Article
Medicine, Research & Experimental
Irina Ushach, Ren Zhu, Elen Rosler, Rajendra K. Pandey, N. Tilani S. De Costa, Soheil Pourshahian, Qinglin Han, Chris Li, Leonid Beigelman, Sergei M. Gryaznov, Theodore Yun
Summary: The study aimed to design a novel immunomodulator to subvert immune tolerance to HBV, showing promising results in inducing strong immune responses against the virus by targeting CpG oligonucleotide to lymphoid organs in a mouse model of chronic HBV infection.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Engineering, Biomedical
Alexandra Atalis, J. Brandon Dixon, Krishnendu Roy
Summary: This study compared how different types of adjuvants and delivery methods influence chemotaxis of dendritic cells, providing insights for the rational design of vaccine formulations.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Guiyuan Chen, Xiangxia Li, Rui Li, Kecheng Wu, Zhouhang Lei, Ruike Dai, Kyle Roche, Andrew Z. Wang, Yuanzeng Min
Summary: Researchers hypothesized that treating cancer cells with ultrahigh doses of chemotherapeutics in vitro could artificially enhance the immunogenicity, thereby improving chemoimmunotherapy.
Article
Biology
Caleb Gonzalez, Sarah Williamson, Seth T. Gammon, Sarah Glazer, Joon Haeng Rhee, David Piwnica-Worms
Summary: TLR5 agonists in combination with immune checkpoint therapies enhance survival in ICT-refractory murine tumors. Low serum levels of G-CSF and CXCL5 correlate with enhanced survival.
COMMUNICATIONS BIOLOGY
(2023)
Article
Engineering, Environmental
Li Wang, Yinghui Zhong, Qianqian Wu, Yu Wang, Ruoqi Tang, Silu Zhou, Jingde Yang, Qiming Liu, Guoxin Shi, Yanan Tang, Xianglong Meng, Kexin Chen, Xianqiang Yan, Xuelei Liu, Jing Zhan, Thomas M. Roberts, Song Liang, Jiaao Yu, Zhenning Liu
Summary: Two types of spermidine-functionalized biomaterials have been fabricated and shown to inhibit inflammatory responses and promote wound healing through in vitro and in vivo experiments. The findings of the proteomic analysis suggest possible mechanisms underlying these effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biotechnology & Applied Microbiology
Hengyi Wang, Yuanliang Xia, Baoqin Li, Yuehong Li, Changfeng Fu
Summary: Spinal cord injury (SCI) is a severe and traumatic disorder that leads to the loss of motor, sensory, and autonomic nervous function. The persistence of local immune inflammatory response after SCI poses challenges to its repair. Immune remodeling significantly affects stem cell survival and differentiation after transplantation and the prognosis of SCI. Immunological reconstruction strategies based on biomaterials have shown promising results and offer potential for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jinhua Xu, Jingjing Li, Guofeng Wu, Yajun Ren, Xue Wang, Qianyun Zhang
Summary: The study evaluated the effects of pemetrexed combined with cisplatin on the immune system of NSCLC patients. The results showed that patients treated with pemetrexed plus cisplatin had higher levels of interferon-γ and tumor necrosis factor-alpha, and lower levels of CD4+ T cells and tumor markers compared to those treated with docetaxel plus cisplatin.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Biochemistry & Molecular Biology
Jun-Yan Li, Yu-Pei Chen, Ying-Qin Li, Na Liu, Jun Ma
Summary: The development of immune checkpoint blockade-based immunotherapy has changed cancer treatment methods significantly, although not all patients can benefit from it. Conventional chemotherapy and targeted therapy can enhance antitumor immune responses, providing a theoretical basis for combination therapy with ICBs, but the optimal treatment regimens still need further exploration.
Article
Environmental Sciences
Yun Zhao, Linqing Wei, Abderrahmane Tagmount, Alex Loguinov, Amin Sobh, Alan Hubbard, Cliona M. McHale, Christopher J. Chang, Chris D. Vulpe, Luoping Zhang
Summary: This study identified genes affecting formaldehyde toxicity in human hematopoietic cells using CRISPR screening, including those that increase sensitivity and resistance, along with related pathways and mechanisms. Results indicated a significant role for formaldehyde metabolism and the Fanconi anemia pathway in toxicity tolerance, and new network analyses revealed potential roles for one-carbon metabolism, fatty acid synthesis, and mTOR signaling in modulating formaldehyde toxicity.
