Article
Cell Biology
Minle Li, Xue Zhao, Hongmei Yong, Jian Xu, Pengfei Qu, Shuxi Qiao, Pingfu Hou, Zhongwei Li, Sufang Chu, Junnian Zheng, Jin Bai
Summary: Transketolase (TKT), an important enzyme in the pentose phosphate pathway, plays a crucial role in maintaining ribose 5-phosphate levels and cell growth. Recent studies have shown that TKT is not only involved in liver cancer development but also in colorectal cancer progression. Abnormal upregulation of TKT expression is associated with poor prognosis in colorectal cancer, and TKT promotes colorectal cancer cell growth and metastasis by enhancing glycolysis through AKT phosphorylation.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yongsheng Huang, Sijia Liu, Mengjie Shan, Sophie C. Hagenaars, Wilma E. Mesker, Danielle Cohen, Lin Wang, Zhi Zheng, Peter Devilee, Rob A. E. M. Tollenaar, Zhangfu Li, Yongmei Song, Long Zhang, Dan Li, Peter Ten Dijke
Summary: RNF12, overexpressed in invasive breast cancers, promotes migration and invasion of breast cancer cells through its interaction with the AKT signaling pathway. Phosphorylation of AKT induces nuclear localization of RNF12 and accelerates the degradation of SMAD7 mediated by RNF12. Moreover, RNF12 expression is positively correlated with phosphorylated AKT and phosphorylated SMAD2 levels.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Lauren A. Hapach, Shawn P. Carey, Samantha C. Schwager, Paul Taufalele, Wenjun Wang, Jenna A. Mosier, Nerymar Ortiz-Otero, Tanner J. McArdle, Zachary E. Goldblatt, Marsha C. Lampi, Francois Bordeleau, Jocelyn R. Marshall, Isaac M. Richardson, Jiahe Li, Michael R. King, Cynthia A. Reinhart-King
Summary: This study reveals that weakly migratory breast cancer cell subpopulation is highly metastatic and regulated by E-cadherin, emphasizing the discrepancy between cancer cell migration and metastasis.
Article
Multidisciplinary Sciences
Changhu Lee, Min Kim, Chanho Park, Woobeen Jo, Jeong Kon Seo, Sahee Kim, Jiyoung Oh, Chu-Sook Kim, Han Suk Ryu, Kyung-Hun Lee, Jiyoung Park
Summary: Hyperglycemia is a risk factor for breast cancer-related morbidity and mortality. Hyperglycemia induces Neuregulin 1 (Nrg1) overexpression in breast cancer, which subsequently promotes tumor progression. The study reveals that hyperglycemia causes active histone modifications at the Nrg1 enhancer, leading to enhanceosome complex formation and upregulation of Nrg1 expression.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Jiannan Cui, Coco Duizer, Lieneke Bouwman, Kristel S. van Rooijen, Carlos G. P. Voogdt, Jos P. M. van Putten, Marcel R. de Zoete
Summary: Authors identified ADP-heptose and/or related heptose phosphates released by Campylobacter jejuni as a potent activator of inflammation in intestinal epithelial cells, signaling through the ALPK1 receptor. These results suggest a potential therapeutic target to treat Campylobacter infection and elucidate the virulence mechanisms involved in the development of bacterial enteritis.
Article
Multidisciplinary Sciences
Jiahui Wei, Yu Ding, Xinmiao Liu, Qing Liu, Yiran Lu, Song He, Bao Yuan, Jiabao Zhang
Summary: Eupafolin demonstrated significant inhibition on proliferation, migration, and invasion abilities of breast cancer cells, while promoting apoptosis and blocking cell proliferation in the S phase. It induced autophagy and inhibited multiple signaling pathways like PI3K/AKT, MAPKs, and NF-kappa B. In addition, it showed anti-angiogenic activity and partially mediated its anti-breast cancer effects through Cav-1.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Shin Ung Kang, Soo Youn Cho, Hyojin Jeong, Jinil Han, Ha Yeong Chae, Hobin Yang, Chang Ohk Sung, Yoon-La Choi, Young Kee Shin, Mi Jeong Kwon
Summary: The study demonstrated that MMP11 expression in mononuclear inflammatory cells, predominantly macrophages, is an independent negative prognostic factor in breast cancer. Furthermore, MMP11-overexpressing macrophages promote migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling, suggesting a pro-tumoral role of MMP11 in macrophages in HER2-positive breast cancer through interaction with cancer cells and other cells in the tumor microenvironment.
