Review
Neurosciences
Xiang Wang, Xinghang Chen, Zhuohui Chen, Mengqi Zhang
Summary: This review discusses the relationship between large artery calcification and the risk, prognosis, treatment response, and prevention of stroke, as well as the possible mechanisms behind these associations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Orthopedics
I. Hellberg, V. -P. Karjalainen, M. A. J. Finnilä, E. Jonsson, A. Turkiewicz, P. Önnerfjord, V. Hughes, J. Tjörnstrand, M. Englund, S. Saarakkala
Summary: This study proposed a micro-computed tomography (mu CT) based 3D analysis of meniscal calcifications ex vivo, including a new grading system. The results showed that mu CT images can effectively depict meniscal calcifications, and the new grading system can accurately measure the severity of meniscal calcification. Two different patterns of degeneration were observed.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria T. A. Wetscherek, Edwina McNaughton, Veronika Majcher, Andreas Wetscherek, Timothy J. Sadler, Ahmed Alsinbili, Wen Hui Teh, Samuel D. Moore, Nirav Patel, William P. W. Smith, Unni Krishnan
Summary: This study assessed coronary artery calcification (CAC) on non-contrast non-ECG-gated CT thorax (NC-NECG-CTT) and found that the presence and severity of CAC correlates with short-term cardiovascular events and death.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Mitsuteru Yoshida, Kazuya Kondo, Naoki Miyamoto, Yukikiyo Kawakami, Akira Tangoku
Summary: Calcification in thymomas is associated with the invasiveness of tumors to surrounding organs and tissues, and may predict the stage and high-risk histology of thymomas. This could help in deciding therapeutic methods and surgical approaches based on the calcification status observed from CT findings.
Article
Health Care Sciences & Services
Annelotte Vos, Aryan Vink, Remko Kockelkoren, Richard A. P. Takx, Csilla Celeng, Willem P. T. M. Mali, Ivana Isgum, Ronald L. A. W. Bleys, Pim A. de Jong
Summary: This study investigated the detection and characterization of arterial calcifications in leg arteries using radiography and computed tomography (CT) and compared them with histology. The results showed that both radiography and CT could detect the majority of calcifications, but missed some mild calcifications. There was a moderate agreement between radiography/CT and histology in determining the location of calcifications in the intima or media of the arteries.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Sang Oh, Tae Hoon Kim, Ji Won Kim, Juyeon Yang, Hye Sun Lee, Jae-Hoon Lee, Chul Hwan Park
Summary: This study investigated the feasibility and limitations of using deep learning-based coronary calcium scoring in PET-CT compared to ECG-gated non-contrast-enhanced CaCT. Results showed that PET-CT with AI-assisted CACS measurements had comparable results to CACS in coronary calcium CT. However, there were concerns about the relatively high false-negative results and tendency to underestimate.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Cornelia D. Cudrici, Kam A. Newman, Elisa A. Ferrante, Rebecca Huffstutler, Katherine Carney, Blas Betancourt, Markku Miettinen, Richard Siegel, James D. Katz, Leon J. Nesti, Cynthia St Hilaire, Deepak Lakshmipathy, Han Wen, Mohammad H. Bagheri, Manfred Boehm, Alessandra Brofferio
Summary: This study describes erosive peripheral arthropathy and axial enthesopathic calcifications in ACDC patients over an 11-year period, and identifies the composition of periarticular calcifications and synovial fluid crystals for the first time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix G. Gassert, Claudio E. Schacky, Christina Mueller-Leisse, Florian T. Gassert, Gregor Pahn, Karl-Ludwig Laugwitz, Marcus R. Makowski, Jonathan Nadjiri
Summary: The objective of this study was to evaluate the accuracy of coronary artery calcium scoring from virtual non-contrast imaging generated from spectral data compared to standard non-contrast imaging in a patient cohort with clinically approved software. The results showed that there was an underestimation of CACS in VNC images compared to TNC images, but after correction, they were in good agreement with the standard technique. This could potentially enable radiation dose reductions in clinical diagnostics of coronary artery disease.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Krista Nuotio, Suvi M. Koskinen, Laura Makitie, Jarno Tuimala, Petra Ijas, Hanna M. Heikkila, Jani Saksi, Pirkka Vikatmaa, Pia Sorto, Sonja Kasari, Ilari Paakkari, Heli Silvennoinen, Leena Valanne, Mikko I. Mayranpaa, Lauri Soinne, Petri T. Kovanen, Perttu J. Lindsberg
Summary: The study found that long-term use of the anticoagulant warfarin may lead to calcification of carotid atherosclerotic plaques, particularly in locations known to cause stroke. This highlights the importance of further research into the potential adverse effects of anticoagulant drugs.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshimi Anzai, Chun-Pin Chang, Kerry Rowe, John Snyder, Vikrant Deshmukh, Michael Newman, Alison Fraser, Ken Smith, Ankita Date, Carlos Galvao, Marcus Monroe, Mia Hashibe
Summary: This study found that surveillance imaging in patients with head and neck cancer is associated with lower mortality. Specifically, for regionalized or distant squamous cell carcinoma, surveillance imaging was associated with a lower risk of death.