Article
Genetics & Heredity
L. Dold, L. Zimmer, C. Schwarze-Zander, C. Boesecke, R. Mohr, J. -C. Wasmuth, K. Ommer, B. Gathof, B. Kraemer, J. Nattermann, C. P. Strassburg, J. K. Rockstroh, U. Spengler, B. Langhans
Summary: HLA-B*57 affects the course of HIV infection by modifying inflammatory subsets of NK cells and monocytes, leading to enhanced responsiveness of these innate immune cells to TLR ligands, potentially contributing to increased vulnerability in sepsis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Yu Cao, Jingzhu Gao, Lihua Zhang, Ningbo Qin, Beiwei Zhu, Xiaodong Xia
Summary: The study showed that JSP supplementation alleviated symptoms of colitis, increased colon length, protected goblet cells, and improved intestinal epithelial integrity and permeability in mice.
Article
Chemistry, Multidisciplinary
Alexandra Atalis, Mark C. Keenum, Bhawana Pandey, Alexander Beach, Pallab Pradhan, Casey Vantucci, Laura O'Farrell, Richard Noel, Ritika Jain, Justin Hosten, Clinton Smith, Liana Kramer, Angela Jimenez, Miguel Armenta Ochoa, David Frey, Krishnendu Roy
Summary: Molecular adjuvants targeting pattern recognition receptors (PRRs) on antigen-presenting cells (APCs) delivered on nanoparticles (NPs) along with a stabilized spike protein antigen could stimulate broad and efficient immune responses against SARS-CoV-2. Combination adjuvant-NPs simultaneously targeting TLR and RIG-I receptors differentially induced T cell proliferation and increased proinflammatory cytokine secretion by APCs in vitro. In vivo studies showed that the adjuvant-NPs enhanced immune responses, including the generation of memory T cells and antibody production.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Zhangchi Dongye, Jian Li, Yuzhang Wu
Summary: Tremendous progress has been made in tumour immunotherapy with the development of combination therapy strategies targeting immunosuppressive signaling pathways. TLR9 agonists have been extensively studied as treatment for cancer, infectious diseases, and allergies. CpG-ODN, a commonly used TLR9 agonist, can stimulate antigen-presenting cells in the tumour microenvironment to initiate immune responses. Combination therapies co-delivering CpG-ODN with other therapeutics have shown promising results in animal models and early human clinical trials.
BRITISH JOURNAL OF CANCER
(2022)
Article
Fisheries
Shipo Li, Xing Heng, Liyun Guo, Duncan James Lessing, Weihua Chu
Summary: Dietary short chain fatty acids (SCFAs) can enhance antioxidant capacity and immune responses in crucian carp, promoting the expression of immune-related genes and tight junction protein genes, thus improving disease resistance in the host.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Oncology
Ti Yang, Yurong Luo, Junhao Liu, Fang Liu, Zengxin Ma, Gai Liu, Hailiang LI, Jianfan Wen, Chengcong Chen, Xiancheng Zeng
Summary: A new signature incorporating immune and lipid metabolism-related markers was developed and validated to assess the prognosis and immune status of LIHC patients. This signature can be used for survival prediction, individualized chemotherapy, and immunotherapeutic guidance. Additionally, potential targeted therapeutics and novel ideas for the immune evasion and progression of LIHC were provided.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Elisabetta Schiavello, Veronica Biassoni, Giovanna Gattuso, Marta Podda, Stefano Chiaravalli, Francesco Barretta, Manila Antonelli, Loris De Cecco, Emilia Pecori, Lorenza Gandola, Maura Massimino
Summary: This is a small series of homogeneously-treated DMG patients with H3K27M mutation. The treatment approach is similar to DIPG and the results obtained are comparable with those of DIPG patients. Therefore, these DMG patients should be included in registries and protocols of DIPG.
