Review
Immunology
Kenny Misael Calvillo-Rodriguez, Helen Yarimet Lorenzo-Anota, Cristina Rodriguez-Padilla, Ana Carolina Martinez-Torres, Daniel Scott-Algara
Summary: Cancer immunotherapies can induce immunogenic cell death (ICD) in cancer cells, triggering innate and adaptive immune responses for sustained anticancer efficacy and antitumour immune memory. Understanding how ICD is triggered enhances our knowledge of these therapies and their potential for combination strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pei Tong, Avneesh Gautam, Ian W. Windsor, Meghan Travers, Yuezhou Chen, Nicholas Garcia, Noah B. Whiteman, Lindsay G. A. McKay, Nadia Storm, Lauren E. Malsick, Anna N. Honko, Felipe J. N. Lelis, Shaghayegh Habibi, Simon Jenni, Yongfei Cai, Linda J. Rennick, W. Paul Duprex, Kevin R. McCarthy, Christy L. Lavine, Teng Zuo, Junrui Lin, Adam Zuiani, Jared Feldman, Elizabeth A. MacDonald, Blake M. Hauser, Anthony Griffths, Michael S. Seaman, Aaron G. Schmidt, Bing Chen, Donna Neuberg, Goran Bajic, Stephen C. Harrison, Duane R. Wesemann
Summary: Memory B cell reserves can produce protective antibodies against SARS-CoV-2, but the impact on variants is unclear. Studying antibodies from convalescent individuals revealed seven major antibody competition groups, important for neutralizing the virus.
Article
Multidisciplinary Sciences
Roarke A. Kamber, Yoko Nishiga, Bhek Morton, Allison M. Banuelos, Amira A. Barkal, Felipe Vences-Catalan, Mingxin Gu, Daniel Fernandez, Jose A. Seoane, David Yao, Katherine Liu, Sijie Lin, Kaitlyn Spees, Christina Curtis, Livnat Jerby-Arnon, Irving L. Weissman, Julien Sage, Michael C. Bassik
Summary: This study developed a platform for unbiased identification of factors that impede antibody-dependent cellular phagocytosis (ADCP) in cancer cells, revealing the important roles of the enzyme APMAP and the G-protein-coupled receptor GPR84 in this process. This helps to expand our knowledge of the mechanisms governing cancer resistance to macrophage phagocytosis.
Review
Immunology
Aalia N. Khan, Ambalika Chowdhury, Atharva Karulkar, Ankesh Kumar Jaiswal, Ankit Banik, Sweety Asija, Rahul Purwar
Summary: CAR-T therapy has shown remarkable success in treating cancers and autoimmune diseases, but its immunogenicity may affect efficacy. The six FDA-approved CAR-T products derived from non-human origin scFv structures can induce immune responses, reducing the therapeutic effect of CAR-T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jenny Jin, Kenji Schorpp, Daniel Samaga, Kristian Unger, Kamyar Hadian, Brent R. Stockwell
Summary: A machine learning approach combined with staining techniques was developed to unbiasedly classify different cell death mechanisms based on specific cell features, providing a novel analytic framework.
ACS CHEMICAL BIOLOGY
(2022)
Review
Immunology
Alessandro Sette, Erica Ollmann Saphire
Summary: Investing in research to uncover mechanisms of broad-based immunity and developing vaccines that elicit both broadly protective antibodies and T cells is crucial to mitigate the impact of the next viral pandemic.
Article
Oncology
Darren C. Phillips, Fritz G. Buchanan, Dong Cheng, Larry R. Solomon, Yu Xiao, John Xue, Stephen K. Tahir, Morey L. Smith, Haichao Zhang, Deborah Widomski, Vivek C. Abraham, Nan Xu, Zhihong Liu, Li Zhou, Enrico DiGiammarino, Xin Lu, Nandini Rudra-Ganguly, Bruce Trela, Susan E. Morgan-Lappe
Summary: This study highlights the activity of a hexavalent TRAIL-receptor agonistic fusion protein in preclinical models of solid tumors, distinguishing it mechanistically from other TRAIL-based therapeutics.
