbestos exposure in the construction sector.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
A. Scarselli, A. Marinaccio, S. Iavicoli
Summary: The study aimed to estimate the potential health impact of naturally occurring asbestos from ophiolitic outcrops in certain areas of Calabria, southern Italy. By analyzing employment, compensation, and mortality data, statistically significant excess risks were observed in several municipalities, some of which were located in areas where asbestos outcrops had been identified.
Review
Biochemistry & Molecular Biology
Phillip Munson, Arti Shukla
Summary: This review summarizes the role of exosomes in the development of malignant mesothelioma (MM), and discusses their potential in detection and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yasuko Nagamatsu, Yumi Sakyo, Edward Barroga, Riwa Koni, Yuji Natori, Mitsunori Miyashita
Summary: This study investigated the prevalence and associated factors of depression and complicated grief among bereaved family members of malignant pleural mesothelioma patients in Japan. The results showed that family members who were not compensated and experienced financial impacts were more likely to have depression, while those who were not satisfied with care and had deceased relatives undergo surgery were more likely to have complicated grief. Routine screening and grief care, as well as financial support and improved care, are recommended for these bereaved family members.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Cita Zupanc, Alenka Franko, Danijela Strbac, Metoda Dodic Fikfak, Viljem Kovac, Vita Dolzan, Katja Goricar
Summary: The study evaluated serum calretinin as a potential biomarker in asbestos-related diseases, particularly in predicting malignant mesothelioma with high accuracy. Combining calretinin and SMRP showed the highest predictive value in distinguishing MM from other asbestos-related diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Respiratory System
Marie Shamseddin, Joanna Obacz, Mathew J. Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak
Summary: Malignant pleural mesothelioma is an aggressive cancer with a median survival of 12-18 months and existing models have limitations, so new technologies are being developed to study effective treatments.
Article
Oncology
Pietro Gino Barbieri, Dario Consonni, Anna Somigliana
Summary: The study found no significant relationship between asbestos lung burden and survival, with histologic subtype being the strongest prognostic determinant.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Toxicology
Maya-Liliana Avramescu, Christian Potiszil, Tak Kunihiro, Kazunori Okabe, Eizo Nakamura
Summary: This study investigates the growth of asbestos fibers in the lungs of smokers and non-smokers. It is found that smokers have denser and more iron-rich asbestos fiber structures, possibly due to a more uniform supply of iron from smoking. In addition, asbestos fibers may accrete mucopolysaccharides to accumulate iron and form asbestos ferruginous bodies. The results suggest that oxidative stress may not be the main driver for the onset of malignant mesothelioma.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Cai-Pu Chun, Lin-Xie Song, Hong-Pan Zhang, Dan -Dan Guo, Gui-Xuan Xu, Ya Li, Xin Xin, Jiachen Cao, Feng Li
Summary: This article presents a rare case of malignant peritoneal mesothelioma (MPM) in a 67-year-old male patient, with severe abdominal pain, bloating, and bloody ascites. The diagnosis was confirmed through cytology and laparoscopic exploratory biopsy. The characteristics of signs and clinical manifestations in this case are less common.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Oncology
Katsuyuki Hotta, Nobukazu Fujimoto
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Medicine, General & Internal
Paul Baas, Arnaud Scherpereel, Anna K. Nowak, Nobukazu Fujimoto, Solange Peters, Anne S. Tsao, Aaron S. Mansfield, Sanjay Popat, Thierry Jahan, Scott Antonia, Youssef Oulkhouir, Yolanda Bautista, Robin Cornelissen, Laurent Greillier, Francesco Grossi, Dariusz Kowalski, Jeronimo Rodriguez-Cid, Praveen Aanur, Abderrahim Oukessou, Christine Baudelet, Gerard Zalcman
Summary: Nivolumab plus ipilimumab demonstrated significant improvement in overall survival compared to standard chemotherapy for unresectable malignant pleural mesothelioma. This first-in-class treatment regimen has been approved for previously untreated patients in the USA and showed promising outcomes with manageable adverse events.
Article
Oncology
Kazuya Nishii, Masaaki Inoue, Hideto Obata, Yutaka Ueda, Toshiyuki Kozuki, Masahiro Yamasaki, Tomonori Moritaka, Yoshikazu Awaya, Keisuke Sugimoto, Kenichi Gemba, Shoichi Kuyama, Hirohisa Ichikawa, Takuo Shibayama, Tetsuya Kubota, Masahiro Kodani, Daizo Kishino, Nobukazu Fujimoto, Nobuhisa Ishikawa, Yukari Tsubata, Tomoya Ishii, Kazunori Fujitaka, Katsuyuki Hotta, Katsuyuki Kiura
Summary: The umbrella-type CS-Lung-003 registry integrates multiple linked studies to address various clinical questions on daily practice patterns of lung cancer treatment. This collaborative approach enables researchers to generate results across multiple domains of study and provide answers to questions raised by other researchers. Through analysis of each linked study, the registry aims to comprehensively elucidate actual daily practice patterns in lung cancer treatment.
