Article
Chemistry, Inorganic & Nuclear
Sindhu Kondath, Rama Rajaram, Rajaram Anantanarayanan
Summary: Curcumin nanotechnologies have been shown to enhance the therapeutic efficacy of curcumin against breast cancer cells. The synthesized cAuNPs exhibit a synergistic effect between the gold core and curcumin, triggering apoptosis through the generation of reactive oxygen species and releasing pro-apoptotic proteins. These findings suggest the potential of cAuNPs as a promising chemotherapeutic drug candidate.
INORGANIC AND NANO-METAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Ting Wang, Jingjing Dong, Xu Yuan, Haotian Wen, Linguangjin Wu, Jianwen Liu, Hua Sui, Wanli Deng
Summary: C49 in combination with DOX restores DOX sensitivity in MCF-7/DOX cells by inhibiting P-gp protein expression. C49 inhibits the growth of MCF-7 and MCF-7/DOX cells and increases cellular accumulation of DOX in MCF-7/DOX cells, leading to inhibition of cell proliferation and promotion of apoptosis. Meanwhile, C49 significantly enhances the anticancer efficacy of DOX in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Wei Wei, Xiao-Man Fan, Shao-Hui Jia, Xi-Ping Zhang, Zhao Zhang, Xue-Jun Zhang, Jiu-Xun Zhang, Ye-Wang Zhang
Summary: Sea cucumbers are marine echinoderm animals that contain valuable nutrients and medicinal compounds with promising biological and pharmacological properties. In this study, the sea cucumber intestinal peptide (SCIP) extracted from sea cucumber intestines showed potential anti-cancer effects by inhibiting tumor cell growth and promoting apoptosis, possibly via the inhibition of the PI3K/AKT signal transduction pathway.
FRONTIERS IN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Hanaa Hegazy, Maha M. Amin, Walid Fayad, Mohamed Y. Zakaria
Summary: The goal of this study was to design bilosomes coated with D-alpha-tocopheryl polyethylene glycol succinate (TPGS) as an oral delivery platform to enhance the effectiveness and permeability of Curcumin (CUR) for cancer treatment. Through factorial analysis, the optimal formulation was selected based on particle size, zeta potential, and entrapment efficiency, and further coated with TPGS. The results showed that the TPGS-coated bilosomes exhibited increased permeation and cellular uptake of CUR, leading to significant reduction in IC50 value against multidrug resistant tumors.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Saeideh Jafarinejad-Farsangi, Mahnaz Sadat Hashemi, Seyede Elmira Yazdi Rouholamini, Sdigheh Gharbi, Zeinab Ansari-Asl, Elham Jafari, Amin Shiralizadeh Dezfuli, Mariam Shahrokhi-Farjah
Summary: The use of graphene nanosheets loaded with curcumin shows enhanced anti-tumor activity in breast cancer cells, with graphene oxide and quantum dots as suitable carriers. Different responses of different cells to these nanoparticles suggest a need for further investigation into the underlying molecular mechanisms.
BIOMEDICAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ahreum Kwon, Hyun Wook Chae, Woo Jung Lee, JungHyun Kim, Ye Jin Kim, Jungmin Ahn, Youngman Oh, Ho-Seong Kim
Summary: This study aimed to demonstrate that IGFBP-3 induces cellular senescence and inhibits cell proliferation in MCF-7 breast cancer cells by suppressing telomerase activity. The results showed that IGFBP-3 induction led to loss of cell viability, increased percentage of non-cycling cells, morphological alterations associated with senescence, and decreased telomerase activity. These findings suggest that IGFBP-3 is a negative regulator of MCF-7 breast cancer cell growth through senescence induction and telomerase suppression.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Rija Abaid, Maria Malik, Muhammad Aamir Iqbal, Mariam Malik, Zubeda Shahwani, Taha Zaid Ali, Kareem Morsy, Rey Y. Capangpangan, Arnold C. Alguno, Jeong Ryeol Choi
Summary: The unique consequence of green synthesis is the release of chemicals from the mediator plant that act as reducing and stabilizing agents. In this study, silver nanoparticles were synthesized using the fruit pulp and leaf essences of Cassia fistula via green synthesis. The nanoparticles were formed through reduction caused by the reaction between plant essences and the precursor solution. The resulting biosynthesized silver nanoparticles were analyzed for their structure, optical properties, and crystalline behavior using scanning electron microscopy, UV-vis spectroscopy, and X-ray diffraction techniques. The silver nanoparticles exhibited absorption peaks at 401 and 397 nm, corresponding to optical energy gaps of 2.12 and 2.58 eV, and had spherical shapes with diameters ranging from 12-20 and 50-80 nm for the fruit and leaf extracts, respectively. These silver nanoparticles, along with the green synthesis technique, have various applications in the biomedical field, particularly as strong anti-tumor agents for MCF-7 breast cancer cell lines in order to inhibit cell growth rate based on their concentrations.