Article
Cardiac & Cardiovascular Systems
Young-Hyun Lee, Sung Mok Kim, Eun Kyoung Kim, Sung-Ji Park, Sang-Chol Lee, Seung Woo Park, Dong Seop Jeong, Sung -A Chang
Summary: This study investigated how the pattern and amount of pericardial calcification affect mid-term clinical outcomes after pericardiectomy to treat constrictive pericarditis. The results showed that patients with a lower burden of pericardial calcification had a higher rate of mid-term clinical events after surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kenji Kawai, Yu Sato, Jason Y. Hokama, Rika Kawakami, Takao Konishi, Saikat Kumar B. Ghosh, Renu Virmani, Aloke Finn
Summary: In this study, the histologic effects of intravascular lithotripsy (IVL) on coronary calcified lesions were examined. IVL demonstrated a superior fracturing effect on coronary calcified lesions compared with plain old balloon angioplasty (POBA). Optical coherence tomography (OCT) failed to identify the presence of some calcium fractures and underestimated the depth of fracture when compared with micro-computed tomography (CT).
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Oncology
Rustain L. Morgan, Megan M. Eguchi, Jessica McDermott, Adam C. Mueller, Arya Amini, Julie A. Goddard, Premal S. Trivedi, Sana D. Karam
Summary: The study found that posttreatment imaging with PET was associated with improved survival in patients with advanced laryngeal carcinoma compared to CT imaging. There was a trend towards improved cancer-specific survival in patients with oral cavity or oropharyngeal malignancies who underwent PET/CT imaging, but it did not reach statistical significance.
Article
Cardiac & Cardiovascular Systems
Ezequiel Guzzetti, Jin Kyung Oh, Mylene Shen, Marc R. Dweck, Kian Keong Poh, Amr E. Abbas, Ramy Mando, Gregg S. Pressman, Daniel Brito, Lionel Tastet, Tania Pawade, Mariano Luis Falconi, Diego Perez de Arenaza, William Kong, Edgar Tay, Philippe Pibarot, Jae-Kwan Song, Marie-Annick Clavel
Summary: This study aimed to validate the accuracy of sex-specific thresholds of aortic valve calcification (AVC) in Asians. The results showed that the AVC thresholds defining severe aortic stenosis (AS) were comparable between Asian and Caucasian populations, and similar to those proposed in the guidelines. However, the accuracy of AVC to identify severe AS, especially in Asian women, was sub-optimal. Therefore, the use of AVC-density is preferable in Asians.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofang Ban, Zhaoyue Li, Yuchen Duan, Ke Xu, Jie Xiong, Yingfeng Tu
Summary: This article reviews advanced techniques for coronary artery calcification imaging and their potential applications in both experimental and clinical settings, which provide the ability for early and accurate assessment of calcium content in atherosclerotic plaques.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Microbiology
Nadine Fornelos, Eric A. Franzosa, Jason Bishai, John W. Annand, Akihiko Oka, Jason Lloyd-Price, Timothy D. Arthur, Ashley Garner, Julian Avila-Pacheco, Henry J. Haiser, Andrew C. Tolonen, Jeffrey A. Porter, Clary B. Clish, R. Balfour Sartor, Curtis Huttenhower, Hera Vlamakis, Ramnik J. Xavier
NATURE MICROBIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Satoshi Kotani, Nobuhiko Fukuba, Kousaku Kawashima, Yoshiyuki Mishima, Hiroki Sonoyama, Eiko Okimoto, Yasumasa Tada, Akihiko Oka, Yuji Tamagawa, Naoki Oshima, Tsuyoshi Mishiro, Hiroshi Tobita, Kotaro Shibagaki, Ichiro Moriyama, Norihisa Ishimura, Yoshinori Kushiyama, Hirofumi Fujishiro, Shunji Ishihara
