Article
Pharmacology & Pharmacy
Han Hong, Zhengkang Jin, Tao Qian, Xiaoyong Xu, Xiang Zhu, Qiang Fei, Jiamei Yang, Chengjun Sui, Minhui Xu
Summary: Falcarindiol (FAD) inhibits the proliferation and DNA repair of hepatocellular carcinoma (HCC) cells, promotes apoptosis, and enhances the chemosensitivity of cisplatin (DDP). FAD also exerts anti-tumor effects by dampening the STAT3/PTTG1 pathway in HCC cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yi-Sheng Liu, Yu-Chun Chang, Wei-Wen Kuo, Ming-Cheng Chen, Tso-Fu Wang, Tung-Sheng Chen, Yueh-Min Lin, Chi-Cheng Li, Po-Hsiang Liao, Chih-Yang Huang
Summary: This study reveals the molecular mechanism of the important role of calreticulin in liver cancer cells through the establishment of drug-resistant cells using histone deacetylase inhibitors.
Article
Chemistry, Medicinal
Meng Jin, Li Kong, Ying Han, Sen Zhang
Summary: The study showed that curcumin can enhance the chemosensitivity of HCC cells to 5-Fu by promoting apoptosis, arresting the cell cycle at G2/M phase, and blocking the PI3K/AKT/mTOR signaling pathway. In vivo, curcumin also significantly increased the sensitivity of H22 cells to 5-Fu and inhibited tumor growth, with gut microbiota playing a key role in its effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Xin Zhou, Jianzhu Luo, Haixiang Xie, Zhongliu Wei, Tianman Li, Junqi Liu, Xiwen Liao, Guangzhi Zhu, Tao Peng
Summary: This study found that in hepatocellular carcinoma (HCC), MCM2 enhances the stemness of tumor cells by regulating the Hippo signaling pathway, while inhibition of MCM2 can effectively reverse resistance to sorafenib.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Hui Li, Yujuan Liu, Wei Jiang, Junhui Xue, Yuning Cheng, Jiyin Wang, Ruixiang Yang, Xiaowei Zhang
Summary: Icaritin inhibits AFP expression in liver cancer cells at both mRNA and protein levels. It targets AFP as the downstream gene of the p53 transcription factor, improving p53 stability by inhibiting its ubiquitination degradation through Mdm2/p53 pathways. This ultimately leads to the inhibition of cellular proliferation and promotion of cellular apoptosis in hepatocellular carcinoma.
Article
Cell Biology
Honglei Cui, Danfeng Guo, Xiaodan Zhang, Yaohua Zhu, Zhihui Wang, Yang Jin, Wenzhi Guo, Shuijun Zhang
Summary: The study revealed that ENO3 is significantly down-regulated in HCC patients and is related to poor prognosis. Overexpression of ENO3 inhibited the proliferative, migratory, and invasive abilities of HCC cells, while also inhibiting the EMT process. ENO3 further modulated the transcription of genes associated with proliferation and metastasis capacity of HCC cells by suppressing the Wnt/beta-catenin signal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Rui Shi, Zirong Liu
Summary: RPL15 plays crucial roles in the progression and metastasis of hepatocellular carcinoma (HCC), serving as a promising candidate for targeted therapies.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Yonggang Ren, Jing Yang, Zhiran Ding, Menghua Zheng, Lu Qiu, Aifa Tang, Dandan Huang
Summary: Nuclear factor erythroid 2-like 3 (NFE2L3) is a transcription factor that promotes hepatocellular carcinoma (HCC) cell proliferation by directly inducing the expression of proteasome and interferon-stimulated gene 15 (ISG15), resulting in proteasome-dependent degradation of ISGylated p53. This post-translational modification destabilizes p53 and facilitates HCC cell growth. The findings suggest that NFE2L3 may serve as a new target for the clinical treatment of HCC.
