Article
Biochemistry & Molecular Biology
Gaochao Lv, Yinxing Miao, Yinfei Chen, Chunmei Lu, Xiuting Wang, Minhao Xie, Ling Qiu, Jianguo Lin
Summary: The expression level of PD-L1 is a reproducible biomarker for guiding patient stratification in immunotherapy. A novel small-molecular radiotracer [F-18]LG-1 based on biphenyl active structure was developed in this study, showing great potential as a promising PD-L1 radiotracer for accurately evaluating PD-L1 expression in tumors.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Hannah E. Greenwood, Richard Edwards, Norman Koglin, Mathias Berndt, Friedrich Baark, Jana Kim, George Firth, Eman Khalil, Andre Mueller, Timothy H. Witney
Summary: Amino acid utilization is perturbed in cancer cells, which can be diagnosed through positron emission tomography imaging. This study synthesized a radiolabeled amino acid [F-18]FRPG and evaluated its tumor imaging properties.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michel Koole, Donatienne Van Weehaeghe, Kim Serdons, Marissa Herbots, Christopher Cawthorne, Sofie Celen, Frederick A. Schroeder, Jacob M. Hooker, Guy Bormans, Jan de Hoon, Janice E. Kranz, Koen Van Laere, Tonya M. Gilbert
Summary: HDAC6 is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibiting HDAC6 deacetylase activity shows beneficial effects in disease models. This study evaluated the brain binding of [F-18]EKZ-001 in healthy adults, showing that it is safe for quantifying HDAC6 expression and that males have higher HDAC6 expression compared to females.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Isabella Silins, Anders Sundin, Patrik Nordeman, Mahabuba Jahan, Sergio Estrada, Azita Monazzam, Mark Lubberink, Franklin Aigbirhio, Per Hellman, Gunnar Antoni
Summary: The study demonstrates that the fluorine-18 etomidate analogue, [F-18]CETO, shows high specificity in binding to the adrenal cortex in both human and animal tissues. Compared to [C-11]MTO, it exhibits lower non-specific uptake in the liver of NHP. This makes [F-18]CETO a promising PET tracer for imaging adrenocortical disease, warranting further evaluation in humans.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Waelti, Stephan Skawran, Thomas Sartoretti, Moritz Schwyzer, Antonio G. Gennari, Cacilia Mader, Valerie Treyer, Christian J. Kellenberger, Irene A. Burger, Thomas Hany, Alexander Maurer, Martin W. Huellner, Michael Messerli
Summary: This study retrospectively assessed the evolution of administered radiotracer activity for F-18-fluorodeoxyglucose PET/CT or PET/MR in pediatric patients between 2000 and 2021. The results showed that children have benefited from a significant reduction in the administered F-18-FDG dose over the past 20 years without compromising objective image quality.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Laura Evangelista, Francesco Giacomuzzi, Fernando Di Gregorio, Marco Rensi
Summary: A 68-year-old woman with a history of hepatocellular cancer underwent F-18-choline PET/CT due to a rapid increase in alpha-fetoprotein levels, which showed multiple uptakes in the skeletal muscles indicating disease recurrence. Careful interpretation and multidisciplinary discussion are essential in evaluating F-18-choline PET/CT findings in this type of cancer.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
David Sipos, Zoltan Laszlo, Zoltan Toth, Peter Kovacs, Jozsef Tollar, Akos Gulyban, Ferenc Lakosi, Imre Repa, Arpad Kovacs
Summary: This study investigated the added value of FDOPA PET in radiotherapy planning for GBM and found that FDOPA PET resulted in larger tumor volumes compared to MRI, but most recurrences still occurred within the prescribed dose level.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lisbeth Marner, Michael Lundemann, Astrid Sehested, Karsten Nysom, Lise Borgwardt, Rene Mathiasen, Peder S. Wehner, Otto M. Henriksen, Carsten Thomsen, Jane Skjoth-Rasmussen, Helle Broholm, Olga Ostrup, Julie L. Forman, Liselotte Hojgaard, Ian Law
Summary: The study found that adding [F-18]FET PET to MRI in pediatric CNS tumor patients significantly improved diagnostic accuracy, especially in treated lesions. This combination imaging technique helps differentiate tumor from non-tumor lesions more effectively, with a substantial impact on clinical management and decision-making.