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
David C. Montrose, Ryohei Nishiguchi, Srijani Basu, Hannah A. Staab, Xi Kathy Zhou, Hanhan Wang, Lingsong Meng, Melanie Johncilla, Juan R. Cubillos-Ruiz, Diana K. Morales, Martin T. Wells, Kenneth W. Simpson, Shiying Zhang, Belgin Dogan, Chen Jiao, Zhangjun Fei, Akihiko Oka, Jeremy W. Herzog, R. Balfour Sartor, Andrew J. Dannenberg
Summary: Excessive dietary fructose consumption exacerbates colitis by altering the composition, distribution, and metabolic function of resident enteric microbiota, leading to increased access of gut luminal microbes to the colonic mucosa, reduced protective commensal microbes, and increased luminal conjugated bile acids, all of which worsen colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Hiroshi Tobita, Tomotaka Yazaki, Masatoshi Kataoka, Satoshi Kotani, Akihiko Oka, Tsuyoshi Mishiro, Naoki Oshima, Kousaku Kawashima, Norihisa Ishimura, Kohji Naora, Shuichi Sato, Shunji Ishihara
Summary: The efficacy of SGLT2i and DPP4i in NAFLD patients without type 2 diabetes mellitus has not been previously reported. This study found that both dapagliflozin and teneligliptin treatment significantly reduced serum ALT levels in these patients, with dapagliflozin specifically leading to weight loss related to changes in body water and fat mass.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Multidisciplinary Sciences
Daniel van der Lelie, Akihiko Oka, Safiyh Taghavi, Junji Umeno, Ting-Jia Fan, Katherine E. Merrell, Sarah D. Watson, Lisa Ouellette, Bo Liu, Muyiwa Awoniyi, Yunjia Lai, Liang Chi, Kun Lu, Christopher S. Henry, R. Balfour Sartor
Summary: Environmental factors, mucosal permeability, and defective immunoregulation contribute to overactive immunity towards certain intestinal bacteria, leading to various inflammatory conditions. GUT-108 expands beneficial gut bacteria, reduces pathogens, promotes mucosal healing and immune regulation.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Akihiko Oka, Norihisa Ishimura, Shunji Ishihara
Summary: Artificial intelligence (AI) is rapidly becoming a crucial tool in the medical field, especially in early cancer detection and precision medicine. This review focuses on the applications of AI technology in gastroenterology, hepatology, and pancreatology.
Article
Medicine, General & Internal
Tomotaka Yazaki, Ichiro Moriyama, Hiroshi Tobita, Hiroki Sonoyama, Eiko Okimoto, Akihiko Oka, Yoshiyuki Mishima, Naoki Oshima, Kotaro Shibagaki, Kousaku Kawashima, Norihisa Ishimura, Taichi Nagami, Riruke Maruyama, Hiroaki Shiina, Shunji Ishihara
Summary: Immune checkpoint inhibitors (ICIs) have anti-tumor effects but can also result in a variety of immune-related adverse events (irAEs). This rare case report describes a patient with renal cell carcinoma who developed acute pancreatitis and colitis simultaneously as irAEs during nivolumab treatment, and showed significant improvement with corticosteroid therapy.
Article
Nutrition & Dietetics
Esmat Rousta, Akihiko Oka, Bo Liu, Jeremy Herzog, Aadra P. Bhatt, Jeremy Wang, Mohammad B. Habibi Najafi, Ryan Balfour Sartor
Summary: The study found that commonly used synthetic dietary emulsifiers have different effects on intestinal inflammation: CMC exacerbates inflammation, while P80 affects specific microbiota populations.
