Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anesthesiology
Weiwei Bao, Jiahui Ding, Shan Jiang, Zhen Yao, Weimin Qu, Wenxian Li, Zhili Huang, Yuan Han
Summary: This study explored the downstream neural mechanism of nucleus accumbens (NAc) neurons that express dopamine D1 receptor (D1R) in the modulation of emergence from sevoflurane general anesthesia (GA). The researchers traced the projections of NAcD1R neurons and found that optogenetic activation of NAcD1R-VP or NAcD1R-LH circuit induced cortical activation and behavioral emergence during sevoflurane-induced anesthesia. These findings suggest that both NAcD1R-VP and NAcD1R-LH circuits play a crucial role in promoting reanimation from sevoflurane GA.
ANESTHESIA AND ANALGESIA
(2023)
Article
Oncology
Heba Allah M. Alsheikh, Brandon J. Metge, Chae-Myeong Ha, Dominique C. Hinshaw, Mateus S. V. Mota, Sarah C. Kammerud, Tshering Lama-Sherpa, Noha Sharafeldin, Adam R. Wende, Rajeev S. Samant, Lalita A. Shevde
Summary: This study established a type 2 diabetic mouse model of triple-negative mammary carcinoma and investigated the effect of metformin on tumor characteristics and immune/metabolic microenvironment. The results showed that diabetic mice had larger mammary tumors with altered stromal profile compared to nondiabetic/lean mice, and metformin treatment effectively normalized glucose levels and decreased metastatic seeding. These findings indicate the impact of diabetes and obesity on tumor cell attributes and metformin's ability to revert tumor cell and stromal changes in an obese and diabetic host environment.
Article
Biochemistry & Molecular Biology
Rashmi Kumari, Zainab Y. Kareem, Patricia J. McLaughlin
Summary: Diabetic patients have a suppressed immune system, both in the periphery and within the central nervous system, which contributes to their poor outcome after ischemic stroke. Low doses of naltrexone (LDN) can improve clinical outcomes by balancing inflammatory factors and promoting neuronal recovery. In the diabetic mouse model, LDN treatment increased beta-endorphin and opioid growth factor levels, and improved neuronal recovery post hypoxia-ischemia.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kaiyong Yang, Zijian Li, Fangzhou Yin, Xiaojun Ji, Jiaqian Zhou, Xin Li, Tao Zeng, Chenghao Fei, Chenchen Ren, Yulin Wang, Lei Fang, Lili Chen, Pei Zhang, Liyan Mu, Yuxuan Qian, Yan Chen, Wu Yin
Summary: Endogenous ouabain (EO) is elevated in patients with NSCLC and closely related to tumor stage, metastasis, and survival. EO promotes TIM suppression in vivo by modulating the expression of immune checkpoint proteins, particularly PD-L1. EO increases PD-L1 transcription, but its receptor Na, K-ATPase alpha 1 interacts with PD-L1 to induce its endocytic degradation, finely controlling PD-L1 expression and dampening tumoral immunity.
Article
Cell Biology
Danlei Chen, Yan Yan, Xinyi Wang, Suzhi Li, Yan Liu, Dandan Yu, Yongjing He, Ruiqing Deng, Yakun Liu, Mei Xu, Jia Luo, Hongjun Gao, Siying Wang
Summary: This study found that chronic alcohol exposure promotes the progression of hepatocellular carcinoma (HCC), with miR-22-3p and TET2 playing important roles in this process, affecting the stemness, tumor growth, and metastasis of HCC cells.β-catenin was identified as an upstream activator of miR-22-3p, indicating the involvement of the beta-catenin/miR-22-3p/TET2 regulatory axis in alcohol-induced HCC malignancy.
Article
Oncology
Alexandra Q. Bartlett, Nathan D. Pennock, Alex Klug, Pepper Schedin
Summary: This study discusses the mechanisms of breast cancer cells invading the liver and forming metastatic niches. The research found that the process of liver involution increases liver metastasis, which is associated with unique immunological properties in the involuting liver.
