Article
Oncology
Sandra Schwarz, Johanna Schmitz, Markus W. Loeffler, Michael Ghosh, Hans-Georg Rammensee, Evgenia Olshvang, Marvin Markel, Nadine Mockel-Tenbrinck, Andrzej Dzionek, Susann Krake, Basak Arslan, Kapil Dev Kampe, Anne Wendt, Peter Bauer, Christina S. Mullins, Andreas Schlosser, Michael Linnebacher
Summary: This study demonstrates the presence of mutated neoantigens and cryptic peptides on HLA class I molecules in colorectal cancer patients. Stimulation with these peptides significantly enhances tumor cell recognition by Tc. Additionally, expanding the target scope for cancer vaccines through the use of cryptic peptides is emphasized due to the limited number of neoantigenic peptides identified by HLA ligandome analysis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Xiaonan Wang, Shunlin Li, Siqi Yan, Yuanye Shan, Xiao Wang, Zhai Jingbo, Yuanyuan Wang, Fengping Shan, Noreen Griffin, Xun Sun
Summary: Evidence suggests that methionine enkephalin (MENK), an opioid peptide, can inhibit the progression of colorectal cancer by remodeling the tumor immune microenvironment and increasing the immunogenicity of cancer cells. MENK down-regulates oncogenes and inflammatory cytokines while up-regulating immune mediators, leading to enhanced anti-tumor immune responses. It also promotes the activation of effector T cells and reduces the expression of immune checkpoints. Furthermore, MENK binds to the Mu opioid receptor (OGFr), and blocking OGFr activity reverses the inhibitory effects of MENK on tumor growth.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Ken Ofusa, Tsunekazu Mizushima, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii
Summary: This study found that the number of CD103(+)/CD8(+) tumor-infiltrating lymphocytes (TILs) is a favorable prognostic factor in colorectal cancer (CRC). Additionally, they identified the expression of ZNF683 as a candidate marker for cancer-specific tissue-resident memory T (Trm) cells. The activation of Trm cells in tumors involves IFN-gamma and TCR signaling, as well as ZNF683 expression, which could be promising targets for cancer immunity regulation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Elena Bruni, Matteo Maria Cimino, Matteo Donadon, Roberta Carriero, Sara Terzoli, Rocco Piazza, Sarina Ravens, Immo Prinz, Valentina Cazzetta, Paolo Marzano, Paolo Kunderfranco, Clelia Peano, Cristiana Soldani, Barbara Franceschini, Federico Simone Colombo, Cecilia Garlanda, Alberto Mantovani, Guido Torzilli, Joanna Mikulak, Domenico Mavilio
Summary: V delta 1 CD69(+) TILs represent a major subset of tumor-infiltrating lymphocytes in CLM, showing significant enrichment in peritumoral compartment and correlation with patient clinical outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Alessia Potenza, Chiara Balestrieri, Martina Spiga, Luca Albarello, Federica Pedica, Francesco Manfredi, Beatrice Claudia Cianciotti, Claudia De Lalla, Oronza A. Botrugno, Cristina Faccani, Lorena Stasi, Elena Tassi, Silvia Bonfiglio, Giulia Maria Scotti, Miriam Redegalli, Donatella Biancolini, Barbara Camisa, Elena Tiziano, Camilla Sirini, Monica Casucci, Chiara Iozzi, Danilo Abbati, Fabio Simeoni, Dejan Lazarevic, Ugo Elmore, Guido Fiorentini, Giulia Di Lullo, Giulia Casorati, Claudio Doglioni, Giovanni Tonon, Paolo Dellabona, Riccardo Rosati, Luca Aldrighetti, Eliana Ruggiero, Chiara Bonini
Summary: This study described the functional phenotype of T cells in primary and metastatic colorectal cancers using high-dimensional flow cytometry, RNA sequencing, and immunohistochemistry. It also developed CRC-specific engineered T cells using lentiviral vectors and CRISPR/Cas9 genome editing technologies.
Article
Oncology
Qiaoqi Sui, Dingxin Liu, Wu Jiang, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Yuan Li, Qingjian Ou, Binyi Xiao, Guochen Liu, Yihong Ling, Jiewei Chen, Zexian Liu, Zhixiang Zuo, Zhizhong Pan, Penghui Zhou, Jian Zheng, Pei-Rong Ding
Summary: DKK1 suppresses the antitumor immune reaction via the GSK3 beta/E2F1/T-bet axis in CD8+ T cells. Elevated serum DKK1 predicts poor tumor response to PD-1 blockade in dMMR/MSI CRCs, and DKK1 neutralization may restore sensitivity to PD-1 blockade.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Chong Zhang, Xiang-Yu Wang, Jie-Liang Zuo, Xue-Fu Wang, Xiao-Wen Feng, Bo Zhang, Yi-Tong Li, Chen-He Yi, Peng Zhang, Xiao-Chen Ma, Zhen-Mei Chen, Yue Ma, Jia-Hao Han, Bao-Rui Tao, Rui Zhang, Tian-Qi Wang, Li Tong, Wang Gu, Si-Yu Wang, Xiao-Fei Zheng, Wen-Kang Yuan, Zi-Jie Kan, Jie Fan, Xiang-Yang Hu, Jun Li, Chao Zhang, Jin-Hong Chen
Summary: Tertiary lymphoid structures (TLSs) in colorectal cancer liver metastases (CRCLM) are found to be associated with prognosis. The study analyzed data from 603 CRCLM patients and found that higher intratumor TLSs score is correlated with better prognosis, while higher peritumor TLSs score is correlated with poorer survival. Additionally, the study also found a correlation between immune cell composition within TLSs and TLSs score.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Chunyan Xu, Wenlu Zhang, Chengxia Liu
Summary: This study demonstrates that downregulation of FAK can inhibit the stem cell-like properties and migration of colorectal cancer cells partly through altered modulation of AKT phosphorylation.
