Review
Biochemistry & Molecular Biology
Licen Li, Chu-Xia Deng, Qiang Chen
Summary: SRC-3, also known as AIB1, is a member of the SRC family and plays a crucial role in regulating the transcriptional activity of nuclear receptors and promoting cancer development. Understanding the mode of action of SRC-3 can provide insights for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lei Bao, Ashwani Kumar, Ming Zhu, Yan Peng, Chao Xing, Jennifer E. Wang, Yingfei Wang, Weibo Luo
Summary: SAP30 is an important protein in breast cancer, and its upregulation is associated with unfavorable prognosis. Research has shown that SAP30 promotes tumor growth and metastasis through mechanisms other than canonical gene silencing. Additionally, SAP30 enhances cell motility, angiogenesis, and lymphangiogenesis by interacting with other proteins, thereby driving breast cancer progression.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Zhaoyou Meng, Xiaoya Wang, Dongmei Zhang, Zhen Lan, Xiaoxia Cai, Chen Bian, Jiqiang Zhang
Summary: The effects of steroid hormones are mediated by their nuclear receptors. The p160 coactivator family interacts with nuclear receptors to enhance their transcriptional activities. SRC-1, predominantly localized in the central nervous system, is regulated by steroids and non-steroidal factors. It plays important roles in normal function and pathophysiology, but its mechanisms are not fully understood.
Article
Biochemistry & Molecular Biology
Vineet K. Maurya, Maria M. Szwarc, David M. Lonard, Ramakrishna Kommagani, San Pin Wu, Bert W. O'Malley, Francesco J. DeMayo, John P. Lydon
Summary: The role of steroid receptor coactivator-2 (SRC-2) in the implantation process and the development of uterine receptivity has been investigated. The study found that SRC-2 is essential for embryo attachment and adherence to the luminal epithelium. It also plays a role in the plasma membrane transformation (PMT) state required for uterine receptivity.
Article
Biochemistry & Molecular Biology
Bowen Yan, Jennifer Yang, Min Young Kim, Huacheng Luo, Nicholas Cesari, Tao Yang, John Strouboulis, Jiwang Zhang, Ross Hardison, Suming Huang, Yi Qiu
Summary: The activity of hematopoietic factor GATA-1 is modulated by acetylation and deacetylation processes mediated by HDAC1, allowing for chromatin binding and transcriptional regulation of erythroid/megakaryocyte commitment and differentiation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Bowen Yan, Jennifer Yang, Min Young Kim, Huacheng Luo, Nicholas Cesari, Tao Yang, John Strouboulis, Jiwang Zhang, Ross Hardison, Suming Huang, Yi Qiu
Summary: The activity of hematopoietic factor GATA-1 is modulated through acetylation and deacetylation processes mediated by p300/CBP and HDAC1/2 respectively. The deacetylation of GATA-1 is crucial for gene activation, chromatin binding, and the commitment and differentiation of erythroid/megakaryocyte cells. Mutations preventing GATA-1 deacetylation result in impaired erythroid differentiation and abnormalities in cell subpopulations and gene expression patterns in hematopoietic stem cells and progenitors.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sourav Roy, Tusar T. Saha, Jisu Ha, Roumik Banerjee, Emre Aksoy, Aditi Kulkarni, Alexander S. Raikhel
Summary: This study reveals the transcriptional regulatory networks during the egg maturation period and post-blood meal in female Aedes aegypti mosquitoes, as well as the negative transcriptional regulation mechanisms of genes by the steroid hormone 20-hydroxyecdysone (20E) through the ecdysone receptor (EcR). Different groups of genes show distinct expression profiles under high concentrations of 20E, with early genes being indirectly repressed through the classic 20E pathway and late mid-genes being directly repressed by EcR through a novel DNA element recruitment of Mi2 for chromatin condensation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Jianbing Hou, Yudong Liu, Pan Huang, Yutao Wang, Dakun Pei, Ruoyue Tan, Yundong Zhang, Hongjuan Cui
Summary: RANBP10 is overexpressed in GBM and correlated with poor patient survival; downregulation of RANBP10 significantly inhibits proliferation, migration, and tumor growth of GBM cells; RANBP10 promotes GBM progression by controlling the FBXW7-c-Myc axis.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Rebecca J. Watters, Kostas Verdelis, Peter C. Lucas, Shiming Jiang, Yuqing Chen, Feiqi Lu, Benjamin M. Martin, Lyuda Lukashova, Geoffrey Pecar, Alejandro Morales-Restrepo, Margaret Hankins, Li Zhu, Peter Mittwede, Ryan J. Hartmaier, Peter G. Alexander, George C. Tseng, Kurt R. Weiss, Deborah L. Galson, Adrian Lee, Brendan Lee, Steffi Oesterreich
Summary: The SNP P1272S in the SRC-1 gene affects estrogen receptor activity and is associated with the effect of SERMs on bone density, possibly promoting breast cancer bone metastasis.