Article
Gastroenterology & Hepatology
Kousaku Kawashima, Naoki Oshima, Kenichi Kishimoto, Masatoshi Kataoka, Mai Fukunaga, Satoshi Kotani, Hiroki Sonoyama, Akihiko Oka, Yoshiyuki Mishima, Hideaki Kazumori, Noriyoshi Ishikawa, Asuka Araki, Shunji Ishihara
Summary: This study aimed to determine the optimal FC cutoff value for predicting HH in UC patients and investigate FC's predictability for prolonged CR. The results showed that FC levels < 82 μg/g can predict HH in UC patients with clinical and endoscopic remission, and low FC also leads to prolonged CR.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pathology
Tsuyoshi Mishiro, Kotaro Shibagaki, Chika Fukuyama, Masatoshi Kataoka, Takumi Notsu, Noritsugu Yamashita, Akihiko Oka, Mamiko Nagase, Asuka Araki, Kousaku Kawashima, Norihisa Ishimura, Riruke Maruyama, Yoshikazu Kinoshita, Shunji Ishihara
Summary: With the decrease in Helicobacter pylori-infected individuals, the occurrence of gastric neoplasms in H. pylori-naive patients, such as sporadic foveolar-type gastric adenoma (FGA), has been increasing. This study investigated the genomic features of sporadic FGA and identified a novel single-nucleotide variation (SNV) in the KLF4 gene that may contribute to the slow-growing properties of this neoplasm.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara Federici, Sharon Kredo-Russo, Rafael Valdes-Mas, Denise Kviatcovsky, Eyal Weinstock, Yulia Matiuhin, Yael Silberberg, Koji Atarashi, Munehiro Furuichi, Akihiko Oka, Bo Liu, Morine Fibelman, Iddo Nadav Weiner, Efrat Khabra, Nyssa Cullin, Noa Ben-Yishai, Dana Inbar, Hava Ben-David, Julian Nicenboim, Noga Kowalsman, Wolfgang Lieb, Edith Kario, Tal Cohen, Yael Friedman Geffen, Lior Zelcbuch, Ariel Cohen, Urania Rappo, Inbar Gahali-Sass, Myriam Golembo, Vered Lev, Mally Dori-Bachash, Hagit Shapiro, Claudia Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, Danping Zheng, Samuel Philip Nobs, Jotham Suez, Noa Stettner, Alon Harmelin, Naomi Zak, Sailaja Puttagunta, Merav Bassan, Kenya Honda, Harry Sokol, Corinna Bang, Andre Franke, Christoph Schramm, Nitsan Maharshak, Ryan Balfour Sartor, Rotem Sorek, Eran Elinav
Summary: A clade of Klebsiella pneumoniae strains has been found to be strongly associated with exacerbation and severity of inflammatory bowel diseases. By generating a lytic five-phage combination targeting these strains, effective suppression of the bacteria and attenuation of inflammation can be achieved.
Article
Microbiology
Colin Buttimer, Tom Sutton, Joan Colom, Ellen Murray, Pedro H. Bettio, Linda Smith, Andrei S. Bolocan, Andrey Shkoporov, Akihiko Oka, Bo Liu, Jeremy W. Herzog, R. Balfour Sartor, Lorraine A. Draper, R. Paul Ross, Colin Hill
Summary: The study found that while phages can effectively reduce the population of host bacteria in in vitro models, this effect did not translate to a similar outcome in in vivo settings. This is likely due to a reduction in phage numbers during transit of the mouse GIT.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Taku Kobayashi, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Takayuki Abe, Tadakazu Hisamatsu, Japanese UC Study Grp
Summary: Most first-use advanced therapies were effective for patients with acute severe ulcerative colitis, while second-use advanced therapies might have had limited benefits in inducing clinical remission. These findings may provide insights for the management of hospitalized patients.
JOURNAL OF GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Shiying Zhang, Xochitl Morgan, Belgin Dogan, Francois-Pierre J. Martin, Suzy Strickler, Akihiko Oka, Jeremy Herzog, Bo Liu, Scot E. Dowd, Curtis Huttenhower, Matthieu Pichaud, Esra Dogan, Randy Longman, Rhonda Yantiss, Lukas A. Mueller, Ellen J. Scherl, R. Balfour Sartor, Kenneth W. Simpson
Article
Nutrition & Dietetics
Na Cha, Naoki Oshima, Kenichi Kishimoto, Satoshi Kotani, Eiko Okimoto, Tomotaka Yazaki, Hiroki Sonoyama, Akihiko Oka, Yoshiyuki Mishima, Kotaro Shibagaki, Hiroshi Tobita, Kousaku Kawashima, Norihisa Ishimura, Shunji Ishihara
Summary: This study examined the impact of oral tacrolimus (TAC) on renal function in patients with ulcerative colitis (UC) undergoing remission induction therapy. The results showed that although TAC was effective in inducing remission in both elderly and non-elderly patients, a decline in estimated glomerular filtration rate (eGFR) was observed in almost all patients, with a maximum change of -34.4% from baseline at week 11. The decline in eGFR recovered quickly after TAC discontinuation, but did not return to baseline at two years following cessation of treatment. Age and peak serum trough level during TAC treatment significantly influenced the rate of eGFR change. Elderly patients experienced a greater decline in eGFR compared to non-elderly patients, and the difference in eGFR decline rate persisted at two years after treatment withdrawal. Therefore, careful monitoring of renal function and close attention to eGFR changes are important in UC patients receiving oral TAC, particularly in elderly patients after treatment cessation.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2022)