Article
Biochemistry & Molecular Biology
Isaac M. Jackson, Mackenzie L. Carlson, Corinne Beinat, Noeen Malik, Mausam Kalita, Samantha Reyes, E. Carmen Azevedo, Sydney C. Nagy, Israt S. Alam, Rishi Sharma, Santiago Appiani La Rosa, Farshad Moradi, Jeffrey Cleland, Bin Shen, Michelle L. James
Summary: Positron emission tomography (PET) is a powerful tool for studying neuroinflammatory diseases, but current PET biomarkers have limitations. The dendrimer PET tracer [F-18]OP-801 shows promise selectively targeting reactive microglia and macrophages. Further characterization and optimization of [F-18]OP-801, including clinical radiosynthesis, stability, and dosimetry, enable its clinical translation for imaging neuroinflammation in humans.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Songye Li, Mika Naganawa, Richard Pracitto, Soheila Najafzadeh, Daniel Holden, Shannan Henry, David Matuskey, Paul R. Emery, Zhengxin Cai, Jim Ropchan, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang
Summary: The study demonstrated that [F-18]SynVesT-1 has excellent imaging and binding properties in humans, with fast and high brain uptake, appropriate tissue kinetics, high levels of specific binding, and excellent test-retest reproducibility. Therefore, [F-18]SynVesT-1 is proven to be a favorable radiotracer for SV2A imaging and quantification in humans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Luca Filippi, Oreste Bagni, Ermanno Notarianni, Adelchi Saltarelli, Cesare Ambrogi, Orazio Schillaci
Summary: The study aimed to assess the role of PET/CT in hepatocellular carcinoma (HCC) patients and found that PET/CT had a significant impact on clinical management and patients' overall survival.
Article
Biochemistry & Molecular Biology
Sebastien Bergeret, Cristina Birzu, Pierre Meneret, Alain Giron, Sophie Demeret, Clemence Marois, Louis Cousyn, Laura Rozenblum, Alice Laurenge, Agusti Alentorn, Vincent Navarro, Dimitri Psimaras, Aurelie Kas
Summary: This study retrospectively analyzed FDG PET results of patients diagnosed with autoimmune encephalitis (AE) between 2015 and 2020. The study found that 98% of patients showed abnormal PET results, displaying higher sensitivity compared to MRI (53%). The most frequent abnormalities were medial temporal lobe and/or striatum hypermetabolism, cortical hypometabolism, and cerebellum abnormalities. LGI1 AE showed more frequent medial temporal lobe hypermetabolism, while NMDAR AE showed widespread cortical hypometabolism. GAD AE showed fewer abnormalities. Striatum hypermetabolism was more frequent in patients treated for less than 1 month, suggesting a relation to disease activity.
Article
Otorhinolaryngology
Mine Araz, Demet Nak, Cigdem Soydal, Elif Peker, Ilhan Erden, N. Ozlem Kucuk
Summary: The study demonstrates that 18F-FCH PET/MR is highly effective in preoperatively localizing parathyroid adenomas, even when 18F-FCH PET/CT is negative. Neck MR alone is insufficient in detecting parathyroid adenomas, but combining PET/MR helps in precise localization.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Vesa Oikonen, Hidehiro Iida, Pirjo Nuutila, Ele Ferrannini
Summary: This study aimed to assess whether [18F]FDG-PET can be used in the study of renal glucose metabolism in humans. The results showed that [18F]FDG-PET can still provide relevant physiological information on regional renal glucose uptake, as long as [18F]FDG uptake is corrected for tubular radioactivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Gentzsch, Xinyu Chen, Philipp Spatz, Urban Kosak, Damijan Knez, Naoko Nose, Stanislav Gobec, Takahiro Higuchi, Michael Decker
Summary: In this study, a selective and reversible PET tracer targeting AD diagnosis was successfully synthesized, labeled with F-18, and demonstrated promising activity and binding potential in in vitro experiments.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Review
Oncology
Eric O. Aboagye, Tara D. Barwick, Uwe Haberkorn
Summary: Theranostics is a rapidly evolving field of medicine that combines diagnosis and treatment using similar tools. It offers the potential for high therapeutic efficacy with minimal toxicity. In oncology, theranostics relies on the identification of unique proteins and factors expressed in cancer cells, advances in imaging technology, and targeted chemicals and nanodevices for imaging and therapy. Radiotheranostics, using radiopharmaceuticals, is becoming routine in prostate cancer and neuroendocrine tumors. Although not all patients benefit from radiotheranostics, those who do often show high response rates.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. Rockall
Summary: A comprehensive model combining features from MRI and clinical variables can improve the estimation of survival time in women with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Thomas Talbot, Haonan Lu, Eric O. Aboagye
Summary: High-grade serous ovarian carcinoma is characterized by universal TP53 mutations and widespread copy number alterations, including deletion of tumor suppressors and amplification of driver oncogenes. Amplified driver genes have been proposed as therapeutic targets. However, lack of validation and variable experimental procedures hinder clinical translation. This review collates candidate amplified therapeutic targets in high-grade serous ovarian carcinoma and quantitatively appraises the evidence for each gene.
CANCER GENE THERAPY
(2023)
Article
Oncology
Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, Alessio Cortellini, David J. Pinato, Danielle Power, Eric O. Aboagye
Summary: This study developed a radiomic-based signature for predicting disease response in patients with NSCLC undergoing PD-1 or PD-L1 immunotherapy. The radiomic signature was validated in two independent testing cohorts and demonstrated good prediction of treatment response and prognosis.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Xingfeng Li, Michele Dessi, Diana Marcus, James Russell, Eric O. O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. G. Rockall
Summary: Machine learning classification methods can be used to predict deep myometrial infiltration, clinical risk category, histological type, and lymphovascular space invasion in endometrial cancer. Combining clinical and image signatures can improve the accuracy of these prediction models, which has important implications for patient management.
