Article
Cell Biology
Longyuan Gong, Danrui Cui, Dian Liu, Xiao Shen, Hui Pan, Xiufang Xiong, Yongchao Zhao
Summary: FBXW7 regulates cellular senescence by targeting p53 for degradation, leading to cell growth arrest and activation of the p53/p21 and p16(INK4a)/Rb pathways.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Elena Montano, Alessandra Pollice, Valeria Lucci, Geppino Falco, Ornella Affinito, Girolama La Mantia, Maria Vivo, Tiziana Angrisano
Summary: Identification of molecular mechanisms controlling early cell fate decisions in mammals is crucial for potential therapies. Ink4a and Arf from the Cdkn2a locus mark an early pancreatic cellular state resembling Pancreatic Progenitor Cells (PPCs). Chromatin remodeling may play a role in regulating the CDKN2a locus during pancreatic lineage commitment.
Review
Biochemistry & Molecular Biology
Jingyi Fan, Marcia Bellon, Mingyi Ju, Lin Zhao, Minjie Wei, Liwu Fu, Christophe Nicot
Summary: FBXW7 is a component of the SCF/beta-TrCP complex and plays a role in phosphorylation-dependent ubiquitination and proteasome degradation of oncoproteins. It affects various regulatory functions and its dysregulation is associated with cancer. FBXW7 expression and functions are regulated through multiple mechanisms, and its inactivation is frequently observed in lung, colon, and hematopoietic cancers. Mutations in FBXW7 result in differential degradation of specific cellular targets, leading to distinct activation/inactivation patterns in cell signaling pathways.
Article
Oncology
Markus Kaller, Wenjing Shi, Heiko Hermeking
Summary: Loss of AP4 in breast cancer cells leads to DNA damage, senescence, and reduced proliferation. Deletion of p53 can reverse the senescence and proliferation defects in AP4-deficient cells. Loss of AP4 enhances the repression of DREAM and E2F target genes induced by c-MYC through p53.
Article
Multidisciplinary Sciences
Eri Tabata, Akinori Kashimura, Azusa Kikuchi, Hiromasa Masuda, Ryo Miyahara, Yusuke Hiruma, Satoshi Wakita, Misa Ohno, Masayoshi Sakaguchi, Yasusato Sugahara, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Eri Tabata, Akinori Kashimura, Maiko Uehara, Satoshi Wakita, Masayoshi Sakaguchi, Yasusato Sugahara, Terumi Yurimoto, Erika Sasaki, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Masahiro Kimura, Takatoshi Umeyama, Satoshi Wakita, Kazuaki Okawa, Masayoshi Sakaguchi, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Neurosciences
Peter O. Bauer, Judith H. Dunmore, Hiroki Sasaguri, Vaclav Matoska
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Eri Tabata, Satoshi Wakita, Akinori Kashimura, Yasusato Sugahara, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Masahiro Kimura, Takashi Watanabe, Kazutaka Sekine, Hitomi Ishizuka, Aoi Ikejiri, Masayoshi Sakaguchi, Minori Kamaya, Daisuke Yamanaka, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Multidisciplinary Sciences
Maiko Uehara, Eri Tabata, Mikoto Okuda, Yukari Maruyama, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Summary: The crab-eating monkey has a diverse diet including plants and animals, with its CHIA enzyme showing higher activity under different conditions, especially in a broad range of temperature and pH levels. Mf-CHIA exhibits superior chitinolytic activity compared to Mm-CHIA towards polymeric chitin and an artificial chromogenic substrate.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Eri Tabata, Akihiro Itoigawa, Takumi Koinuma, Hiroshi Tayama, Akinori Kashimura, Masayoshi Sakaguchi, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Summary: The study revealed that the evolution in Carnivora due to a noninsect-based diet has caused structural and functional changes in acidic chitinase (Chia). Different levels of chitinolytic activity were observed in Chia proteins from various carnivorous species, with some species having Chia in pseudogene form.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Satoshi Wakita, Yasusato Sugahara, Masayuki Nakamura, Syunsuke Kobayashi, Kazuhisa Matsuda, Chinatsu Takasaki, Masahiro Kimura, Yuta Kida, Maiko Uehara, Eri Tabata, Koji Hiraoka, Shiro Seki, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Summary: The study shows that mouse Chia can degrade homogenously deacetylated chitosan into chitooligosaccharides, which may influence different physiological or pathological processes.
Article
Biochemistry & Molecular Biology
Maiko Uehara, Chinatsu Takasaki, Satoshi Wakita, Yasusato Sugahara, Eri Tabata, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Summary: Monkey CHIA can efficiently degrade chitin and chitosan under high-temperature or low pH conditions, and the reaction conditions can be adjusted to obtain desired oligomers.
Article
Orthopedics
Pavel Neckar, Hana Potockova, Jaroslav Branis, Vojtech Havlas, Tomas Novotny, Dominika Lykova, Jana Gujski, Ivana Drahoradova, Katerina Ruzickova, Jana Kaclova, Petr Skala, Peter O. Bauer
Summary: This study evaluated the safety and efficacy of using autologous bone marrow mesenchymal stem cells (BM-MSCs) attached to a 3D scaffold for the treatment of knee cartilage defects. The results showed that this treatment method was safe and effective, with significant improvement in knee joint function within one year.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Biochemistry & Molecular Biology
Kazuaki Okawa, Eri Tabata, Yuta Kida, Kyohei Uno, Hidetoshi Suzuki, Minori Kamaya, Peter O. O. Bauer, Fumitaka Oyama
Summary: This study investigates the loss of enzymatic activity in the Ym1 protein compared to Chia. It identifies three protein segments responsible for the loss: the catalytic motif residues, exons 6 and 7, and exon 10. The study also finds extensive gene duplication events specific to rodent lineages at the Ym1 locus and suggests that amino acid substitutions in regions involved in chitin recognition, binding, and degradation lead to irreversible inactivation of the protein.
Article
Multidisciplinary Sciences
Masahiro Kimura, Takatoshi Umeyama, Satoshi Wakita, Kazuaki Okawa, Masayoshi Sakaguchi, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama
Article
Orthopedics
P. Neckar, V Havlas, D. Lykova, J. Branis, J. Kvizova, P. O. Bauer
ACTA CHIRURGIAE ORTHOPAEDICAE ET TRAUMATOLOGIAE CECHOSLOVACA
(2020)
Article
Biology
Miroslava Jandova, Pavel Sponer, Doris Vokurkova, Peter O. Bauer, Alzbeta Filipova, Stanislav Filip, Pavel Mericka