Article
Cell Biology
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou
Summary: This study reveals that G protein-coupled receptor neurokinin-1 (NK1R) is significantly upregulated in lung cancer samples and is associated with advanced clinical stages and poor prognosis. NK1R co-expresses with epidermal growth factor receptor (EGFR) and interacts with it in tumor cells. Activation of NK1R promotes lung cancer cell proliferation and migration through EGFR signaling pathways. Inhibition of NK1R suppresses cell proliferation and migration, and knockdown of NK1R slows down tumor growth. The presence of a selective NK1R antagonist enhances the sensitivity of lung cancer cells to specific drugs.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Mingyue Ma, Na Wei, Jieren Yang, Tingting Ding, Anping Song, Lerong Chen, Shuguo Zheng, Huanhuan Jin
Summary: This study aimed to investigate the effect of Schisandrin B (Sch B) on activated hepatic stellate cells (HSCs) senescence in hepatic fibrosis and its underlying mechanism. The results showed that Sch B could alleviate hepatic fibrosis and promote the senescence of activated HSCs, possibly through the induction of NCOA4-mediated ferritinophagy to enhance the aging process.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Tessa M. Cacciottolo, Elana Henning, Julia M. Keogh, Pierre Bel Lassen, Katherine Lawler, Rebecca Bounds, Rachel Ahmed, Aliki Perdikari, Edson Mendes de Oliveira, Miriam Smith, Edmund M. Godfrey, Elspeth Johnson, Leanne Hodson, Karine Clement, Agatha A. van der Klaauw, I. Sadaf Farooqi
Summary: SRC-1 variant carriers exhibit hyperphagia in childhood, severe obesity, and clinical features of partial hormone resistance. The presence of adipose tissue fibrosis and hepatic fibrosis in young patients suggests that close monitoring for the early development of obesity-associated metabolic complications is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Xiuqun Zou, Li Ma, Yihong Zhang, Qun Zhang, Chu Xu, Dan Zhang, Yimin Chu, Jie Zhang, Mengying Li, Hui Zhang, Jiamin Wang, Chicheng Peng, Gang Wei, Yingjie Wu, Zhaoyuan Hou, Hao Jia
Summary: In this study, it was found that Snail, a transcriptional repressor, cooperates with GATA zinc finger protein p66β to activate gene transcription in breast cancer cells. Depletion of p66β reduces cell migration and lung metastasis. Snail directly binds to G-box elements in the promoters of genes induced by Snail and p66β enhances Snail's binding affinity, resulting in the transcription of Snail-induced genes.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Miaomiao Gong, Xun Wang, Lin Mu, Yueyue Wang, Jinjin Pan, Xiaocheng Yuan, Haoran Zhou, Jinshan Xing, Rui Wang, Jian Sun, Qiwang Liu, Xiya Zhang, Lin Wang, Yiying Chen, Yandong Pei, Shao Li, Liang Liu, Yongshun Zhao, Yuhui Yuan
Summary: This study reveals that SRC-1 promotes the stemness of GBM by activating the XIST/miR-152/KLF4 pathway, providing novel markers for diagnosis and therapy of GBM.
Article
Multidisciplinary Sciences
Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qing Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, Xiaoting Gu, Ting Xiao, Hui Huang, Shanshan Chen, Wen Ning, Guang Yang, Cheng Yang, Honggang Zhou
Summary: Our study demonstrates that PKM2 promotes fibrosis progression by interacting with Smad7 and enhancing TGF-beta 1 signaling. Increased expression of PKM2 in the lungs of mice with pulmonary fibrosis contributes to fibrosis development. The PKM2 tetramer enhances TGF-beta 1 signaling by directly binding with Smad7, making it a key factor in fibrosis progression.