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Article
Multidisciplinary Sciences
Aubery Henry, Marine Mauperin, Jerome Devy, Stephane Dedieu, Lise Chazee, Cathy Hachet, Christine Terryn, Laurent Duca, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hassan El Btaouri
Summary: Multidrug resistance (MDR) is a common challenge in cancer chemotherapy, and it is often caused by the overexpression of membrane transport proteins such as P-gp. This study investigated the involvement of LRP-1 in the expression and subcellular redistribution of P-gp, and its potential role in P-gp-mediated MDR. The results showed that LRP-1 blockade reduced lysosomes density and the levels of LAMP-1 and P-gp, leading to the restoration of drug sensitivity in MDR cells.
Article
Chemistry, Multidisciplinary
Syed Farooq Adil, Mohammed Rafi Shaik, Fahd A. Nasr, Ali S. Alqahtani, Mohammad Z. Ahmed, Wajhul Qamar, Mufsir Kuniyil, Adibah Almutairi, Abdulrahman Alwarthan, Mohammed Rafiq H. Siddiqui, Mohammad Rafe Hatshan, Mujeeb Khan
Summary: The study revealed that functionalized graphene nanocomposites have enhanced anticancer properties against human breast cancer cells, demonstrating improved physical stability and dispersibility.
Article
Pharmacology & Pharmacy
Xing Chang, Zi Liu, Simeng Cao, Jiang Bian, Dayong Zheng, Nuo Wang, Qi Guan, Yingliang Wu, Weige Zhang, Zengqiang Li, Daiying Zuo
Summary: In this study, it was found that 2-Methoxy-5 ((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) could inhibit BCRP function, block cell cycle, and mediate apoptosis through PI3K-Akt-MDM2 pathway inhibition, thus overcoming multidrug resistance in adriamycin-resistant MCF-7 cells.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Oncology
Shailima Rampogu, Seong Min Kim, Baji Shaik, Gihwan Lee, Ju Hyun Kim, Gon Sup Kim, Keun Woo Lee, Myeong Ok Kim
Summary: The study successfully designed and synthesized three compounds, showing anticancer properties in breast cancer cell lines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jun Li, Song-He Wang, Yang-Ting Liu, Qin Zhang, Guang-Zhou Zhou
Summary: EF-24 exhibited antiproliferative and antimigratory activities on MCF-7 cells. It inhibited autophagic flux, induced apoptosis, and showed crosstalk between autophagy and apoptosis in breast cancer cells. These findings provide a solid foundation for further investigation of EF-24's potential anticancer activity on MCF-7 cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biophysics
Sen Liu, Haojun Liang, Linwen Lv, Fan Hu, Qiuyang Liu, Yujiao Wang, Junyu Zhu, Ziteng Chen, Jiacheng Li, Zhijie Wang, Ya-nan Chang, Juan Li, Xiancai Ma, Kui Chen, Gengmei Xing
Summary: This study found that the polyhydroxylated fullerenol nanoparticle (FNP) can induce the exposure of calreticulin (CRT) on the surface of MCF-7 cells by redistributing CRT from the endoplasmic reticulum (ER). The combination of FNP and anti-CD47 monoclonal antibody (mAb) enhances macrophage-mediated phagocytosis of cancer cells. In vivo experiments also confirmed the regulatory effect of FNP on the progression of MCF-7 cancer stem-like cells (CSCs). These findings expand the application of FNP in tumor therapy with anti-CD47 mAb and suggest the use of 3D culture as a screening tool for nanomedicine.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
R. Suriya, G. S. Lekshmi, T. S. Anirudhan
Summary: This study focused on a novel combinatorial approach involving the use of Hyaluronic acid (HA) targeted Soy protein (SOY) capped Aminated Mesoporous Silica (AMSN) for the co-delivery of curcumin (CUR) and doxorubicin (DOX) in colon cancer treatment. The drug carrier was modified and characterized, and the dual drug delivery system (DDDS) showed high drug loading efficiency and pH-dependent release. The DDDS demonstrated effective anticancer activity in DLD-1 human colon cancer cell lines and no toxicity in cardiac cells, making it a promising candidate for drug delivery applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
