Article
Cell Biology
Rama Krishna Nimmakayala, Ayoola O. Ogunleye, Seema Parte, Nivedeta Krishna Kumar, Pratima Raut, Venkatesh Varadharaj, Naveen Kumar Perumal, Palanisamy Nallasamy, Sanchita Rauth, Jesse L. Cox, Subodh M. Lele, Surinder K. Batra, Moorthy P. Ponnusamy
Summary: This study reveals the cooperative role of PAF1 and YAP1 in the development of pancreatic cancer and identifies verteportin and CA3 as inhibitors that target the PAF1/YAP1/SOX9 axis to inhibit cancer cell growth.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Zhe Hong, Chengdang Xu, Shengfeng Zheng, Xinan Wang, Yiran Tao, Yao Tan, Guowen Lin, Denglong Wu, Dingwei Ye
Summary: NPM1 is overexpressed in prostate cancer cells and promotes proliferation by upregulating c-Myc expression. NPM1 cooperates with BRD4 to influence c-Myc transcription and facilitate prostate cancer progression. Blocking the NPM1-c-Myc oncogenic pathway may be a therapeutic strategy for prostate cancer.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Wei Jiang, Chengpeng Zhang, Yunteng Kang, Xiaojun Yu, Pei Pang, Guangbin Li, Yu Feng
Summary: MRPL42 is highly expressed in early-stage LUAD tissues and is associated with patient prognosis. Knocking down MRPL42 can affect the proliferation and migration ability of LUAD cells, while YY1 may regulate the expression of MRPL42.
Article
Biochemistry & Molecular Biology
Jiuna Zhang, Xiaoyu Jiang, Jie Yin, Shiying Dou, Xiaoli Xie, Ting Liu, Yijun Wang, Shuling Wang, Xue Zhou, Dongxuan Zhang, Huiqing Jiang
Summary: RNF141 plays an oncogenic role in colorectal cancer by upregulating KRAS activity, which promotes tumor growth, cell proliferation, migration, and apoptosis by interacting with KRAS to induce its activation and enrichment on the plasma membrane.
Article
Multidisciplinary Sciences
Edgar Pinedo-Carpio, Julien Dessapt, Adele Beneyton, Lauralicia Sacre, Marie-Anne Berube, Romain Villot, Elise G. Lavoie, Yan Coulombe, Andreanne Blondeau, Jonathan Boulais, Abba Malina, Vincent M. Luo, Anna-Maria Lazaratos, Jean-Francois Cote, Frederick A. Mallette, Alba Guarne, Jean-Yves Masson, Amelie Fradet-Turcotte, Alexandre Orthwein
Summary: Using CRISPR-based genomics, we identified FIRRM as a sensitizer of the ICL-inducing agent mafosfamide, highlighting its crucial role in resolving ICL-induced DSBs.
Article
Biochemistry & Molecular Biology
Yumei Huang, Xijie Yang, Yanwei Lu, Ye Zhao, Rui Meng, Sheng Zhang, Xiaorong Dong, Shuangbing Xu, Gang Wu
Summary: The study reveals the important role of UBE2O in radioresistance of lung cancer by promoting Mxi1 ubiquitination and degradation, facilitating tumor progression. Additionally, UBE2O is found to be overexpressed and negatively correlated with Mxi1 protein levels in lung cancer tissues.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Sreeram Vallabhaneni, Jian Liu, Marion Morel, Jixin Wang, Francesco J. DeMayo, Weiwen Long
Summary: ERK3, a poorly studied mitogen-activated protein kinase, has been shown to be upregulated in cancer, particularly promoting lung cancer cell growth and invasion. Using genetically engineered mouse models, the study revealed that ERK3 acts as an oncoprotein in promoting lung adenocarcinoma development and progression.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Li-Hsin Cheng, Chung-Chi Hsu, Hung-Wen Tsai, Wen-Ying Liao, Pei-Ming Yang, Tai-Yan Liao, Hsiao-Yen Hsieh, Tze-Sian Chan, Kelvin K. Tsai
Summary: Small cell lung cancer (SCLC) is a highly aggressive and deadly tumor. The upregulation of neurogenesis-associated protein ASPM-I1 is found in SCLC cells and is associated with poor patient prognosis. ASPM-I1 plays a crucial role in maintaining SCLC stemness and tumorigenesis through the regulation of multiple pathways and the Wnt signaling pathway.