Article
Cell Biology
Lina Qi, Jiani Chen, Biting Zhou, Kailun Xu, Kailai Wang, Zhihao Fang, Yingkuan Shao, Ying Yuan, Shu Zheng, Wangxiong Hu
Summary: HOXC6 is overexpressed in right-sided colon cancer and promotes migration and invasion of colon cancer cells by activating the Wnt/beta-catenin signaling pathway. Silencing of HOXC6 can make colon cancer cells more sensitive to irinotecan.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Dafeng Tong, Jie Yuan, Zhaoming Wang, Enda Yu, E. Jifu
Summary: Ubiquitin-specific peptidase 37 (USP37) is up-regulated in colorectal cancer (CRC) and its high expression is associated with poor patient survival. Up-regulation of USP37 promotes various malignant characteristics of CRC cells, including proliferation, migration, invasion, and stemness, and also enhances angiogenesis. Silencing USP37 shows the opposite effects. Mechanistically, USP37 stabilizes beta-catenin by inhibiting its ubiquitination. CTNNB1, the gene encoding beta-catenin, is positively correlated with USP37 in CRC. Targeting USP37 may hold potential for CRC treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Engineering, Biomedical
Qianwen Yu, Xian Tang, Wei Zhao, Yue Qiu, Jiao He, Dandan Wan, Jianping Li, Xuhui Wang, Xuan He, Yayuan Liu, Man Li, Zhirong Zhang, Qin He
Summary: The combination of mild hyperthermia and immune checkpoint blockade treatment effectively suppressed tumor growth and metastasis; size-adjustable nanoparticles have great potential in improving cancer treatment outcomes.
ACTA BIOMATERIALIA
(2021)
Article
Cell Biology
A-bin You, Hu Yang, Chun-ping Lai, Wen Lei, Lu Yang, Jia-lin Lin, Shun-cui Liu, Nan Ding, Feng Ye
Summary: The expression of CMTR1 is elevated in colorectal cancer tissues and is associated with poor prognosis. Inhibition of CMTR1 suppresses tumor cell proliferation and tumorigenicity, and enhances the efficacy of PD1 blockade immunotherapy.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Violet A. Kiesel, Madeline P. Sheeley, Emily M. Hicks, Chaylen Andolino, Shawn S. Donkin, Michael K. Wendt, Stephen D. Hursting, Dorothy Teegarden
Summary: Regions of hypoxia in solid tumors contribute to gene expression changes and increased risk of cancer metastasis. This study found that metastatic cancer cells exhibit stronger metabolic suppression and antioxidant response to hypoxia, indicating their ability to adapt and survive in low oxygen conditions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Langmei Deng, Shuangshuang Zeng, Qiaoli Yi, Liying Song
Summary: Recent studies have shown that ferroptosis, a type of iron-dependent regulated cell death, may contribute to tumor initiation and progression. STEAP3, a ferrireductase involved in intracellular iron homeostasis, has been found to be up-regulated in certain types of cancer. However, its clinical significance and biological function in human cancers are still not well understood.
Article
Cell Biology
Qiaorui Bai, Xia Yang, Quanfeng Li, Weizhong Chen, Han Tian, Rong Lian, Ximeng Liu, Shuang Wang, Yi Yang
Summary: By analyzing single-cell RNA sequencing data, researchers identified that FABP7 gene is specifically up-regulated in tumor cells of metastatic NSCLC patients and may serve as a prognostic indicator for poor survival. Experimental studies further showed that FABP7 promotes the metastatic competencies of NSCLC cells by inhibiting the degradation of specific cytoplasmic molecules in the Wnt signaling pathway.