Article
Oncology
Lin Che, Jia-Shen Wu, Ze-Bang Du, Yu-Qiao He, Lei Yang, Jin-Xian Lin, Zhao Lei, Xiao-Xuan Chen, Dong-Bei Guo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Summary: Translation: New therapeutic strategies are needed to improve the anti-cancer effect for hepatocellular carcinoma (HCC). This study explores the involvement of mitochondrial translocation of cyclooxygenase-2 (COX-2) in mitochondrial dynamics and sensitization of HCC cells to anti-tumor therapy. The findings suggest that targeting mitochondrial COX-2 could be a potential therapeutic approach for HCC and other cancers with high expression of COX-2.
Article
Plant Sciences
Zhili Zeng, Weichi Jiang, Jun Kan, Dong Zhang, Rui Li, Fan He, Yuechen Hu, Xiushen Li, Enxin Zhang, Zebiao Cao
Summary: This study aims to explore the regulatory effect of E2F2 on the p53 signaling pathway and reveal the role and mechanism of STR in promoting cell apoptosis via the E2F2-p53 signaling pathway in HCC. The results showed that E2F2 overexpression significantly inhibited apoptosis and the p53 pathway in HepG2 cells, whereas E2F2-silenced HepG2 cells showed the reverse. STR could remarkably inhibit the growth of xenografts, promote the apoptosis of hepatoma cells, downregulate E2F2, and activate the p53-dependent mitochondrial apoptotic pathway in vivo.
Article
Medicine, Research & Experimental
Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen
Summary: The study demonstrated that eIF6 expression was significantly increased in HCC and correlated with its pathological progression. eIF6 served as a new diagnostic biomarker and an independent risk factor for OS in HCC patients. Functional studies showed that deletion of eIF6 exhibited tumor-suppressor activity in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jingyi Chen, Fangxin Zhao, Hongxin Yang, Jianxun Wen, Ying Tang, Fang Wan, Xuan Zhang, Jianqiang Wu
Summary: This study reveals that Gentian violet (GV) induces ferroptosis and apoptosis, inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma (HCC). It also attenuates HCC growth in vivo. The findings demonstrate a GV-Hep27-MDM2-p53 signaling cascade that regulates ferroptosis and apoptosis, providing insights into the anti-tumor function of GV and potential therapeutic strategies for HCC treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Immunology
Hanren Chen, Shulian Jiang, Peng Zhang, Zhongyu Ren, Jian Wen
Summary: Exosomes as vehicles synergized with PIONs@E6 can enhance immunity against HCC by promoting M1 macrophages polarization. The PIONs-contained exosomes showed dose-dependent promotion of M1 macrophages polarization, higher ROS levels in macrophages, and significant inhibition of tumor growth in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Dawei Yuan, Rulan Ma, Tuanhe Sun, Kun Zhu, Chengxue Dang, Haixia Ye, Kang Li
Summary: The high expression of RSPH14 in hepatocellular carcinoma (HCC) is associated with poor prognosis. Knockdown of RSPH14 can inhibit cell proliferation, migration, and invasion, and promote apoptosis of HCC cells by inhibiting the expression of RelA. RSPH14 may be a potential new treatment target for HCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Pan Xu, Aoran Luo, Chuan Xiong, Hong Ren, Liang Yan, Qiang Luo
Summary: This study verified the role of SCUBE3 in hepatocellular carcinoma (HCC) progression and demonstrated that SCUBE3 promotes HCC cell proliferation by regulating CCNE1. The study also identified alterations in signaling pathways associated with SCUBE3, including the TGF beta signaling pathway and the PI3K/AKT signaling pathway.
CANCER CELL INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Jingkun Yuan, Peigang He, Dechang Jia, Chao Yang, Yao Zhang, Shu Yan, Zhihua Yang, Xiaoming Duan, Shengjin Wang, Yu Zhou
CERAMICS INTERNATIONAL
(2016)