Article
Oncology
Naoko Sueoka-Aragane, Chiho Nakashima, Hironori Yoshida, Naohisa Matsumoto, Kentaro Iwanaga, Noriyuki Ebi, Akihiro Nishiyama, Kazuhiro Yatera, Shoichi Kuyama, Minoru Fukuda, Sunao Ushijima, Hitomi Umeguchi, Daijiro Harada, Kosuke Kashiwabara, Takayuki Suetsugu, Nobukazu Fujimoto, Fumihiro Tanaka, Hidetaka Uramoto, Chiharu Yoshii, Katsumi Nakatomi, Genju Koh, Nobuhiko Seki, Keisuke Aoe, Kaname Nosaki, Koji Inoue, Ayako Takamori, Atsushi Kawaguchi
Summary: This study investigated the predictive value of comprehensive NGS analysis of ctDNA in NSCLC patients treated with osimertinib after progressing on EGFR-TKI treatment. The study found that T790 M allele fraction in ctDNA and total number of alterations detected by NGS may be associated with treatment response and early resistance, respectively. Additionally, loss of T790 M was observed in 32% of patients after acquiring resistance to osimertinib.
Article
Critical Care Medicine
Timothy A. Yap, Kazuhiko Nakagawa, Nobukazu Fujimoto, Kozo Kuribayashi, Tormod Kyrre Guren, Luana Calabro, Ronnie Shapira-Frommer, Bo Gao, Steven Kao, Ignacio Matos, David Planchard, Arkendu Chatterjee, Fan Jin, Kevin Norwood, Hedy L. Kindler
Summary: Pembrolizumab demonstrated durable antitumor activity and manageable toxicity in patients with advanced MPM, regardless of PD-L1 status. Our data support the programmed death 1 (PD-1) and PD-L1 pathway as a potential therapeutic target in some patients with previously treated mesothelioma but biomarkers that can effectively identify such patients are yet to be elucidated.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Takumi Kishimoto, Yoko Kojima, Nobukazu Fujimoto
Summary: SLPI levels in pleural effusion can help distinguish between benign asbestos pleural effusion (BAPE) and early-stage malignant pleural mesothelioma (MPM). The combination of SLPI and CYFRA21-1 biomarkers can improve the differentiation between BAPE and MPM.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
S. Peters, A. Scherpereel, R. Cornelissen, Y. Oulkhouir, L. Greillier, M. A. Kaplan, T. Talbot, I Monnet, S. Hiret, P. Baas, A. K. Nowak, N. Fujimoto, A. S. Tsao, A. S. Mansfield, S. Popat, X. Zhang, N. Hu, D. Balli, T. Spires, G. Zalcman
Summary: In patients with unresectable malignant pleural mesothelioma, first-line nivolumab plus ipilimumab showed continued long-term survival benefit over chemotherapy with a manageable safety profile, based on 3 years of follow-up data.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Yosuke Miyamoto, Toshiyuki Kozuki, Keisuke Aoe, Sae Wada, Daijiro Harada, Michihiro Yoshida, Jun Sakurai, Katsuyuki Hotta, Nobukazu Fujimoto
Summary: The JME-001 trial aimed to evaluate the efficacy and safety of cisplatin, pemetrexed, and nivolumab as first-line therapy in malignant pleural mesothelioma. Preliminary results showed a high objective response rate and disease control rate in the majority of patients, but also a significant rate of adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Kenichiro Kudo, Kazuya Nishii, Go Makimoto, Nobuhisa Ishikawa, Yukari Tsubata, Masahiro Kodani, Nobukazu Fujimoto, Masahiro Yamasaki, Tetsuya Kubota, Nagio Takigawa, Kazunori Fujitaka, Nobuhiro Kanaji, Takuo Shibayama, Junko Itano, Chihiro Ando, Katsuyuki Hotta, Katsuyuki Kiura
Summary: Repeat rebiopsy may increase the ability to detect T790M mutation positivity rate in patients with T790M-negative non-small-cell lung cancer (NSCLC) detected by the first rebiopsy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Arnaud Scherpereel, Scott Antonia, Yolanda Bautista, Francesco Grossi, Dariusz Kowalski, Gerard Zalcman, Anna K. Nowak, Nobukazu Fujimoto, Solange Peters, Anne S. Tsao, Aaron S. Mansfield, Sanjay Popat, Xiaowu Sun, Rachael Lawrance, Xiaoqing Zhang, Melinda J. Daumont, Bryan Bennett, Mike McKenna, Paul Baas
Summary: Nivolumab + ipilimumab significantly prolonged overall survival and improved disease-related symptoms and health-related quality of life in patients with unresectable malignant pleural mesothelioma. Compared to chemotherapy, Nivolumab + ipilimumab reduced the risk of symptom and quality of life deterioration and delayed disease progression.
