Article
Environmental Sciences
Jian Meng, Juan Yang, Ting Pan, Xianjun Qu, Shuxiang Cui
Summary: Higher doses and prolonged exposure to zinc oxide nanoparticles (ZnO NPs) promote the malignant transformation of precancerous epithelial cells, exacerbating the severity of colonic inflammation and tumorigenesis in mice.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Juri Reimand, Michael D. Taylor, Sean E. Egan
Summary: The study identified 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in mouse models of breast cancer. These gCIS play a crucial role in tumorigenesis and tumor development, affecting various cancer pathways and processes.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Bing Li, Guoliang Zhang, Xuejie Xu
Summary: Objective: This study aimed to explore the impact of APC mutation on immunotherapy efficacy for colon cancer. The results showed that APC mutation was associated with worse immunotherapy outcome and inhibition of antitumor immunity. Therefore, APC mutation can be used as a negative biomarker to predict immunotherapy response.
BMC GASTROENTEROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Teng-Cheong Ha, Maike Stahlhut, Michael Rothe, Gabi Paul, Violetta Dziadek, Michael Morgan, Martijn Brugman, Boris Fehse, Olga Kustikova, Axel Schambach, Christopher Baum
Summary: Retroviral insertional mutagenesis is a risk in gene therapy and can be used to identify genes that enhance hematopoietic stem cell competitiveness. Studies have shown that a single insertion event may dysregulate distal and multiple genes. Furthermore, multiple genes within a common insertion site can have both positive and negative impacts on hematopoiesis.
HUMAN GENE THERAPY
(2021)
Article
Cell Biology
Zhongqi Cui, Guifeng Sun, Ramesh Bhandari, Jiayi Lu, Mengmei Zhang, Rajeev Bhandari, Fenyong Sun, Zhongchen Liu, Shasha Zhao
Summary: This study identified 226 dysregulated expression of glycolysis-related genes (DE-GRGs) in colon cancer patients and constructed a prognostic model that accurately predicted overall survival rates. High-risk patients showed higher tumor mutation load and tumor stem cell index, with lower sensitivity to chemotherapy drugs. This multi-omics study provides insights into GRGs' role in colon cancer prognosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuzhu Cao, Keqin Lu, Yawen Xia, Yufei Wang, Aiyun Wang, Yang Zhao
Summary: Danshensu inhibits the progression of colon cancer by suppressing platelet activity and the TGF-beta/Smad signaling pathway, leading to reduced migration and chemoresistance of tumor cells and enhanced sensitivity to chemotherapy.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Pathology
Jae Woong Kim, Seong Won Moon, Ha Yoon Mo, Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Chang Hyeok Ann, Sug Hyung Lee
Summary: Microsatellite instability-high (MSI-H) colorectal cancer (CRC) is characterized by increased mutation accumulation in repetitive DNA sequences due to defects in mismatch repair genes. This study found frameshift mutations in candidate tumor suppressor genes (TSGs) RGS2, HNF1A, HNF1B, CAPN12, RCBTB2, ATE1, PKNOX1, and USP19 in MSI-H CRCs, but not in microsatellite stable (MSS) CRCs. Protein expression loss of RGS2, HNF1A, and CAPN12 was also observed in a subgroup of CRCs. These alterations in TSGs may play a role in CRC development, and further research is needed to understand the underlying mechanisms and consequences.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Gastroenterology & Hepatology
Xiangren Jin, Yang Liu, Wei Yan, Shang Shi, Lujia Liu, Baiqiang Lin, Xiao Guo, Ting Cai, Yunwei Wei
Summary: This study found a close association between colon anastomotic leak (CAL) and the gut microbiota profile in patients with colorectal cancer (CRC). Using an experimental model, it was demonstrated that fecal microbiota from patients without CAL (nCAL) can promote anastomotic healing. The study also identified the role of TGF-beta/Smad-induced epithelial-mesenchymal transition (EMT) in this process.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Plant Sciences
Sruthy Maria Augustine, Anoop Vadakan Cherian, Kerstin Seiling, Stefano Di Fiore, Nicole Raven, Ulrich Commandeur, Stefan Schillberg
Summary: The study introduced a new technique for DNA-free genome editing in plants by using pulsed laser to generate cavitation bubbles for efficient transfection of walled cells. By targeting endogenous genes PDS and ADF in tobacco, genome-edited plants were produced with high efficiency. The physiological, cellular, and molecular effects of ADF mutations in T2 mutant plants under drought and salinity stress suggest that ADF acts as a key regulator of osmotic stress tolerance in plants.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Biology
Herman A. Dierick, Yehuda Ben-Shahar, Baranidharan Raman, Fabrizio Gabbiani
Summary: The development of genetically encoded tools for recording and manipulating neurons has greatly enhanced our understanding of how neuronal activity influences behavior, especially in the realm of insect neuroethology. These tools have significant implications for both basic and translational research, with potential for future development of universally applicable, modular, and user-friendly genetic toolkits.
CURRENT OPINION IN INSECT SCIENCE
(2021)
Article
Oncology
Xiaoyang Zhang, Hui Wang, Miao Yu, Kun Ma, Li Ning
Summary: Inhibition of autophagy in colon cancer cells enhances cell migration and invasion, and promotes epithelial-mesenchymal transition (EMT). This finding suggests that the inhibition of autophagy may have adverse effects in the treatment of colon cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Timothy W. Robison, Robert H. Heflich, Mugimane G. Manjanatha, Rosalie Elespuru, Aisar Atrakchi, Nan Mei, Wei Ding
Summary: The recommendations made by Kirkland et al. propose using in vivo comet and transgenic rodent gene mutation assays to screen for in vivo mutagenicity. The in vivo follow-up for an in vitro bacterial mutation-positive drug should be based upon evaluating a similar endpoint (i.e., mutagenicity) to determine if the findings of in vitro gene mutation correlate with in vivo gene mutation. The most scientifically appropriate in vivo assays would be the TGR mutation assay or, in some circumstances, the in vivo Pig-a assay.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2021)
Article
Physiology
B. Zhu, Q. -Q. Zhan, Q. -Y. Liu, X. Yang, Y. -H. Ge, G. -Y. Ding, S. Guo, W. -G. Xu
Summary: This study investigated the effect of NRP-1 silencing on TGF-beta 1-mediated EMT, proliferation, and migration of colon cancer cells. The results showed that silencing NRP-1 partially reversed EMT, reduced cell proliferation, and slowed migration ability.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Oncology
Sumimasa Arimura, Akane Inoue-Yamauchi, Kotoe Katayama, Tatsuo Kanno, Hiroki Jozawa, Seiya Imoto, Yuji Yamanashi
Summary: The fundamental difference between benign and malignant tumors lies in their invasive ability. The study found that the loss of the Dok-3 tumor suppressor gene led to malignant progression in a benign tumor model. However, this transformation was caused by a mechanism outside of the tumor cells.
CANCER RESEARCH COMMUNICATIONS
(2022)