Article
Cell Biology
Haonan Lu, Hantao Lou, Georg Wengert, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye
Summary: This study confirms that the presence of tertiary lymphoid structure (TLS) in high-grade serous ovarian cancer (HGSOC) is associated with better progression-free survival (PFS). TLS is linked to B cell maturation and activation of cytotoxic tumor-specific T cells in HGSOC tumors. Copy-number loss of genes IL15 and CXCL10 may hinder TLS formation in HGSOC, and a list of dysregulated genes affecting TLS function is proposed. A radiomics-based signature is developed to predict TLS presence, which independently predicts PFS in HGSOC and non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Overall, this study reveals the role of TLS in coordinating immune responses in HGSOC and how the cancer genome evolves to counteract TLS formation.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian Mcnamara, Toby Burn, Emily Guilhem, Marcos Mestas Nunez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye, Anand Devaraj
Summary: This study developed a radiomics model to assist in the diagnosis of lung cancer. By extracting radiomics features and using clustering methods, patients were stratified into different risk groups. The model showed high accuracy in predicting malignancy and has potential clinical applications.
BRITISH JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Stanislav S. Piletsky, Ekaterina Baidyuk, Elena V. Piletska, Larissa Lezina, Konstantin Shevchenko, Donald J. L. Jones, Thong H. Cao, Rajinder Singh, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky, Nickolai A. Barlev
Summary: Molecularly imprinted polymer nanoparticles (nanoMIPs) have shown potential as an alternative to antibodies in diagnostic and therapeutic applications. Targeting intracellular epitopes can modulate protein function, making them a new tool for cancer therapy.
Article
Oncology
Mitchell Chen, Susan J. Copley, Patrizia Viola, Haonan Lu, Eric O. Aboagye
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, can be captured non-invasively on medical imaging as radiomic features, which can be used in an artificial intelligence paradigm to predict clinical outcomes and improve patient care. Compared to tissue sampling-driven approaches, radiomics-based methods are superior for being non-invasive, reproducible, cheaper, and less susceptible to intra-tumoral heterogeneity.
SEMINARS IN CANCER BIOLOGY
(2023)
Letter
Medicine, General & Internal
Benjamin Hunter, Catey Bunce, Matthew Blackledge, Eric Aboagye, Richard Lee, LIBRA study
Article
Oncology
Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye, Laura M. Kenny
Summary: This study aimed to investigate the early drug action of the antifolate drug pemetrexed on thymidylate synthase (TS) inhibition using F-18-FLT PET/CT imaging. The results showed that patients who exhibited changes in the imaging biomarker had a better therapy response and longer overall survival. These findings suggest the potential use of F-18-FLT PET/CT in understanding the basis of drug action in studies involving TS inhibitors.
Article
Pharmacology & Pharmacy
Jin Hui Teh, Ala Amgheib, Ruisi Fu, Chris Barnes, Joel Abrahams, Ali Ashek, Ning Wang, Zixuan Yang, Muneera Mansoorudeen, Nicholas J. J. Long, Eric O. O. Aboagye
Summary: C-Met, a receptor tyrosine kinase overexpressed in various cancer types, has potential as a biomarker for cancer imaging and therapy. This study synthesized and evaluated an [F-18]AlF-labelled analogue, [F-18]AlF-EMP-105, for c-Met imaging using positron emission tomography. In vitro evaluation showed high specificity of [F-18]AlF-EMP-105 for c-Met-expressing cells. PET imaging in mice demonstrated renal clearance of the tracer predominantly as [F-18]fluoride. [F-18]AlF-EMP-105 shows promise as a diagnostic tool for imaging cancer due to its high specificity for c-Met expressing cells.
Article
Multidisciplinary Sciences
Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. O. Aboagye, Richard W. W. Lee, Matthew D. D. Blackledge
Summary: Researchers developed a contrast-based CT image synthesis method to address the contrast heterogeneity issue in real-world datasets and evaluated its performance in COVID-19 research. The results showed that while the generated images demonstrated realism in human assessment, caution is advised when using GAN-synthesized images in medical imaging applications.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Zixuan Yang, Chris Barnes, Juozas Domarkas, Joanna Koch-Paszkowski, John Wright, Ala Amgheib, Isaline Renard, Ruisi Fu, Stephen Archibald, Eric O. Aboagye, Louis Allott
Summary: Sulfur-[F-18]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We reported a fully automated radiolabelling procedure using the GE FASTLab(TM) cassette-based platform to synthesize a [F-18]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([F-18](5)), which showed favorable biodistribution and pharmacokinetic profiles correlated with PSMA expression.
REACTION CHEMISTRY & ENGINEERING
(2023)