LABORATORY INVESTIGATION
(2022)
Article
Hematology
Timon A. Bloedjes, Guus de Wilde, Gerarda H. Khan, Timothy C. Ashby, John D. Shaughnessy Jr, Fenghuang Zhan, Riekelt H. Houtkooper, Richard J. Bende, Carel J. M. van Noesel, Marcel Spaargaren, Jeroen E. J. Guikema
Summary: Metabolic alterations play a critical role in cancer cell transformation and survival under stress conditions. In multiple myeloma (MM), increased glycolysis and oxidative phosphorylation are associated with recurrent genetic aberrations that drive MM cell proliferation and survival. We demonstrate that negative regulation of the FOXO transcription factors by AKT is crucial for maintaining the metabolic adaptability of MM cells.
Article
Biochemistry & Molecular Biology
Kelie Chen, Xiaoyu Yuan, Shengchao Wang, Fang Zheng, Zhiqin Fu, Zhangjin Shen, Xiaodong Cheng, Yuwei Wang, Song Tang, Heng Ni, Fang Wang, Guang Lu, Yihua Wu, Dajing Xia, Weiguo Lu
Summary: Peritoneal metastasis is a key feature of advanced ovarian cancer. The protein MAP4K4 was found to be highly expressed in metastatic sites and its increased expression was associated with poorer survival and more advanced stage. Down regulation of MAP4K4 inhibited cancer cell adhesion, migration, and invasion. MAP4K4 was also found to stabilize N-cadherin by suppressing its cleavage, leading to N-cadherin stabilization and promoting ovarian cancer metastasis. Targeting MAP4K4 may be a potential therapeutic approach for ovarian cancer patients.
Article
Medicine, Research & Experimental
Bo Liu, Zhaoqi Liu, Sisi Chen, Michelle Ki, Caroline Erickson, Jorge S. Reis-Filho, Benjamin H. Durham, Qing Chang, Elisa de Stanchina, Yiwei Sun, Raul Rabadan, Omar Abdel-Wahab, Sarat Chandarlapaty
Summary: Hotspot mutations in SF3B1 play a significant role in promoting abnormal splicing in breast cancer, leading to activation of AKT and NF-kappa B signaling pathways, enhanced cell migration, and accelerated tumor development.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Nadar Manimaran Vinita, Umapathy Devan, Sabapathi Durgadevi, Selvaraj Anitha, Dhamodharan Prabhu, Sundarraj Rajamanikandan, Muthusamy Govarthanan, Ananthanarayanan Yuvaraj, Muniyandi Biruntha, Arockiam Antony Joseph Velanganni, Jeyaraman Jeyakanthan, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jaabir, Ponnuchamy Kumar
Summary: This study reports the use of gold nanotriangles (AuNTs) with anionic and cationic surface charge conjugating triphenylphosphonium (TPP) for targeting breast cancer cells with 5-aminoleuvinic acid (5-ALA) based photodynamic therapy (PDT). The optimized surface charge of AuNTs can kill breast cancer cells, and when combined with 5-ALA and PDT, the cationic AuNTs with TPP show improved cellular toxicity and induce mitochondrial dependent apoptosis. These findings demonstrate that cationic AuNTs with TPP can selectively target breast cancer cells in the presence of 5-ALA and PDT.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Xuemei Shen, Jia Tang, Rui Jiang, Xiaogang Wang, Zhaoxin Yang, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Summary: This study identified a novel circRILPL1 that acts as a sponge for miR-145 to regulate the IGF1R gene, promoting myoblast growth.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Tao Shen, Wei Wang, Wolong Zhou, Ilsa Coleman, Qinbo Cai, Bingning Dong, Michael M. Ittmann, Chad J. Creighton, Yingnan Bian, Yanling Meng, David R. Rowley, Peter S. Nelson, David D. Moore, Feng Yang
Summary: The study revealed that MAPK4 promotes prostate cancer growth and castration resistance by activating GATA2/AR and AKT pathways. Activation of both GATA2/AR and AKT is necessary for MAPK4 tumor-promoting activity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Jian Zhuo, Jianjun Han, Yanchun Zhao, Ruiying Hao, Chong Shen, He Li, Luxian Dai, Ankang Sheng, Hanyu Yao, Xiaohong Yang, Weiguang Liu
Summary: The study provides insights into the role of RAB10 in breast cancer, showing its association with prognosis and its impact on cell proliferation, invasion, and immune cell infiltration. RAB10 may serve as a potential biomarker or molecular target for breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Bianqin Guo, Xiaopeng Xiong, Sumati Hasani, Yang-An Wen, Austin T. Li, Rebecca Martinez, Ashley T. Skaggs, Tianyan Gao
Summary: Aberrant activation of endoplasmic reticulum (ER) stress by intrinsic and extrinsic factors contributes to tumor initiation and chemoresistance in various cancers. Downregulation of PHLPP in colon cancer cells, induced by ER stress, upregulates autophagy-associated genes through the eIF2 alpha/ATF4 signaling axis, resulting in increased resistance to chemotherapy.
CELL DEATH & DISEASE
(2021)