Article
Agriculture, Dairy & Animal Science
Shuangjiang He, Huining Zhang, Shi Yin, Xiaoli Hao, Yi Yang, Shaobin Shang
Summary: This study discovered the presence of interleukin-9 receptor alpha chain (IL-9Ra) in birds, which plays important roles in allergy, inflammation, infection, and tumor immunity. The chicken IL-9Ra (chIL-9Ra) was cloned and its tissue distribution and expression form were characterized. Monoclonal antibodies against chIL-9Ra were generated and used to detect its expression on chicken splenocytes. This study provides important immunological tools for further investigation of the roles of chIL-9 in diseases and immunity.
Review
Biochemical Research Methods
Bryan Dransart, Houman Dehghani, Alison Moore
Summary: Allogeneic chimeric antigen-receptor T-cell processes involve large-scale cultures and novel processing steps, starting with donor-derived peripheral blood mononuclear cells and generating products for hundreds of patients. The safety considerations are diverse and unique, and the use of regulations and quality design principles is important in ensuring process safety.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemical Research Methods
Bryan Dransart, Houman Dehghani, Alison Moore
Summary: Allogeneic chimeric antigen-receptor T-cell process flows involve traditional and novel processing steps, starting from donor-derived cells to generate batches for treating multiple patients. Diverse unit operation-process safety considerations need to be taken into account to ensure process safety.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Health Care Sciences & Services
Sean Harrop, Chathuri Abeyakoon, Carrie Van der Weyden, H. Miles Prince
Summary: T-cell lymphomas, rare and unsatisfactorily treated, have shown progress in targeted therapies due to advancements in understanding T-cell lymphogenesis pathways and identifying therapeutic targets. New treatments include antibody-based, small molecule inhibitors, and immune-based therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Microbiology
Alexandre Bezerra Conde Figueiredo, Fernanda L. Fonseca, Diogo Kuczera, Fernando de Paiva Conte, Marcia Arissawa, Marcio L. Rodrigues
Summary: Novel therapeutic approaches to combat fungal infections are urgently needed due to antifungal resistance and significant toxicity. Monoclonal antibodies targeting chitooligomers have shown potential in enhancing fungicidal capacity and controlling cryptococcal pathogenesis, making them valuable tools in the control of cryptococcosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Madison T. Jones, Samantha W. Manioci, Ashley E. Russell
Summary: Extracellular vesicles (EVs) are nano-sized lipid-membrane bound structures released from cells, which can act as intercellular communicators and non-invasive biomarkers. The study demonstrates the effective separation of EVs using techniques such as ultrafiltration and size exclusion chromatography (SEC).
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Nadya Panagides, Lucia F. Zacchi, Mitchell J. De Souza, Rodrigo A. Morales, Alexander Karnowski, Mark T. Liddament, Catherine M. Owczarek, Stephen M. Mahler, Con Panousis, Martina L. Jones, Christian Fercher
Summary: Monoclonal antibodies (mAbs) are highly successful and versatile protein-based pharmaceutical products used in the treatment of various pathological conditions. The quality and presentation format of the antigen play a crucial role in the selection outcomes of mAbs against membrane protein targets. Soluble presentation of a type I membrane protein is more advantageous in isolating functional mAbs with higher sequence diversity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shaojie Cui, Anchal Ghai, Yaqin Deng, Shili Li, Ruihui Zhang, Christopher Egbulefu, Guoshen Liang, Samuel Achilefu, Jin Ye
Summary: This study identifies hyperoxidized peroxiredoxin 3 (PRDX3) as a marker for ferroptosis and determines that ferroptosis is responsible for death of hepatocytes in mouse models of both alcoholic and nonalcoholic fatty liver diseases. The research highlights the importance of ferroptosis in pathophysiological conditions and opens up new possibilities for treating these liver diseases.