Article
Oncology
Caleb N. Seavey, Andrea Hallett, Shuo Li, Kepeng Che, Ajaybabu Pobbati, Shuang Ma, Ashley Burtscher, Ryan Kanai, John M. Lamar, Brian P. Rubin
Summary: This study evaluated the effect of CDKN2A loss on EHE tumorigenesis. The loss of CDKN2A enhanced the invasiveness of EHE, leading to earlier tumor-related morbidity/mortality and increased tumor cell proliferation. Additionally, the study successfully established the first EHE cell lines, which replicated the transcriptional profile of EHE and generated EHE tumors in immunodeficient mice.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Hongling Chen, Li Zhao, Yuting Meng, Xixi Qian, Ya Fan, Quanli Zhang, Chao Wang, Fan Lin, Baoan Chen, Lin Xu, Wenbin Huang, Jing Chen, Xuerong Wang
Summary: SUR1-expressing cancer cells induce the transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs) in the tumor microenvironment and promote the progression of non-small cell lung carcinoma (NSCLC) by transferring less exosomal let-7a-5p. Glibenclamide targeting SUR1 is a promising anti-cancer drug, and the level of plasma exosomal let-7a-5p serves as a potential diagnostic biomarker for NSCLC patients.
Article
Immunology
Yinnan Meng, Wei Wang, Meng Chen, Kuifei Chen, Xinhang Xia, Suna Zhou, Haihua Yang
Summary: The study reveals that the interaction between IDO1 and GBP1 promotes the malignant progression of lung cancer by increasing the extracellular secretion of IDO1. Astragaloside IV inhibits this process by blocking the interaction between IDO1 and GBP1, reducing T cell exhaustion and inhibiting tumor progression. Blocking the extracellular secretion of IDO1 may enhance the efficacy of PD-1 inhibitors in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang
Summary: This study identified an important immune cytokine, CXCL7, secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jiawei Yue, Hui Guo, Peng Xu, Jinhong Ma, Yumin Wu
Summary: Lung cancer is a common and aggressive cancer type. Activation of GPR35 may promote tumor development by enhancing the production of IL-5 and IL-13, leading to the formation of the ILC2-MDSC axis. Additionally, GPR35 is a poor prognostic factor in patients with lung adenocarcinoma. Targeting GPR35 could be a potential strategy for cancer immunotherapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: The study found that T-cell immunoglobulin and mucin domain-containing molecule 4 (TIM-4) promotes the growth and proliferation of lung cancer cells by enhancing mitochondrial fusion and oxidative phosphorylation pathway.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Yunping Hu, Yong Lu, Fei Xing, Wesley Hsu
Summary: This study reveals a mechanism of immune escape in lung cancer, showing that activation of the transcription factor brachyury leads to upregulation of PD-L1, inhibiting T cell proliferation and infiltration. Blocking the FGFR1/MAPK pathway reverses immune suppression and enhances the therapeutic response to anti-PD-1 treatment.