Article
Endocrinology & Metabolism
Omkaram Gangisetty, Shaima Jabbar, Olivia Wynne, Dipak K. Sarkar
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Oncology
Gao Zhang, Lawrence W. Wu, Ilgen Mender, Michal Barzily-Rokni, Marc R. Hammond, Omotayo Ope, Chaoran Cheng, Themistoklis Vasilopoulos, Sergio Randell, Norah Sadek, Aurelie Beroard, Min Xiao, Tian Tian, Jiufeng Tan, Umar Saeed, Eric Sugarman, Clemens Krepler, Patricia Brafford, Katrin Sproesser, Sengottuvelan Murugan, Rajasekharan Somasundaram, Bradley Garman, Bradley Wubbenhorst, Jonathan Woo, Xiangfan Yin, Qin Liu, Dennie T. Frederick, Benchun Miao, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Lawrence N. Kwong, Ravi K. Amaravadi, Yiling Lu, Genevieve M. Boland, Zhi Wei, Katherine Nathanson, Utz Herbig, Gordon B. Mills, Keith T. Flaherty, Meenhard Herlyn, Jerry W. Shay
CLINICAL CANCER RESEARCH
(2018)
Article
Substance Abuse
Omkaram Gangisetty, Rajita Sinha, Dipak K. Sarkar
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Oncology
Rani Ojha, Nektaria M. Leli, Angelique Onorati, Shengfu Piao, Ioannis I. Verginadis, Feven Tameire, Vito W. Rebecca, Cynthia I. Chude, Sengottuvelan Murugan, Colin Fennelly, Estela Noguera-Ortega, Shujing Liu, Xiaowei Xu, Clemens Krepler, Min Xiao, Wei Xu, Zhi Wei, Dennie T. Frederick, Genevieve Boland, Tara C. Mitchell, Giorgos C. Karakousis, Lynn M. Schuchter, Keith T. Flaherty, Gao Zhang, Meenhard Herlyn, Constantinos Koumenis, Ravi K. Amaravadi
Article
Substance Abuse
Dipak K. Sarkar, Omkaram Gangisetty, Jeffrey R. Wozniak, Judith K. Eckerle, Michael K. Georgieff, Tatiana M. Foroud, Leah Wetherill, Wladimir Wertelecki, Christina D. Chambers, Edward Riley, Natalya Zymak-Zakutnya, Lyubov Yevtushok
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Oncology
Omkaram Gangisetty, Ajay Palagani, Dipak K. Sarkar
CLINICAL EPIGENETICS
(2020)
Article
Endocrinology & Metabolism
Ali Al-Yasari, Shaima Jabbar, Miguel A. Cabrera, Benedicte Rousseau, Dipak K. Sarkar
Summary: The study found that preconception alcohol exposure in female rats led to changes in the stress gene network involving glucose metabolism in oocytes, resulting in offspring with significant hyperglycemia and hypoinsulinemia in adulthood. These offspring also exhibited increased levels of inflammatory cytokines and cellular apoptosis in the pancreas, as well as altered insulin production and actions in the liver, and a reduced number of proopiomelanocortin neurons in the hypothalamus. Replenishment of proopiomelanocortin neurons normalized glucose abnormalities, suggesting that preconception alcohol exposures can impact glucose homeostasis through inducing neuronal functional abnormalities.
Article
Oncology
Sengottuvelan Murugan, Benedicte Rousseau, Dipak K. Sarkar
Summary: The combination of beta blocker propranolol and opiate antagonist naltrexone has shown significant inhibitory effects on tumor growth and mass, while also improving survival rates. Testing in preclinical breast cancer models demonstrated potent antitumor effects, suggesting a potential new combinatorial treatment strategy for clinical use.
Article
Multidisciplinary Sciences
Omkaram Gangisetty, Shaista Chaudhary, Ajay Palagani, Dipak K. Sarkar
Summary: This study found that fetal alcohol exposure induces heritable changes in Pomc-related variants, leading to increased stress response and anxiety-like behavior in multiple generations of isogenic Fischer 344 rats. These effects were transmitted through the male germline and involve epigenetic modifications of the Pomc gene.
Review
Substance Abuse
Ujjal Das, Omkaram Gangisetty, Shaista Chaudhary, Prashant Tarale, Benedicte Rousseau, Julianne Price, Ian Frazier, Dipak K. Sarkar
Summary: Using publicly available gene expression datasets, we conducted a systematic review with meta-analytic elements to determine the role of epigenetic mechanisms in prenatal alcohol exposure-induced dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis in offspring. Our network analysis identified key pathways associated with alcohol-mediated epigenetic alterations and provided insights into the developmental effects of alcohol on the HPA axis.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Shaista Chaudhary, Dipak K. Sarkar
Summary: It is currently unknown whether fetal alcohol exposure promotes the biochemical characteristics of Alzheimer's disease.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Cell Biology
Sayani Mukherjee, Prashant Tarale, Dipak K. Sarkar
Summary: This review explores the role of glial cell pathologies, particularly microglia, in fetal alcohol spectrum disorders (FASD). It examines the impact of neuroimmune molecules, signaling pathways, and epigenetic mechanisms on brain function alterations related to FASD. The review also highlights the significance of extracellular vesicles (EVs) in neuron-glia interactions during prenatal alcohol exposure. Potential applications involving nutritional, pharmacological, cell-based, and exosome-based therapies for FASD treatment are discussed.
Meeting Abstract
Substance Abuse
Dipak K. Sarkar, Shaima Jabbar, Lucy G. Chastain, Omkaram Gangisetty, Miguel A. Cabrera, Kamil Sochacki
Article
Substance Abuse
Lucy G. Chastain, Dipak K. Sarkar