Article
Oncology
Milena Perrone, Claudia Chiodoni, Mara Lecchi, Laura Botti, Barbara Bassani, Annamaria Piva, Elena Jachetti, Matteo Milani, Daniele Lecis, Elda Tagliabue, Paolo Verderio, Sabina Sangaletti, Mario P. Colombo
Summary: Cancer can reprogram the bone marrow niche through the BM mesenchymal stem cells (MSC) and IL-1B/ATF3 signaling pathway, which promotes myeloid cell differentiation and tumor development. The expression of CD11b thorn population in the peripheral blood can be used as a potential biomarker for early diagnosis of breast cancer. This study suggests that targeting IL-1B or ATF3 may have therapeutic benefits for breast cancer patients.
Article
Biochemistry & Molecular Biology
Valentino Le Noci, Giancarla Bernardo, Giacomo Manenti, Gabriele Infante, Dariush Khaleghi Hashemian, Lucia Minoli, Simone Canesi, Francesca Bianchi, Tiziana Triulzi, Stefania Arioli, Loris De Cecco, Simone Guglielmetti, Federico Ambrogi, Camilla Recordati, Nicoletta Gagliano, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini
Summary: This study explores the impact of perturbing lung microbiota on lung cancer development by using antibiotics or probiotic aerosol. The results suggest that L.RGG aerosol can reduce tumor nodules and Tregs in the lung, while increasing the expression of immunoglobulin joining chain and promoting B and CD4 T cell infiltration. This non-invasive strategy shows efficacy in impairing lung cancer growth by promoting local immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Maria F. Ianno, Veronica Biassoni, Elisabetta Schiavello, Andrea Carenzo, Luna Boschetti, Lorenza Gandola, Barbara Diletto, Edoardo Marchesi, Claudia Vegetti, Alessandra Molla, Christof M. Kramm, Dannis G. van Vuurden, Patrizia Gasparini, Francesca Gianno, Felice Giangaspero, Piergiorgio Modena, Brigitte Bison, Andrea Anichini, Sabina Vennarini, Emanuele Pignoli, Maura Massimino, Loris De Cecco
Summary: This study demonstrates for the first time that circulating nucleic acids in the blood can serve as powerful and easy-to-assay molecular markers for the disease status of diffuse intrinsic pontine glioma (DIPG), providing valuable prognostic information.
Article
Oncology
Giancarla Bernardo, Valentino Le Noci, Emerenziana Ottaviano, Loris De Cecco, Chiara Camisaschi, Simone Guglielmetti, Martina Di Modica, Giorgio Gargari, Francesca Bianchi, Serena Indino, Patrizia Sartori, Elisa Borghi, Michele Sommariva, Elda Tagliabue, Tiziana Triulzi, Lucia Sfondrini
Summary: This study highlights the significant influence of mammary tumor microbiota on local immune status and the relevance of its treatment with antibiotics, in combination with breast cancer therapies.
Review
Biochemistry & Molecular Biology
Nadia Zaffaroni, Giovanni L. L. Beretta
Summary: Pyroptosis is a programmed cell death characterized by the rupture of the plasma membranes and release of cellular content leading to inflammatory reaction. Four cellular mechanisms inducing pyroptosis have been reported thus far. Pyroptosis plays roles in tumor initiation, progression, metastasis, treatment response, and patient outcome. Induction of pyroptosis has been reported in several tumor types following antitumor therapies, including melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Amelia Barcellini, Alexandra Charalampopoulou, Loris De Cecco, Andrei Fodor, Emanuela Rabaiotti, Giorgio Candotti, Simona Secondino, Angelica Facoetti, Laura Deborah Locati, Sandro Pignata, Ester Orlandi, Giorgia Mangili
Summary: Radiotherapy is increasingly being used in combination with surgery, chemotherapy, and novel drugs to treat ovarian cancer. This review aims to summarize the current understanding of the radiosensitivity and radioresistance of ovarian cancer, which is the deadliest gynecological cancer worldwide. Understanding the mechanisms of radiosensitivity and identifying potential biomarkers of radioresistance could be crucial in guiding clinical decision-making, considering the high rate of recurrence in and out of the radiotherapy fields, especially in the era of personalized oncology.