Letter
Oncology
Gennie L. Parkman, David A. Kircher, Christopher M. Stehn, Martin McMahon, Sheri L. Holmen
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Renhua Na, Kyoko Miura, Suzanne O'Brien, Guy D. Eslick, Bradley J. Kendall, Luke F. Hourigan, Michael Bourke, Michael R. Cox, Laal Farrokhzadi, Angelique J. Levert-Mignon, Andrew P. Barbour, Nicholas J. Clemons, Cuong P. Duong, Reginald Lord, Wayne A. Phillips, David Watson, David C. Whiteman
Summary: Prospective data indicate that the presence of dysplasia is a stronger predictor of cancer progression in patients with Barrett's esophagus than segment length.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Multidisciplinary Sciences
Julia Milne, Bonnie Z. Zhang, Kenji M. Fujihara, Swati Dawar, Wayne A. Phillips, Nicholas J. Clemons
Summary: This study reveals that TKT expression serves as a determinant for sensitivity to APR-246 in p53-null cells. Despite mutant-p53 not directly regulating TKT expression, manipulating TKT levels significantly impacts sensitivity to the drug.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Gastroenterology & Hepatology
Nicholas J. Clemons, Wayne A. Phillips
Article
Gastroenterology & Hepatology
Jovana R. Gotovac, Tanjina Kader, Julia Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons
Summary: The study explores the impact of SMAD4 loss on TGF-beta signaling and tumorigenicity in high-grade dysplastic Barrett's cells. SMAD4 knockout alters the expression of TGF-beta target genes, upregulating potential oncogenes and downregulating tumor-suppressor genes. Inactivation of SMAD4 promotes tumorigenesis and genomic instability, suggesting that SMAD4 plays a critical role in EAC development and progression.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Kenji M. Fujihara, Mariana Corrales Benitez, Carlos S. Cabalag, Bonnie Z. Zhang, Hyun S. Ko, David S. Liu, Kaylene J. Simpson, Ygal Haupt, Lara Lipton, Sue Haupt, Wayne A. Phillips, Nicholas J. Clemons
Summary: This study aims to identify a robust biomarker for response to APR-246 and found that the expression of SLC7A11 is a superior determinant of sensitivity to APR-246. Therefore, SLC7A11 should be utilized as the key predictive biomarker to stratify patients for future clinical investigation of APR-246.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Vincent T. Janmaat, Kateryna Nesteruk, Manon C. W. Spaander, Auke P. Verhaar, Bingting Yu, Rodrigo A. Silva, Wayne A. Phillips, Marcin Magierowski, Anouk van de Winkel, H. Scott Stadler, Tatiana Sandoval-Guzman, Luc J. W. van der Laan, Ernst J. Kuipers, Ron Smits, Marco J. Bruno, Gwenny M. Fuhler, Nicholas J. Clemons, Maikel P. Peppelenbosch
Summary: The expression of the distal HOX gene HOXA13 in Barrett's esophagus is proposed to underlie the phenotypic aspects of metaplasia and increased proliferation. This expression may confer a competitive advantage to cells and contribute to the expansion of the gastro-esophageal HOXA13-expressing compartment, leading to the development of Barrett's esophagus and associated esophageal adenocarcinoma. Barrett's esophagus is described as a pro-oncogenic lesion in the proximal gastrointestinal tract with a distal colon-like morphology.
