Review
Oncology
Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao
Summary: Metastasis is a complex process that relies on the interaction between tumor cells and host organs, with the formation of a pre-metastasis niche being crucial. Myeloid-derived suppressor cells play a key role in this process, and targeting these cells as a therapeutic strategy may help inhibit the formation of the pre-metastasis niche and curb tumor metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lionel Gillot, Alizee Lebeau, Louis Baudin, Charles Pottier, Thomas Louis, Tania Durre, Remi Longuespee, Gabriel Mazzucchelli, Christophe Nizet, Silvia Blacher, Frederic Kridelka, Agnes Noel
Summary: This study revealed an association between POSTN deposition and lymphangiogenesis in lymph nodes of cervical cancer patients, highlighting the key role of POSTN in promoting lymphatic vessel formation and the seeding of metastatic cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yuping Liu, Dengxuan Mao, Hong Wang, Xiaoyu Che, Yan Chen
Summary: Tumor cells-derived EVs play a crucial role in the formation of PMN in the lung and can potentially be utilized as a target or carrier for the intervention of lung PMN.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Oncology
Benjamin Ormseth, Amblessed Onuma, Hongji Zhang, Allan Tsung
Summary: The pre-metastatic niche (PMN) is a targeted therapy that prevents cancer metastasis before it occurs. The communication between primary tumors and the liver establishes a microenvironment that increases susceptibility to tumor cell invasion and outgrowth. Understanding the mechanisms of the PMN could provide opportunities for clinical intervention and potentially serve as biomarkers.
Article
Engineering, Biomedical
Chunyu Xia, Wenjing Bai, Tao Deng, Ting Li, Ling Zhang, Zhengze Lu, Zhirong Zhang, Man Li, Qin He
Summary: A sponge-like neutrophil membrane-coated nano-system was developed to inhibit tumor recurrence and metastasis by inhibiting the recruitment and functions of myeloid-derived suppressor cells (MDSCs), which reinforced anti-tumor immunity and also suppressed pulmonary metastasis by inhibiting the formation of pre-metastatic niche (PMN). This nano-system not only showed natural tropism to postoperative inflammatory site but also relieved MDSCs-mediated immunosuppression. Additionally, it suppressed the formation of PMN to inhibit pulmonary metastasis.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Katsuaki Ieguchi, Masabumi Funakoshi, Taishi Mishima, Kohtaro Takizawa, Tsutomu Omori, Fumio Nakamura, Makoto Watanabe, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Yoshiro Maru, Satoshi Wada
Summary: Emerging evidence suggests that neural activity contributes to tumor initiation and metastasis. Specifically, the sympathetic nervous system has been found to regulate tumor angiogenesis, growth, and metastasis. By performing chemical sympathectomy, researchers observed a decrease in lung metastasis and identified neuro-immune cell interactions in tumor-bearing mouse lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Qi Dong, Xue Liu, Ke Cheng, Jiahao Sheng, Jing Kong, Tingjiao Liu
Summary: Primary tumors modify the microenvironment of distant organs to create a supportive pre-metastatic niche, facilitating metastasis. Extracellular vesicles play a critical role in PMN formation by delivering functional molecules to recipient cells in target organs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Isak W. Tengesdal, Suzhao Li, Nicholas E. Powers, Makenna May, Charles P. Neff, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: The study reveals the significant role of the NLRP3 inflammasome in metastatic breast cancer, with NLRP3 activation being a key driver of immune suppression. Inhibiting NLRP3 can reduce tumor growth, increase survival, and decrease infiltration of MDSCs in the tumor microenvironment.
Article
Public, Environmental & Occupational Health
Badarni Karawan, Weiner Zeev, Szwarcwort-Cohen Moran, Zaltzman-Bershadsky Nelly, Paul Mical, Ghanem-Zoubi Nesrin
Summary: The seroprevalence of Q fever among pregnant women with pre-term birth reached 4% in northern Israel. The study found a higher percentage of immunosuppressed women among the seropositive group. However, there was no significant difference in the proportion of infants born small for gestational age between seropositive and seronegative women.
ZOONOSES AND PUBLIC HEALTH
(2023)
Article
Oncology
Honglin Li, Feiran Yang, Lei Zhang, Ruohan Zhao, Xiurong Li, Huijie Li
Summary: This study found that Xiaoliu Pingyi recipe (XLPYR) can inhibit tumor growth and prevent lung metastasis, and reduce the proportion of myeloid-derived suppressor cells (MDSCs). Moreover, XLPYR can also reduce the expression of S100A8, MMP9, LOX, and IL-6/STAT3 in premetastatic lung tissue. Therefore, XLPYR may be an effective drug for preventing lung metastasis.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Oncology
Colt Egelston, Weihua Guo, Susan Yost, Jin Sun Lee, David Rose, Christian Avalos, Jian Ye, Paul Frankel, Daniel Schmolze, James Waisman, Peter Lee, Yuan Yuan
Summary: This study highlights that patients with HR+ MBC treated with a combination of CDK4/6 inhibitor and ICI show increased frequencies of effector memory CD8+ and CD4+ T cells in their peripheral blood, which may serve as potential biomarkers of clinical response. Additionally, changes in myeloid cell composition were observed in patients receiving the combination therapy, indicating a dynamic modulation of the immune system in response to treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Hao Wang, Junjie Pan, Livnat Barsky, Jule Caroline Jacob, Yan Zheng, Chao Gao, Shun Wang, Wenwei Zhu, Haoting Sun, Lu Lu, Huliang Jia, Yue Zhao, Christiane Bruns, Razi Vago, Qiongzhu Dong, Lunxiu Qin
Summary: Metastasis is a major cause of cancer-related deaths, with the pre-metastatic niche playing a crucial role in the colonization and development of tumor cells into metastases. Developing a deep understanding of the formation, characteristics, and function of the pre-metastatic niche is essential for devising new therapeutic strategies to prevent tumor metastasis at an early stage. Therapies targeting the pre-metastatic niche show promise in averting tumor metastasis, highlighting the importance of further research in this area.
MOLECULAR BIOMEDICINE
(2021)