Article
Food Science & Technology
Attia Fatima, Ruth M. Connaughton, Anna Weiser, Aoife M. Murphy, Colm O'Grada, Miriam Ryan, Lorraine Brennan, Peadar O'Gaora, Helen M. Roche
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Article
Oncology
Giulia Biffi, Tobiloba E. Oni, Benjamin Spielman, Yuan Hao, Ela Elyada, Youngkyu Park, Jonathan Preall, David A. Tuveson
Review
Endocrinology & Metabolism
Rachel Bleach, Marie McIlroy
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Oncology
Laura Creevey, Rachel Bleach, Stephen F. Madden, Sinead Toomey, Fiona T. Bane, Damir Vareslija, Arnold D. Hill, Leonie S. Young, Marie McIlroy
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Oncology
Ela Elyada, Mohan Bolisetty, Pasquale Laise, William F. Flynn, Elise T. Courtois, Richard A. Burkhart, Jonathan A. Teinor, Pascal Belleau, Giulia Biffi, Matthew S. Lucito, Santhosh Sivajothi, Todd D. Armstrong, Dannielle D. Engle, Kenneth H. Yu, Yuan Hao, Christopher L. Wolfgang, Youngkyu Park, Jonathan Preall, Elizabeth M. Jaffee, Andrea Califano, Paul Robson, David A. Tuveson
Article
Immunology
Tobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Yuan Hao, Claudia Tonelli, Tim D. D. Somerville, Astrid Deschenes, Pascal Belleau, Chang-il Hwang, Francisco J. Sanchez-Rivera, Hilary Cox, Erin Brosnan, Abhishek Doshi, Rebecca P. Lumia, Kimia Khaledi, Youngkyu Park, Lloyd C. Trotman, Scott W. Lowe, Alexander Krasnitz, Christopher R. Vakoc, David A. Tuveson
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Oncology
Nina G. Steele, Giulia Biffi, Samantha B. Kemp, Yaqing Zhang, Donovan Drouillard, LiJyun Syu, Yuan Hao, Tobiloba E. Oni, Erin Brosnan, Ela Elyada, Abhishek Doshi, Christa Hansma, Carlos Espinoza, Ahmed Abbas, Stephanie The, Valerie Irizarry-Negron, Christopher J. Halbrook, Nicole E. Franks, Megan T. Hoffman, Kristee Brown, Eileen S. Carpenter, Zeribe C. Nwosu, Craig Johnson, Fatima Lima, Michelle A. Anderson, Youngkyu Park, Howard C. Crawford, Costas A. Lyssiotis, Timothy L. Frankel, Arvind Rao, Filip Bednar, Andrzej A. Dlugosz, Jonathan B. Preall, David A. Tuveson, Benjamin L. Allen, Marina Pasca di Magliano
Summary: The study reveals that Hedgehog signaling is uniquely activated in fibroblasts in PDAC, with varying levels of elevation in myofibroblastic CAFs compared to inflammatory CAFs. Inhibition of the Hedgehog pathway slows tumor growth, alters the composition of CAF subtypes, and impacts immune cell infiltration, leading to increased immunosuppression.