Article
Cell Biology
Hirotada Otsuka, Hideki Yagi, Yasuo Endo, Satoshi Soeta, Naoko Nonaka, Masanori Nakamura
CELL AND TISSUE RESEARCH
(2017)
Article
Immunology
Shiki Takamura, Hideki Yagi, Yoshiyuki Hakata, Chihiro Motozono, Sean R. McMaster, Tomoko Masumoto, Makoto Fujisawa, Tomomi Chikaishi, Junko Komeda, Jun Itoh, Miki Umemura, Ami Kyusai, Michio Tomura, Toshinori Nakayama, David L. Woodland, Jacob E. Kohlmeier, Masaaki Miyazawa
JOURNAL OF EXPERIMENTAL MEDICINE
(2016)
Article
Chemistry, Organic
Yoshihiro Suyama, Yusuke Higashino, Naonobu Tanaka, Yutaka Tatano, Hideki Yagi, Kazuyoshi Kawazoe, Kotaro Murakami, Shun-Lin Li, Han-Dong Sun, Yoshiki Kashiwada
TETRAHEDRON LETTERS
(2017)
Article
Oncology
Miyuki Ookura, Tatsuya Fujii, Hideki Yagi, Takuya Ogawa, Shinji Kishi, Naoko Hosono, Hiroko Shigemi, Takahiro Yamauchi, Takanori Ueda, Akira Yoshida
Article
Chemistry, Organic
Naonobu Tanaka, Yuyu Jia, Kanji Niwa, Kiyoshi Imabayashi, Yutaka Tatano, Hideki Yagi, Yoshiki Kashiwada
Article
Oncology
Takatsugu Ishimoto, Osamu Nagano, Toshifumi Yae, Mayumi Tamada, Takeshi Motohara, Hiroko Oshima, Masanobu Oshima, Tatsuya Ikeda, Rika Asaba, Hideki Yagi, Takashi Masuko, Takatsune Shimizu, Tomoki Ishikawa, Kazuharu Kai, Eri Takahashi, Yu Imamura, Yoshifumi Baba, Mitsuyo Ohmura, Makoto Suematsu, Hideo Baba, Hideyuki Saya
Article
Oncology
Kaori Hara, Shiho Ueda, Yoshiya Ohno, Toshiyuki Tanaka, Hideki Yagi, Shogo Okazaki, Rieko Kawahara, Takechi Masayuki, Takemi Enomoto, Yoshiyuki Hashimoto, Kazue Masuko, Takashi Masuko
Article
Oncology
Yuta Hara, Ryota Torii, Shiho Ueda, Erina Kurimoto, Eri Ueda, Hiroshi Okura, Yutaka Tatano, Hideki Yagi, Yoshiya Ohno, Toshiyuki Tanaka, Kazue Masuko, Takashi Masuko
Article
Cell Biology
Mayumi Hidaka, Masanori Nakamura, Yukari Ohmichi, Jun Itoh, Kenji Fukuzawa, Takashi Masuko, Hideki Yagi
CELLULAR IMMUNOLOGY
(2012)
Article
Immunology
Yasuhiro Maeda, Hideki Yagi, Kana Takemoto, Hiroyuki Utsumi, Atsushi Fukunari, Kunio Sugahara, Takashi Masuko, Kenji Chiba
INTERNATIONAL IMMUNOLOGY
(2014)
Article
Infectious Diseases
Yoshio Takesue, Takashi Ueda, Hiroshige Mikamo, Shigeto Oda, Shunji Takakura, Yuko Kitagawa, Shigeru Kohno
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Pharmacology & Pharmacy
Masayuki Takechi, Tetsuyuki Wada, Hideki Yagi, Takashi Masuko, Atsufumi Kawabata
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2015)
Article
Multidisciplinary Sciences
Kazue Masuko, Shogo Okazaki, Mayumi Satoh, Goh Tanaka, Tatsuya Ikeda, Ryota Torii, Eri Ueda, Takashi Nakano, Masaaki Danbayashi, Tomoyo Tsuruoka, Yoshiya Ohno, Hideki Yagi, Noritsugu Yabe, Hideaki Yoshida, Tomoyuki Tahara, Shiro Kataoka, Taichi Oshino, Takayuki Shindo, Shin-ichiro Niwa, Takatsugu Ishimoto, Hideo Baba, Yoshiyuki Hashimoto, Hideyuki Saya, Takashi Masuko
Review
Pharmacology & Pharmacy
Hideki Yagi, Takashi Masuko
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2013)
Review
Pharmacology & Pharmacy
Keiji Nishiwaki, Atsushi Kawase, Tetsuyuki Wada, Hideki Yagi, Naohito Kawasaki, Eiji Ito, Masahiro Iwaki
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2014)