Journal
CANCER SCIENCE
Volume 102, Issue 7, Pages 1418-1423Publisher
WILEY
DOI: 10.1111/j.1349-7006.2011.01935.x
Keywords
-
Categories
Funding
- Grants-in-Aid for Scientific Research [21590440] Funding Source: KAKEN
Ask authors/readers for more resources
Nucleostemin (NS) has been reported as essential for stem and cancer cell proliferation. To investigate the significance of NS in oral squamous cell carcinomas (OSCCs), we examined NS expression in neoplastic tissue of the tongue and in OSCC cell lines. Nucleostemin expression in the histological samples showed positive correlation with Ki-67 expression. Furthermore, NS expression was associated with cellular proliferation in OSCC cell lines using siRNA, which upregulated p27, a cyclin-dependent kinase inhibitor. Regarding OSCC differentiation, NS expression did not influence cornification or oral epithelial differentiation markers such as involucrin and cytokeratin19. Thus, NS is widely expressed in normal and neoplastic oral epithelial tissues, and is likely a marker of proliferation. (Cancer Sci 2011; 102: 1418-1423)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available