Article
Multidisciplinary Sciences
Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Helene C. Descamps, Lenka Dohnalova, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss, Maayan Levy
Summary: The study identifies a metabolite signalling pathway that can be used as a strategy for preventing and treating colorectal cancer. Ketogenic diets and the ketone body BHB show a strong inhibitory effect on tumor growth by reducing cell proliferation. The findings suggest that BHB-triggered pathway could play a crucial role in regulating intestinal tumorigenesis.
Article
Biology
Chun-Yin Huang, Yu-Ting Weng, Po-Chen Li, Nien-Tsu Hsieh, Chun- Li, Hsiao-Sheng Liu, Ming-Fen Lee
Summary: The biologically active form of vitamin D, calcitriol, has been found to suppress cancer progression by reducing cell proliferation, increasing cell differentiation, and inhibiting angiogenesis. Research indicates that calcitriol can suppress glycolysis and cell growth in human colorectal cancer cells, leading to smaller tumors.
Editorial Material
Endocrinology & Metabolism
May Yin Lee, Wai Leong Tam
Summary: By using multimodal metabolomics technologies, Vande Voode et al. discovered tumor genotype-specific metabolic profiles and identified the methionine-cycle enzyme AHCY as a potential therapeutic target in colorectal cancer.
Review
Immunology
Hai Huang, Bing Liu, Na Qu, Shuling Zhang, Xueli Bai, Mike Handley, Fengping Shan
Summary: MENK, known as an opioid growth factor (OGF), plays important roles in regulating cell cycle, cell proliferation, and immune function. Researches have shown that OGF has potential applications in various autoimmune diseases and cancer treatments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Alexandros Lalos, Ali Tulek, Nadia Tosti, Robert Mechera, Alexander Wilhelm, Savas Soysal, Silvio Daester, Venkatesh Kancherla, Benjamin Weixler, Giulio C. Spagnoli, Serenella Eppenberger-Castori, Luigi Terracciano, Salvatore Piscuoglio, Markus von Flue, Alberto Posabella, Raoul A. Droeser
Summary: This study explores the combined prognostic significance of CD8+ T-cell density and SDF-1 expression in CRC, finding that tumors with high CD8+ T-cell infiltration and expression of SDF-1 have a more favorable 5-year overall survival rate. The combination of high CD8+ T-cell density and expression of SDF-1 represents an independent, favorable, prognostic condition in CRC, especially in patients with stage III disease.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Laura Tarnawski, Vladimir S. Shavva, Eric J. Kort, Zhengbing Zhuge, Ingrid Nilsson, Alessandro L. Gallina, David Martinez-Enguita, Benjamin Heller Sahlgren, Matthew Weiland, April S. Caravaca, Staffan Schmidt, Ping Chen, Katarina Abbas, Fu-Hua Wang, Osman Ahmed, Michael Eberhardson, Anna Farnert, Eddie Weitzberg, Mika Gustafsson, Jan Kehr, Stephen G. Malin, Henrik Hult, Mattias Carlstrom, Stefan Jovinge, Peder S. Olofsson
Summary: Endothelial dysfunction and impaired vasodilation are associated with adverse cardiovascular events. T lymphocytes expressing ChAT regulate vasodilation and play a role in the cholinergic antiinflammatory pathway. ChAT mRNA expression in human T cells is induced through the PI3K signaling cascade and regulated by REST-mediated methylation and up-regulation by GATA3. Functional experiments demonstrate that T cell-derived ACh promotes endothelial nitric oxide-synthase activity, vasorelaxation, and barrier integrity. Additionally, the frequency of ChAT(+)CD4(+) T cells in blood correlates with survival in patients with severe circulatory failure. These findings provide a mechanism for cholinergic immune regulation of vascular endothelial function in human inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye, Ping Lan
Summary: This study identifies IFI35 as a new biomarker that enhances the proliferation and function of CD8(+) T cells, as well as increases the efficacy of CAR-T cells against colorectal cancer cells.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)