Journal
CANCER SCIENCE
Volume 102, Issue 4, Pages 706-712Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1349-7006.2011.01868.x
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Funding
- National Natural Science Foundation of China [30972680, 30771952]
- Program for New Century Excellent Talents in University [NCET-07-0410]
- State Key Laboratory for Molecular Virology and Genetic Engineering [2010KF06]
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To investigate the correlation between normalization of T cell receptor (TCR) repertoire and remission of advanced colorectal cancer. Forty-one patients were randomly assigned to receive either folinic acid/fluorouracil/irinotecan alone (n = 20) or folinic acid/fluorouracil/irinotecan in combination with recombinant human endostatin (n = 21). Efficacy and toxicity were evaluated, and changes in TCR repertoire diversity were assessed by detecting the spectratypes of TCR complementarity-determining region three before and after several cycles of therapy. A scoring system was used to quantify changes in the TCR repertoire over time. The results demonstrated that the TCR repertoire exhibited a higher degree of normalization among patients undergoing remission relative to patients experiencing tumor progression. The results of the current study showed a positive correlation between TCR repertoire normalization and remission of colorectal cancer, suggesting that dynamic monitoring of TCR repertoire diversity may have potential prognostic value in the clinical setting. (Cancer Sci 2011; 102: 706-712)
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