Journal
CANCER RESEARCH
Volume 70, Issue 17, Pages 6687-6691Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-10-1383
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Funding
- Swedish Cancer Society
- Swedish Research Council
- Swedish Childhood Cancer Society
- Stockholm Cancer Foundation
- Olle Engkvist's Foundation
- Karolinska Institutet
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Intrinsic tumor-suppressor pathways protect healthy cells from transformation by activated oncogenes like MYC or RAS through induction of apoptosis or cellular senescence, respectively. However, when expressed together, MYC and RAS evade these barriers and initiate tumorigenesis. Although Ras suppresses Myc-induced apoptosis, the role of Myc in this cooperation has remained undefined. In a recent report, we showed that Myc represses Ras-induced senescence, thereby overcoming the second major barrier of tumorigenesis. Inhibition of Ras-induced senescence required specific phosphorylation of Myc by cyclin-dependent kinase 2 (Cdk2) and was abrogated by pharmacologic Cdk2 inhibitors, urging a reevaluation of this kinase as a therapeutic target in Myc- or Ras-driven tumors. Cancer Res; 70(17); 6687-91. (C)2010 AACR.
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