Article
Medicine, General & Internal
Takaaki Tanaka, Soma Nii, Hidenaru Yamaoka, Nobukazu Fujimoto
Summary: A man in his 70s was diagnosed with adenocarcinoma of the lung and received carboplatin, paclitaxel, and thoracic radiotherapy. After recurrence, he was treated with osimertinib, which eventually led to cardiac failure. Discontinuation of osimertinib resulted in gradual improvement in cardiac function. Osimertinib-related cardiotoxicity should be taken into consideration.
Article
Oncology
Seiki Hasegawa, Yasushi Shintani, Teruhisa Takuwa, Keisuke Aoe, Katsuya Kato, Nobukazu Fujimoto, Yasuhiro Hida, Masahiro Morise, Yasumitsu Moriya, Takao Morohoshi, Hidemi Suzuki, Masayuki Chida, Shunsuke Endo, Mitsutaka Kadokura, Meinoshin Okumura, Satoshi Hattori, Hiroshi Date, Ichiro Yoshino
Summary: A nationwide prospective registry for newly diagnosed and untreated pleural mesothelioma in Japan was conducted, and data on patients' survival were collected. The study found that surgery significantly prolonged overall survival, and tumor shape and thickness were important prognostic factors.
Article
Oncology
Takashi Ninomiya, Naoyuki Nogami, Toshiyuki Kozuki, Daijiro Harada, Toshio Kubo, Kadoaki Ohashi, Eiki Ichihara, Shoichi Kuyama, Kenichiro Kudo, Akihiro Bessho, Makoto Sakugawa, Nobukazu Fujimoto, Keisuke Aoe, Daisuke Minami, Keisuke Sugimoto, Nobuaki Ochi, Nagio Takigawa, Katsuyuki Hotta, Yoshinobu Maeda, Katsuyuki Kiura
Summary: This study demonstrated that combination therapy with afatinib and bevacizumab may improve survival outcomes in patients with EGFR-mutant advanced non-small-cell lung cancer, showing promise for future treatment options.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yuki Takigawa, Daisuke Mizuno, Norichika Iga, Nobukazu Fujimoto
Summary: This report describes a case of a 46-year-old woman who presented with pneumothorax during menstruation and underwent multiple surgeries. The blueberry spot in the pericardium was identified as the source of bleeding during reoperation, confirming the diagnosis of heterotopic endometriosis.
Article
Oncology
Shigeru Tanzawa, Sunao Ushijima, Kazuhiko Shibata, Takuo Shibayama, Akihiro Bessho, Kyoichi Kaira, Toshihiro Misumi, Kenshiro Shiraishi, Noriyuki Matsutani, Hisashi Tanaka, Megumi Inaba, Terunobu Haruyama, Junya Nakamura, Takayuki Kishikawa, Masanao Nakashima, Keiichi Iwasa, Keiichi Fujiwara, Tadashi Kohyama, Shoichi Kuyama, Naoki Miyazawa, Tomomi Nakamura, Hiroshi Miyawaki, Hiroo Ishida, Naohiro Oda, Nobuhisa Ishikawa, Ryotaro Morinaga, Kei Kusaka, Nobukazu Fujimoto, Toshihide Yokoyama, Kenichi Gemba, Takeshi Tsuda, Hideyuki Nakagawa, Hirotaka Ono, Tetsuo Shimizu, Morio Nakamura, Sojiro Kusumoto, Ryuji Hayashi, Hiroki Shirasaki, Nobuaki Ochi, Keisuke Aoe, Nobuhiro Kanaji, Kosuke Kashiwabara, Hiroshi Inoue, Nobuhiko Seki
Summary: This study aims to evaluate the efficacy and safety of consolidation therapy with durvalumab following the SP regimen in Japanese patients with LA-NSCLC, with a focus on PFS and OS. The SP regimen is expected to have lower incidences of adverse effects and higher success rates in transitioning to durvalumab after chemoradiotherapy, potentially leading to improved outcomes.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)