CLINICAL CANCER RESEARCH
(2021)
Review
Cell Biology
Rachel Bleach, Mark Sherlock, Michael W. O'Reilly, Marie McIlroy
Summary: IGF signaling plays a crucial role in tumor growth, with complex interactions with sex hormones and endocrine-driven cancers. IGF-1 plays a compensatory role in ER and AR by enhancing hormonal responses, and dysregulated IGF signaling is associated with breast and prostate cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Yosi Gilad, Yossi Eliaz, Yang Yu, Adam M. Dean, San Jung Han, Li Qin, Bert W. O'Malley, David M. Lonard
Summary: SRC-3 is a key regulator in breast cancer tumorigenesis with its inhibitor SI-12 showing anti-proliferative activity in various cancer types. A genome-scale CRISPR-Cas9 screen was used to identify gene targets that enhance BC cell cytotoxicity in the presence of SI-12, and a parallel screen with an ER inhibitor was conducted to compare the activities of SRC-3 and ER alpha inhibition.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Rachel Bleach, Stephen F. Madden, James Hawley, Sara Charmsaz, Cigdem Selli, Katherine M. Sheehan, Leonie S. Young, Andrew H. Sims, Pavel Soucek, Arnold D. Hill, Marie McIlroy
Summary: This study suggests that adrenal androgenic steroid precursors and androgen receptor play important roles in breast cancer development, with some patients developing resistance to aromatase inhibitor therapy. The expression of androgen receptor was associated with patient survival, and changes in androgen levels may contribute to acquired resistance to anti-estrogen therapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A. Zebala, Dean Y. Maeda, James G. Christensen, Peter Olson, Argus Athanas, Cynthia A. Loomis, Aristotelis Tsirigos, Kwok-Kin Wong, Benjamin G. Neel
Summary: Our study suggests that inhibiting the SHP2/RAS/ERK pathway leads to upregulation of CXCR2 ligands and recruitment of S100A8 hi gMDSCs, suppressing T cells in non-small cell lung cancer. Combining SHP2/CXCR2 inhibitors can block gMDSC immigration, enhance Th1 polarization, induce highly cytotoxic CD8 + KLRG1 + effector T cells, and improve survival.
Article
Infectious Diseases
Guerrino Macori, Scott Nguyen, Ankita Naithani, Daniel Hurley, Li Bai, Farid El Garch, Frederique Woehrle, Christine Miossec, Benjamin Roques, Peadar O'Gaora, James L. Bono, Seamus Fanning
Summary: This study revealed a diverse population structure of Escherichia coli isolated from bovine faeces and milk samples, showing no specific correlation between phylogroups and pathotypes. The antimicrobial resistance of isolates was confirmed phenotypically, with genomic predictions successfully identifying resistance to colistin. Genetic analysis of four isolates found complex plasmids encoding both antibiotic resistant and virulence genes, including the mcr-1 resistance determinant. These findings provide early evidence of mcr-1 presence in Europe and highlight the diversity of resistance elements in E. coli strains associated with bovine diseases.
Article
Oncology
Alvaro Quintanal-Villalonga, Hirokazu Taniguchi, Yuan Hao, Andrew Chow, Yingqian A. Zhan, Shweta S. Chavan, Fathema Uddin, Viola Allaj, Parvathy Manoj, Nisargbhai S. Shah, Joseph M. Chan, Michael Offin, Metamia Ciampricotti, Jordana Ray-Kirton, Jacklynn Egger, Umesh Bhanot, Irina Linkov, Marina Asher, Michael H. Roehrl, Juan Qiu, Elisa de Stanchina, Travis J. Hollmann, Richard P. Koche, Triparna Sen, John T. Poirier, Charles M. Rudin
Summary: This study identified XPO1 as a therapeutic target in SCLC through CRISPR-Cas9 screening, and found that inhibition of XPO1 enhances the efficacy of chemotherapy. This discovery provides a new opportunity for the treatment of SCLC.
Article
Oncology
Li Qin, Jianwei Chen, Dong Lu, Prashi Jain, Yang Yu, David Cardenas, Xiaohui Peng, Xiaobin Yu, Jianming Xu, Jin Wang, Bert W. O. Malley, David M. Lonard
Summary: SI-10 and SI-12 are promising therapeutic agents that effectively inhibit the progression and metastasis of breast cancer by suppressing the viability, migration, and invasion of cancer cells.
ENDOCRINE-RELATED CANCER
(2021)
Article
Multidisciplinary Sciences
Ramesh Singh, Huan Meng, Tao Shen, Lance Edward V. Lumahan, Steven Nguyen, Hong Shen, Subhamoy Dasgupta, Li Qin, Dileep Karri, Bokai Zhu, Feng Yang, Cristian Coarfa, Bert W. O'Malley, Ping Yi
Summary: Castration-resistant prostate cancer (CRPC) is a major clinical challenge, and the androgen receptor (AR) is a critical oncogenic player. This study identifies TRAF4 as a key mediator of AR-regulated transcriptional reprogramming in CRPC, promoting its development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