NATURE COMMUNICATIONS
(2021)
Review
Dermatology
Gennie L. Parkman, Mona Foth, David A. Kircher, Sheri L. Holmen, Martin McMahon
Summary: Phosphatidylinositol-3'-kinases (PI3Ks) are a family of lipid kinases that regulate various biological processes by phosphorylating inositol ring of phosphatidylinositides. Activation of PI3K leads to accumulation of PI3K-lipids, which play important roles in cell growth, death, and metabolism. In cancers, aberrant activation of PI3K pathway cooperates with other protein kinases to promote tumor progression and metastasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Cell Biology
Glen R. Guerra, Joseph C. Kong, Rosemary M. Millen, Matthew Read, David S. Liu, Sara Roth, Shienny Sampurno, Joseph Sia, Maria-Pia Bernardi, Timothy J. Chittleborough, Corina C. Behrenbruch, Jiasian Teh, Huiling Xu, Nicole M. Haynes, Jiaan Yu, Richard Lupat, David Hawkes, Natasha Di Costanzo, Richard W. Tothill, Catherine Mitchell, Samuel Y. Ngan, Alexander G. Heriot, Robert G. Ramsay, Wayne A. Phillips
Summary: This study established and validated a panel of human anal squamous cell carcinoma cell lines, demonstrating similar genetic and molecular characteristics to ASCC, tumor formation capability, and varied drug responses, providing an important resource for the study of the biology and therapeutics of this rare disease.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Ian Y. Luk, Laura J. Jenkins, Kael L. Schoffer, Irvin Ng, Janson W. T. Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D. Burrows, Robin L. Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F. Richardson, Oliver M. Sieber, Yang Liao, Jennifer K. Mooi, Natalia Vukelic, Camilla M. Reehorst, Shoukat Afshar-Sterle, Vicki L. J. Whitehall, Lochlan Fennell, Helen E. Abud, Niall C. Tebbutt, Wayne A. Phillips, David S. Williams, Wei Shi, Lisa A. Mielke, Matthias Ernst, Amardeep S. Dhillon, Nicholas J. Clemons, John M. Mariadason
Summary: In this study, co-ordinate epigenetic inactivation of two epithelial-specific transcription factors, EHF and CDX1, was identified as a mechanism driving differentiation loss in CRCs. Re-expression of EHF and CDX1 induced extensive chromatin remodelling, transcriptional re-programming, and differentiation in poorly-differentiated CRC cells, leading to reduced growth and metastasis. These findings reveal a novel mechanism driving epithelial de-differentiation and tumor progression in CRC.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Biochemistry & Molecular Biology
Alexandra M. Simond, Tung Bui, Dongmei Zuo, Virginie Sanguin-Gendreau, Trisha Rao, Wayne A. Phillips, Robert D. Cardiff, William J. Muller
Summary: This study found that the p110 alpha(HR) mutation attenuates metastatic behavior and is associated with the formation of ductal carcinoma in situ (DCIS) in ErbB2-driven breast cancer.
Article
Oncology
Jeffrey Molendijk, Cathryn M. Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K. Shah, Ian Brown, Mark P. Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S. Richards, Michael Gartside, Kalpana Patel, Nicholas J. Clemons, Wayne A. Phillips, Andrew Barbour, Johan A. Westerhuis, Michelle M. Hill
Summary: Integrated multiomics revealed rewiring of sphingolipid and phospholipid metabolism during esophageal adenocarcinoma (EAC) development. The study identified enzymes associated with this process and found that inhibiting specific enzymes effectively protected cells from lipid peroxidation-induced DNA damage.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yuchen Bai, Carolin Gotz, Ginevra Chincarini, Zixuan Zhao, Clare Slaney, Jarryd Boath, Luc Furic, Christopher Angel, Stephen M. Jane, Wayne A. Phillips, Steven A. Stacker, Camile S. Farah, Charbel Darido
Summary: Subtype-specific treatment regimens are currently lacking for heterogeneous head and neck cancer (HNC). An integrated analysis of HNC subtypes using single-cell sequencing and proteome profiles reveals an epithelial-mesenchymal transition (EMT) signature and its correlation with PI3K/mTOR signaling pathway. YBX1 phosphorylation downstream of PI3K/mTOR pathway inhibits basal-like cancer cell proliferation, while acting as a safeguard against the proliferation-to-invasion switch in mesenchymal-like epithelial cancer cells. Phospho-YBX1 that is mutually exclusive to partial-EMT emerges as a prognostic marker for overall patient outcomes. These findings provide a promising therapeutic approach against HNC by sensitizing mesenchymal cancer cells to PI3K/mTOR inhibitors through shifting them towards a basal-like subtype.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Julia V. Milne, Jovana R. Gotovac, Kenji M. Fujihara, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons
Meeting Abstract
Oncology
Carlos Suhady Cabalag, Michael Yates, Mariana B. Corrales, Paul Yeh, Stephen Q. Wong, Bonnie Zhang, Kenji M. Fujihara, Lynn Chong, Michael Hii, Sarah-Jane Dawson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons