Review
Oncology
Paul Windisch, Carole Koechli, Susanne Rogers, Christina Schroder, Robert Forster, Daniel R. Zwahlen, Stephan Bodis
Summary: In recent years, machine learning in radiology of the central nervous system has gained much attention and produced interesting results. However, the research on benign tumors is still at an early stage. Adherence to best practices in machine learning could facilitate comparisons between studies and contribute to the development of models that have potential for clinical practice.
Article
Clinical Neurology
Lu Wang, Shengkai Yang, Yu Wang, Aimin Li, Shiwei Yan, Xie Kang
Summary: The coexistence of meningioma and pituitary adenoma in the same location is very rare, especially after meningioma surgery. This case report provides a theoretical basis and treatment reference for patients with meningioma and pituitary adenoma diagnosed at the same time.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Geovanne Pedro Mauro, Leila Maria Da Roz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study aimed to evaluate whether fractionated radiotherapy (FRT) is more effective than single-dose radiosurgery (SRS) in the treatment of vestibulocochlear schwannomas in patients with type 2 neurofibromatosis (NF2). The results showed that in the NF2 population, FRT may yield worse control rates than SRS. Therefore, it is preferable to avoid fractionated treatment for these patients whenever possible.
WORLD NEUROSURGERY
(2023)
Review
Endocrinology & Metabolism
Stephanie Du Four, Jorn Van Der Veken, Johnny Duerinck, Elle Vermeulen, Corina E. E. Andreescu, Michael Bruneau, Bart Neyns, Van Velthoven, Brigitte Velkeniers
Summary: In this article, we report a case series of five patients with pituitary carcinoma (PC) and highlight the challenges in diagnosis and treatment. PCs are rare intracranial neoplasms that usually develop from aggressive pituitary adenomas. The mean time interval from initial diagnosis to PC diagnosis was 10.7 years. Various treatment approaches, including surgery, radiotherapy, temozolomide, and immunotherapy, were used, with some patients achieving stable disease. The lack of predictive factors for an aggressive clinical course makes management challenging for PCs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
James R. Janopaul-Naylor, Manali Rupji, Jim Zhong, Bree R. Eaton, Naba Ali, Adriana G. Ioachimescu, Nelson M. Oyesiku, Hui-Kuo G. Shu
Summary: Modern LINAC RT is safe and effective for hormonal control and LC in patients with PAs. There was an increase in the proportion of patients requiring pituitary hormone replacement after RT.
WORLD NEUROSURGERY
(2022)
Article
Endocrinology & Metabolism
Xin Lian, Zhuoran Xu, Shuai Sun, Weiping Wang, Huijuan Zhu, Lin Lu, Xiaorong Hou, Fuquan Zhang
Summary: The study aimed to investigate the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) in treating Cushing's Disease (CD). The results showed that IMRT was a highly effective therapy with low side effects for CD patients, with comparable rates of endocrine remission, tumor control, and recurrence to previous reports.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ahmed Gawish, Nurlan Abdulayev, Souhir El-Arayed, Burkard Roellich, Hans-Joachim Ochel, Thomas B. Brunner
Summary: This study retrospectively analyzed 48 patients with intracranial meningiomas treated with radiation surgery, and found that SFRT had better local control effects in the treatment of Grade I meningiomas compared to SRS. This may be due to the reduced risk of brain necrosis in large PTVs with SFRT. Therefore, SFRT is a better choice for typical meningioma PTVs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Darius Kalasauskas, Michael Kosterhon, Naureen Keric, Oliver Korczynski, Andrea Kronfeld, Florian Ringel, Ahmed Othman, Marc A. Brockmann
Summary: Tumor qualities are crucial for operation planning and treatment. Radiomics is a promising method to determine some of these qualities on preoperative images. This article reviews the use of radiomics in various central nervous system tumors and highlights its important role in neuro-oncology.
Article
Endocrinology & Metabolism
Stephan Gaillard, Sosthene Adeniran, Chiara Villa, Anne Jouinot, Marie-Laure Raffin-Sanson, Loic Feuvret, Pierre Verrelle, Fideline Bonnet, Anthony Dohan, Jerome Bertherat, Guillaume Assie, Bertrand Baussart
Summary: The management of giant pituitary tumors is complex and requires a multi-modal approach, with surgery playing a central role. A multidisciplinary expert team can achieve tumor control and improve visual outcomes in the majority of patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Otorhinolaryngology
Owen Conlan, Georgios Kontorinis
Summary: This study evaluated the long-term outcomes of patients with vestibular schwannomas (VS) after stereotactic radiosurgery (SRS) who experience delayed tumor regrowth. Approximately 4% of cases may experience delayed regrowth after SRS, highlighting the importance of close clinical and radiological follow-up. Despite this abnormal behavior, VS ultimately stop growing again, but patients should be aware of the possibility of this uncommon VS behavior following SRS.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
William Gehin, Benoite Lassalle, Julia Salleron, Rene Anxionnat, Didier Peiffert, Vincent Marchesi, Valerie Bernier-Chastagner
Summary: This study aimed to identify dosimetric predictive factors for facial nerve paralysis in patients with vestibular schwannomas treated with Cyberknife hypofractionated stereotactic radiotherapy. The results showed that prescriptions with a maximum dose point exceeding 30 Gy and 33 Gy substantially increased the risk of facial paralysis. Additionally, GTV minimal dose over 22 Gy, GTV mean dose over 29 Gy, PTV mean dose over 27 Gy, and PTV maximal dose of 32 Gy were identified as significant predictive factors for radiation-induced facial nerve dysfunction. Increasing the doses of hypofractionated stereotactic radiotherapy may lead to higher facial nerve toxicity and lower local control rates.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Hirotaka Hasegawa, Kunal Vakharia, Michael J. Link, Scott L. Stafford, Paul D. Brown, Ian F. Parney, Terry C. Burns, Elizabeth S. Yan, Anita Mahajan, Nadia N. Laack, Bruce E. Pollock
Summary: This retrospective analysis of 68 patients with atypical meningiomas (AM) receiving stereotactic radiosurgery (SRS) showed poor progression-free survival (PFS) despite treatment. Prior external beam radiation therapy (EBRT) was associated with worse tumor control, higher tumor-related mortality, and an increased risk of adverse radiation events (AREs). Further research is needed to determine if upfront adjuvant SRS improves tumor control compared to salvage SRS.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Editorial Material
Clinical Neurology
Ao Chen, Rong Xiang, RenHui Zhou
Summary: Pure intrasellar meningioma is a rare tumor that is difficult to diagnose based on clinical presentation and can only be distinguished through histopathologic examination. Misdiagnosis as pituitary adenoma is common and poses challenges in clinical diagnosis. Magnetic resonance imaging can help enhance the diagnosis of pure intrasellar meningioma by showing the boundary between the tumor and pituitary gland.
WORLD NEUROSURGERY
(2022)
Article
Oncology
S. Sumodhee, V. Atallah, R. Kinj, J. Doyen, B. L'Homel, P. Gillon, P. Paquis, F. Almairac, S. Hieronimus, R. Schiappa, J. -l. Sadoul, D. Sumodhee, N. Pontikos, Q. Richier, J. -m. Hannoun-Levi, C. Scouarnec, N. Chevalier, P. -Y. Bondiau
Summary: This study evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for pituitary adenoma (PA) and found that delivering 35 Gy in 5 fractions is a feasible treatment option that can reduce hormonal overproduction and improve local control.
CANCER RADIOTHERAPIE
(2022)
Article
Endocrinology & Metabolism
Keyi Zhang, Xuefei Shou, Hong Chen, Nidan Qiao, Wenqiang He, Zhengyuan Chen, Ming Shen, Shiqi Li, Yao Zhao, Zhaoyun Zhang, Yiming Li, Hongying Ye, Yongfei Wang
Summary: The study investigated the clinical characteristics of SCAs with positive and negative ACTH immunostaining, finding that ACTH-negative SCAs were more clinically silent and more likely to demonstrate multiple microcysts on MRI. The prevalence of SCAs, especially ACTH-negative SCAs, was substantially underestimated and should be given enough attention due to the high aggressiveness of this subtype of refractory pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
M. -N. Nguyen, G. Noel, D. Antoni
CANCER RADIOTHERAPIE
(2019)
Review
Oncology
Yvan Pin, Adrien Paix, Julien Todeschi, Delphine Antoni, Francois Proust, Georges Noel
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Waisse Waissi, Jean-Christophe Ame, Carole Mura, Georges Noel, Helene Burckel
Summary: The combination of olaparib with gemcitabine-based chemoradiotherapy can significantly enhance radiosensitization in PDAC cell lines, leading to increased cell death and a more pronounced effect at high radiation doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Guillaume Virbel, Clara Le Fevre, Georges Noel, Delphine Antoni
Summary: Stereotactic body radiation therapy (SBRT) is an effective and safe treatment for lung metastases, particularly in oligometastatic patients with localized disease involving one to three organs. This review summarized the recent progress and evaluation results of radiotherapy for pulmonary metastasis in the past five years.
Article
Oncology
J. Eber, B. Leroy-Freschini, D. Antoni, G. Noel, C. Pflumio
Summary: Radiation-induced heart disease is a complication that typically occurs years after thoracic irradiation. However, recent studies suggest that it can also be an earlier complication with subclinical cardiac injury. A case study described a patient who had abnormal cardiac metabolism detected incidentally after breast irradiation, but remained asymptomatic with normal angiography, indicating radiation-induced hibernating myocardium.
CANCER RADIOTHERAPIE
(2022)
Article
Oncology
Martin Schmitt, Isabelle Chambrelant, Parigna Hong Chheang, Carole Pflumio, Carole Hild, Thierry Petit, Georges Noel
Summary: This retrospective study evaluated the incidental axillary dose delivered during whole breast irradiation using different techniques, as well as the risk factors for axillary recurrence in breast cancer patients. The results showed that the irradiation technique affected the incidental dose delivered to the axillary area, but had no impact on the risk of axillary recurrence. The risk of lymphedema was found to be associated with the use of high tangential beams and the mean dose delivered at level II.
Article
Oncology
Martin Schmitt, Lucie Aussenac, Joseph Seitlinger, Veronique Lindner, Georges Noel, Delphine Antoni
Summary: Stereotactic radiotherapy is a viable alternative for patients with localised stage non-small-cell lung carcinoma who are inoperable or refuse surgery. The microscopic tumour extension varies according to histological type, with different adapted margins needed for squamous cell carcinoma and adenocarcinoma. Multivariate analysis showed a significant relationship between maximum microextension distance, size, and shrinkage coefficient.
Review
Oncology
Monica Ribeiro, Mohamed Amine Benadjaoud, Laura Moisy, Julian Jacob, Loic Feuvret, Alexander Balcerac, Marie-Odile Bernier, Dimitri Psimaras, Khe Hoang-Xuan, Georges Noel, Nathalie Jouniaux-Delbez, Damien Ricard
Summary: High-grade glioma patients are at high risk of developing depression and anxiety symptoms at different stages of the disease. Early palliative care and personalized psychosocial interventions are essential for improving patients' quality of life.
Review
Oncology
Benoit Lhermitte, Thibaut Wolf, Marie Pierre Chenard, Andres Coca, Julien Todeschi, Francois Proust, Edouard Hirsch, Roland Schott, Georges Noel, Eric Guerin, Damien Reita, Agathe Chammas, Alexandra Salmon, Sophie Martin, Monique Dontenwill, Natacha Entz-Werle
Summary: Drugs targeting activating BRAF mutations have transformed the prognosis and treatment of MAPK-pathway-induced cancers. The better knowledge of the MAPK pathway's involvement in gliomagenesis offers hope in brain cancers where conventional therapies have produced disappointing results. This review summarizes the current literature regarding BRAF-altered gliomas, their molecular diagnosis, prognosis, associated molecular alterations, and potential treatment options.
Article
Oncology
Lucas Geyer, Thibaut Wolf, Marie-Pierre Chenard, Helene Cebula, Roland Schott, Georges Noel, Eric Guerin, Erwan Pencreach, Damien Reita, Natacha Entz-Werle, Benoit Lhermitte
Summary: The 2021 WHO classification of central nervous system tumors is a histomolecular classification system that incorporates molecular data to improve patient prognoses and treatments. CDKN2A homozygous deletion is associated with poor prognosis in various types of gliomas, and its detection requires complex techniques. This study investigates the clinical significance of p16 immunohistochemical expression in gliomas and its correlation with CDKN2A homozygous deletion.
Article
Oncology
Jordan Eber, Cyrille Blondet, Martin Schmitt, David G. Cox, Claire Vit, Clara Le Fevre, Delphine Antoni, Fabrice Hubele, Georges Noel
Summary: Breast radiotherapy can cause radiation-induced cardiac disease, especially in left breast cancers. A prospective single-center study will be conducted to explore alternative approaches, such as deep inspiration breath hold radiotherapy and intensity modulated radiation therapy, to reduce the risk of myocardial perfusion defects in patients with left breast cancer. The study will use stress and resting myocardial scintigraphy to assess myocardial perfusion and aims to demonstrate the effectiveness of reducing cardiac dose in preventing early and medium-term perfusion disorders.
Review
Oncology
Arthur Lebas, Clara Le Fevre, Waisse Waissi, Isabelle Chambrelant, David Brinkert, Georges Noel
Summary: This article provides a systematic review of studies on soft tissue sarcomas of the extremities treated with radiotherapy. The analysis reveals the great heterogeneity among these studies and the difficulty in identifying significant prognostic factors for the benefit of radiotherapy. The review provides valuable insights for optimizing radiotherapy treatment for patients with soft tissue sarcomas of the extremities.
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Review
Oncology
Isabelle Chambrelant, Delphine Jarnet, Jolie Bou-Gharios, Clara Le Fevre, Laure Kuntz, Delphine Antoni, Catherine Jenny, Georges Noel
Summary: Solid tumors often cause brain metastases (BMs), and stereotactic radiotherapy (SRT) plays a major role in their treatment. This systematic review summarizes the dosimetric studies of SRT for single BMs and highlights the challenges in comparing different studies due to variations in factors such as PTV margins and volumes, total dose, number of fractions, and isodose prescription. Optimal dosimetric parameters, such as conformity and gradient indexes, need to be considered to minimize radiation exposure to healthy tissue. Future well-designed studies are needed to establish guidelines for selecting the most suitable SRT technique based on the characteristics of treated BMs.
Article
Biochemistry & Molecular Biology
Anasse Nounsi, Joseph Seitlinger, Charlotte Ponte, Julien Demiselle, Ysia Idoux-Gillet, Erwan Pencreach, Michele Beau-Faller, Veronique Lindner, Jean-Marc Balloul, Eric Quemeneur, Helene Burckel, Georges Noel, Anne Olland, Florence Fioretti, Pierre-Emmanuel Falcoz, Nadia Benkirane-Jessel, Guoqiang Hua
Summary: Radiation therapy and platinum-based chemotherapy are common treatments for lung cancer patients. Factors such as the patient's physical state and tumor heterogeneity contribute to the low overall survival rate in lung cancer. This study demonstrates that a patient-derived tumoroid model can be used to predict the efficacy of radiation therapy and cisplatin-based chemotherapy in non-small-cell lung cancer, and the results are correlated to clinical outcomes.