Article
Biochemistry & Molecular Biology
Marika A. Franczak, Oliwia Krol, Gabriela Harasim, Agata Jedrzejewska, Nadia Zaffaroni, Carlotta Granchi, Filippo Minutolo, Amir Avan, Elisa Giovannetti, Ryszard T. Smolenski, Godefridus J. Peters
Summary: Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. In this study, the cytotoxicity of new inhibitors of glucose transporter type 1 (GLUT-1) and lactate dehydrogenase-A (LDH-A) in relation to ATP/NAD+ metabolism, glycolysis and mitochondrial respiration was investigated. The inhibitors showed cytotoxicity in MM cells, associated with a decrease in ATP and NAD+, and were most effective in cells with the highest metabolic modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosue Scognamiglio, Michele Del Sesto, Germana Tognon, Daniela Califano, Clorinda Schettino, Paolo Chiodini, Francesco Perrone, Delia Mezzanzanica, Sandro Pignata, Antonella Tomassetti
Summary: The membrane expression of EGFR can serve as a prognostic biomarker in ovarian cancer patients and is associated with the efficacy of anti-angiogenic therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Silvia Gobbi, Silvia Martini, Riccardo Rozza, Angelo Spinello, Jessica Caciolla, Angela Rampa, Federica Belluti, Nadia Zaffaroni, Alessandra Magistrato, Alessandra Bisi
Summary: In this study, novel compounds with dual AR and ER activity were designed by modifying flavonoid-related compounds. Compounds 3b and 4a showed promising submicromolar activity against both targets. Computational studies confirmed the feasibility of using multi-target approaches for ER+ BC treatment. The homoisoflavone core emerged as a valuable scaffold for the design of multifunctional compounds.
Review
Cell Biology
Giancarla Bernardo, Valentino Le Noci, Martina Di Modica, Elena Montanari, Tiziana Triulzi, Serenella M. Pupa, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini
Summary: Emerging evidence suggests that the composition of the gut microbiota is closely associated with breast cancer progression. In addition to their role in modulating the immune response and estrogen levels, recent research has revealed the presence of microbes in the breast tissue, which was once considered sterile, and their potential contribution to tumor progression. Specific bacterial species enriched in breast tumors have been identified, and their mechanisms of influencing cancer progression have been elucidated. Understanding the crosstalk between the gut/mammary microbiota and breast cancer holds promise for developing innovative therapeutic approaches.
Letter
Surgery
Armando G. Licata, Chiara M. Ciniselli, Luca Sorrentino, Arianna Micali, Maria Grazia Daidone, Marcello Guaglio, Manuela Gariboldi, Paolo Verderio, Loris De Cecco, Maurizio Cosimelli
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Oncology
N. A. Iacovelli, T. Rancati, R. Ingargiola, S. Alfieri, L. De Cecco, F. Badenchini, A. Cavallo, A. Cicchetti, N. Zaffaroni, V. Doldi, E. Mancinelli, M. S. Serafini, A. Devecchi, R. Valdagni, E. Orlandi
RADIOTHERAPY AND ONCOLOGY
(2022)
Meeting Abstract
Oncology
P. Zeng, M. Cecchini, J. Barrett, M. Shammas-Toma, L. De Cecco, M. Serafini, S. Cavalieri, L. Licitra, F. Hoebers, R. Brakenhoff, C. Leemans, K. Scheckenbach, T. Poli, X. Wang, X. Liu, F. Laxague, E. Prisman, C. Poh, P. Bose, J. Dort, M. Shaikh, S. Ryan, A. Dawson, M. Khan, C. Howlett, W. Stecho, P. Plantinga, S. da Silva, M. Hier, H. Khan, D. MacNeil, A. Mendez, J. Yoo, K. Fung, P. Lang, E. Winquist, D. Palma, H. Ziai, S. Li, P. Boutros, J. Mymryk, A. Nichols
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)